Protein detail

EDNRB

Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)

Entry name EDNRB	UniProt ID P24530	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 7	Protein classification Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)

Protein Class (5)

Disease related genesFDA approved drug targetsG-protein coupled receptorsHuman disease related genesPredicted membrane proteins

Protein Function (7)

Human disease related genes:Cancers:Head and neck cancers
Human disease related genes:Other diseases:Others
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

102..126; Helical; Name=1; 138..163; Helical; Name=2; 176..197; Helical; Name=3; 219..243; Helical; Name=4; 272..296; Helical; Name=5; 325..350; Helical; Name=6; 363..389; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000136160

Entrez Gene Symbol

EDNRB

Gene Synonym (3)

ETBHSCRHSCR2

Gene Description

Endothelin receptor type B

Chromosome

Position

77895481-77975529

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Secretome LocationIntracellular and membraneSecretome FunctionTransport

Function & Pathway8

Protein Function (7)

Human disease related genes:Cancers:Head and neck cancers
Human disease related genes:Other diseases:Others
Human disease related genes:Congenital disorders of metabolism:Other congenital disorders of metabolism
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
G-protein coupled receptors:GPCRs excl olfactory receptors
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (2)

Molecular Function (4)

Biological Process (3)

KEGG (6)

Reactome (7)

Canonical Pathways (3)

M3468 Naba ecm regulators
M5885 Naba matrisome associated
M5889 Naba matrisome

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence80

Ligand-Receptor Signaling (64)

64 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Kirouac2010	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (13)

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EDN3	P14138	EDNRB	P24530	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	connectomeDB2020:8460684 Cellinker:8001160 scConnect:7524189 LRdb:7524189 LRdb:11982704 LRdb:8460684 LRdb:8086489 connectomeDB2020:11982704 connectomeDB2020:8086489 HINT:7509919 LRdb:8001160 Baccin2019:8460684 ICELLNET:15629009 Baccin2019:8001160 connectomeDB2020:8001160 SIGNOR:8086489 Cellinker:7524189 Baccin2019:7524189 Cellinker:8904635 HINT:30413709 Guide2Pharma:7524189 ICELLNET:8440682 Cellinker:8460684 LRdb:8904635 Guide2Pharma:8904635 HPMR:8001160 scConnect:8904635 Baccin2019:8086489 connectomeDB2020:8904635 CellTalkDB:11982704 HPRD:8001160 HPRD:11982704 Baccin2019:11982704 Guide2Pharma:8460684 Cellinker:11982704 connectomeDB2020:7524189 Baccin2019:8904635 scConnect:8460684 Cellinker:8086489
EDNRB	P24530	GNAI1	P63096	Yes	Yes	No	WangHINTSIGNOR	HINT:36882417 HINT:37096326 SIGNOR:31160049
EDNRB	P24530	GNAQ	P50148	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
EDNRB	P24530	GNAO	P09471	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
EDNRB	P24530	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
EDNRB	P24530	GNAI3	P08754	Yes	Yes	No	WangSIGNOR	SIGNOR:31160049
EDN1	P05305	EDNRB	P24530	Yes	Yes	No	iTALKICELLNETSIGNORHINTCellChatDBHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015CellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb	CellTalkDB:12972292 ICELLNET:15629009 HINT:36882417 HINT:37096326 ICELLNET:8440682 HPRD:12972292 HINT:23597562 connectomeDB2020:12972292 Cellinker:12972292 LRdb:12972292 SIGNOR:16597412 SPIKE_LC:16713569 Baccin2019:12972292
EDNRB	P24530	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049
EDNRB	P24530	GNAS2	P63092	Yes	Yes	No	SIGNOR	SIGNOR:31160049
EDNRB	P24530	GNAS1	Q5JWF2	Yes	Yes	No	SIGNOR	SIGNOR:31160049

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	EDN1 EDNRB	P05305 P24530	1:1	PDB	PDB:8iy6PDB:8zrtPDB:5glh
	EDN3 EDNRB	P14138 P24530	1:1	PDB	PDB:6igk

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains12

Sequences

Length

442

Mass

49,644

Sequence

MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=P24530-1; Sequence=Displayed; Name=B; IsoId=P24530-2; Sequence=VSP_001879; Name=C; Synonyms=Delta-3; IsoId=P24530-3; Sequence=VSP_001878

Alternative Sequence

1; M -> MNKSTCLMAAETPSKRWRLHCLAFSQRFVRAGPACSSREACSSPRAGWNPAGFRLPGRWSPFVALHLVCQIREALKLRSGHRTPSGAGSSM (in isoform C); 399..442; SCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS -> AGPHVGNKLVMLFSVNIECDGTVNQNPTMWPERKSNNN (in isoform B)

3D Structural Models

Turn

355..357

Helix

98..128; 130..132; 135..164; 170..204; 216..232; 234..239; 264..281; 283..310; 313..349; 358..389; 391..401

Beta Strand

206..208; 212..214; 240..247; 250..257; 352..354

3D Structure

Electron microscopy (10); X-ray crystallography (7)

Domain & Motif Annotations

Region

69..88; Disordered

Protein Families (3)

G-protein coupled receptor 1 family
Endothelin receptor subfamily
EDNRB sub-subfamily

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.

Clinical Relevance6

Disease Involvement (6)

AlbinismDeafnessDisease variantFDA approved drug targetsHirschsprung diseaseWaardenburg syndrome

Related Diseases (10)

Cardiac arrhythmia Cardiovascular disease Encephalopathy Hypertension Kidney failure Melanoma Myasthenia gravis Neuromyelitis optica Pulmonary hypertension Solid tumour/cancer

Biomarker

Discontinued in Phase 2; Approved; Phase 3; Phase 2; Phase 1/2

Drug Targets

FDA approved drug targets

Drugs (15)

BOSENTAN ANHYDROUS AMBRISENTAN PACLITAXEL SOVATELTIDE DARUSENTAN ENDOTHELIN-1 BQ788 SITAXENTAN SODIUM ENRASENTAN MACITENTAN SITAXENTAN RG-7636 APROCITENTAN TEZOSENTAN NULL

Antibody (2)

CAB017842 HPA027546

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40928027	Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes.	No abstract available