Protein detail
TGM1
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]
Protein symbol TGM1 | UniProt ID | EVMP score 0.72 |
Frequency 16 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins |
Basic Information
Protein Names
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
ICR2LILI1TGASETGK
Gene Description
Transglutaminase 1
Chromosome
14
Position
24249114-24264432
Frequency
16
EVMP Score
0.72
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Human disease related genes:Congenital malformations:Congenital malformations of skin
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ecm_regulator | ecm_regulator | Matrisome | Yes | No | No | No | No |
| ecm_regulator | ecm_regulator | OmniPath | Yes | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
817
Mass
89,787
Sequence
MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22735-1; Sequence=Displayed; Name=2; IsoId=P22735-2; Sequence=VSP_056840
Alternative Sequence
1..442; Missing (in isoform 2)
3D Structural Models
Turn
731..733
Helix
773..776
Beta Strand
693..699; 703..705; 707..714; 717..719; 723..730; 734..741; 749..756; 767..771
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
17..26; Pro residues; 71..84; Low complexity
Region
1..100; Membrane anchorage region; 1..38; Disordered; 59..105; Disordered; 793..817; Disordered
Protein Families
- Transglutaminase superfamily
- Transglutaminase family
Sequence Similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Clinical Relevance
Disease Involvement
Disease variantIchthyosis
Related Diseases
Biomarker
Phase 2