Protein detail

TGM1

Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]

Entry name
TGM1
UniProt ID
P22735
EVMP confidence score
0.72
Supporting publications (n)
16
Transmembrane count
Protein classification
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Protein-glutamine gamma-glutamyltransferase K (EC 2.3.2.13) (Epidermal TGase) (Transglutaminase K) (TG(K)) (TGK) (TGase K) (Transglutaminase-1) (TGase-1) [Cleaved into: Protein-glutamine gamma-glutamyltransferase K 67 kDa chain; Protein-glutamine gamma-glutamyltransferase K 33 kDa chain]
Protein Class (7)
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Disease related genes
Ensembl
ENSG00000092295
Entrez Gene Symbol
TGM1
Gene Synonym (5)
ICR2LILI1TGASETGK
Gene Description
Transglutaminase 1
Chromosome
14
Position
24249114-24264432
Supporting publications (n)
16
EVMP confidence score
0.72
Fluorescence & Localization2
TGM1 fluorescence
Cell SpecificAstrocytes
Function & Pathway7
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • Potential drug targets
  • Enzymes
  • Human disease related genes:Congenital malformations:Congenital malformations of skin
  • Disease related genes
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
KEGG
hsa04382 Cornified envelope formation
Reactome (2)
Mediation Categories
Clinical-translation mediation
Relations & Evidence11

Ligand-Receptor Signaling (8)

8 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularLOCATENoNoNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
ecm_regulatorecm_regulatorMatrisomeYesNoNoNoNo
ecm_regulatorecm_regulatorOmniPathYesNoNoNoNo

Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ALOX12BKPRPNCCRP1TGM1O75342P22735Q5T749Q6ZVX70:0:0:0hu.MAP
KPRPTGM1P22735Q5T7490:0hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion Chromatography131414377
Sequence, Structure & Domains13

Sequences

Length
817
Mass
89,787
Sequence
MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P22735-1; Sequence=Displayed; Name=2; IsoId=P22735-2; Sequence=VSP_056840
Alternative Sequence
1..442; Missing (in isoform 2)

3D Structural Models

Turn
731..733
Helix
773..776
Beta Strand
693..699; 703..705; 707..714; 717..719; 723..730; 734..741; 749..756; 767..771
3D Structure
X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias
17..26; Pro residues; 71..84; Low complexity
Region
1..100; Membrane anchorage region; 1..38; Disordered; 59..105; Disordered; 793..817; Disordered
Protein Families (2)
  • Transglutaminase superfamily
  • Transglutaminase family
Sequence Similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Clinical Relevance4
Disease Involvement (2)
Disease variantIchthyosis
Related Diseases
Autosomal Recessive Ichthyosis
Biomarker
Phase 2
Antibody (3)
CAB015159HPA040171HPA070372
Supporting Publications16
PMIDTitleAbstract
38895962A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis.No abstract available
39001700Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.No abstract available
39207047The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.No abstract available
40840701Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.No abstract available
40985879TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins.No abstract available
41068253Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression.No abstract available
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