Protein detail
TGM1
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]
Entry name TGM1 | UniProt ID | EVMP confidence score 0.72 |
Supporting publications (n) 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
ICR2LILI1TGASETGK
Gene Description
Transglutaminase 1
Chromosome
14
Position
24249114-24264432
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization2
Cell SpecificAstrocytes
Function & Pathway7
Protein Function (6)
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
Mediation Categories
Clinical-translation mediation
Relations & Evidence11
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | No | No | No |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | No | No | No |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | 1 | 31414377 |
Sequence, Structure & Domains13
Sequences
Length
817
Mass
89,787
Sequence
MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22735-1; Sequence=Displayed; Name=2; IsoId=P22735-2; Sequence=VSP_056840
Alternative Sequence
1..442; Missing (in isoform 2)
3D Structural Models
Turn
731..733
Helix
773..776
Beta Strand
693..699; 703..705; 707..714; 717..719; 723..730; 734..741; 749..756; 767..771
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
17..26; Pro residues; 71..84; Low complexity
Region
1..100; Membrane anchorage region; 1..38; Disordered; 59..105; Disordered; 793..817; Disordered
Protein Families (2)
- Transglutaminase superfamily
- Transglutaminase family
Sequence Similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Clinical Relevance4
Disease Involvement (2)
Disease variantIchthyosis
Related Diseases
Biomarker
Phase 2
Supporting Publications16
| PMID | Title | Abstract |
|---|---|---|
| 31617158 | Proteomic profiling of peritoneal dialysis effluent-derived extracellular vesicles: a longitudinal study. | No abstract available |
| 32106990 | Characterization of exosomes in peritoneal fluid of endometriosis patients. | No abstract available |
| 32230970 | Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles. | No abstract available |
| 32560723 | T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles. | No abstract available |
| 36982312 | Saliva and Saliva Extracellular Vesicles for Biomarker Candidate Identification-Assay Development and Pilot Study in Amyotrophic Lateral Sclerosis. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 37563857 | Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications. | No abstract available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 38891077 | Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. | No abstract available |
Page 1 of 2Next