Protein detail

TGM2

Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)

Entry name TGM2	UniProt ID P21980	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Protein Class (6)

Disease related genesEnzymesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted secreted proteins

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases
Disease related genes

Ensembl

ENSG00000198959

Entrez Gene Symbol

TGM2

Gene Synonym

TGC

Gene Description

Transglutaminase 2

Chromosome

Position

38127385-38166578

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway6

Protein Function (7)

Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Predicted secreted proteins
ENZYME proteins:Hydrolases
Disease related genes

Cellular Component (12)

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Molecular Function (10)

Biological Process (3)

KEGG

hsa05016 Huntington disease

Mediation Categories (5)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence35

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TGM2	PRKACA	P17612	S	215	phosphorylation	PhosphoSite_MIMPMIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
TGM2	PRKACA	P17612	S	216	phosphorylation	PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
TGM2	PRKDC	P78527	T	162	phosphorylation	PhosphoSite
TGM2	SRC	P12931	Y	369	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (24)

24 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	OmniPath	No	No	Yes	No	No
ecm_regulator	ecm_regulator	Matrisome	Yes	No	Yes	No	No
ecm_regulator	ecm_regulator	OmniPath	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	Yes	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	Yes	No	No
secreted	secreted	UniProt_keyword	No	No	Yes	No	No
secreted	secreted	UniProt_location	No	No	Yes	No	No
secreted	secreted	connectomeDB2020	No	No	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KAPCA	P17612	TGM2	P21980	Yes	No	No	PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:22142843 PhosphoSite:16870138

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
FN1-TGM2 complex	FN1 TGM2	P02751 P21980	1:1	CompleatCORUM	CORUM:2375Compleat:HC837	10684262
TGM2-HD complex	HTT TGM2	P21980 P42858	1:1	CompleatCORUM	CORUM:2243Compleat:HC1631	11442349
TGM2-HD-CALM1 complex	CALM3 HTT TGM2	P0DP25 P21980 P42858	1:1:1	Compleat	Compleat:HC2694	14985437
TGM2-HD-CALM1 complex	CALM1 HTT TGM2	P21980 P42858 P62158	0:0:0	CORUM	CORUM:2242	14985437
	TGM2	P21980	6	PDB	PDB:6a8pPDB:4pygPDB:6kzbPDB:3ly6PDB:9bc3PDB:1kv3

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	1	37886648

Sequence, Structure & Domains11

Sequences

Length

687

Mass

77,329

Sequence

MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P21980-1; Sequence=Displayed; Name=2; Synonyms=TGase-S; IsoId=P21980-2; Sequence=VSP_006411, VSP_006412; Name=3; Synonyms=TGH2; IsoId=P21980-3; Sequence=VSP_006413, VSP_006414

Alternative Sequence

287..349; VLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQP -> GELHAGMWVMSPGRGHEEHWSRNQDIPALVLPPATNTLNALCGLEPVTTLSGPLSNSHPSSGC (in isoform 3); 350..687; Missing (in isoform 3); 539..548; EKSVPLCILY -> GKALCSWSIC (in isoform 2); 549..687; Missing (in isoform 2)

3D Structural Models

Turn

52..54; 69..72; 227..229; 231..234; 251..253; 267..269; 387..389; 462..465; 468..471; 552..554; 570..573; 627..629

Helix

14..20; 24..26; 153..159; 189..198; 201..205; 207..213; 217..226; 245..247; 258..266; 277..291; 311..317; 376..380; 390..397; 440..443; 450..460; 548..551

Beta Strand

7..11; 28..30; 32..34; 39..48; 55..66; 73..79; 85..87; 89..95; 97..105; 113..123; 126..138; 164..170; 172..181; 235..239; 255..257; 272..275; 295..304; 306..309; 332..342; 347..350; 353..357; 365..369; 400..404; 412..414; 419..429; 433..438; 447..449; 473..478; 489..497; 499..501; 503..514; 520..534; 538..546; 560..569; 574..583; 590..595; 598..601; 603..610; 613..615; 619..625; 634..638; 647..654; 658..660; 662..669; 671..673; 676..682

3D Structure

Electron microscopy (1); X-ray crystallography (12)

Domain & Motif Annotations

Protein Families (2)

Transglutaminase superfamily
Transglutaminase family

Sequence Similarities

Belongs to the transglutaminase superfamily. Transglutaminase family.

Clinical Relevance5

Antibody (3)

CAB002598 HPA021019 HPA029518

Interaction Protein (2)

ENSG00000115414ENSG00000173039

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
22624035	Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.	In addition, the elevation of exosome secretion by RHBDD1 inactivation was reduced when TSAP6 was knocked down, indicating that the role of RHBDD1 in regulating exosomal trafficking is very likely to be TSAP6-dependent. The increased exosome secretion was verfied through the detection of certain exosomal components, including Tsg101, Tf-R, FasL and Trail. We found that the increase in FasL and Trail increased exosome-induced apoptosis in Jurkat cells.