Protein detail
PAR1
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Protein symbol PAR1 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Proteinase-activated receptor 1 (PAR-1) (Coagulation factor II receptor) (Thrombin receptor)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
103..128; Helical; Name=1; 138..157; Helical; Name=2; 177..198; Helical; Name=3; 219..239; Helical; Name=4; 269..288; Helical; Name=5; 312..334; Helical; Name=6; 351..374; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CF2RPAR-1PAR1TR
Gene Description
Coagulation factor II thrombin receptor
Chromosome
5
Position
76716126-76735770
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04020 Calcium signaling pathway
- KEGG:hsa04024 cAMP signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04610 Complement and coagulation cascades
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa05130 Pathogenic Escherichia coli infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-140875 common pathway of fibrin clot formation
- R-hsa-140877 formation of fibrin clot clotting cascade
- R-hsa-500792 gpcr ligand binding
- R-hsa-416476 g alpha q signalling events
- R-hsa-109582 hemostasis
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-372790 signaling by gpcr
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
27 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| F2R | F2 | P00734 | F | 43 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | F2 | P00734 | R | 25 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | F2 | P00734 | R | 41 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | A | 36 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | A | 86 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | ELANE | P08246 | V | 72 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | P | 48 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | A | 36 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | A | 92 | cleavage | SIGNOR | SIGNOR:10978167 |
| F2R | PRTN3 | P24158 | V | 72 | cleavage | SIGNOR | SIGNOR:10978167 |
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Ligand-Receptor Signaling
63 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| receptor | receptor | LRdb | No | Yes | No | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | No | Yes | No |
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Regulatory Interaction Network
17 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PAR1 | P25116 | GNA15 | P30679 | Yes | Yes | No | WangHPRDSPIKE_LCSIGNOR | HPRD:10644723SPIKE_LC:16189514SIGNOR:31160049 |
| PAR1 | P25116 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNAQ | P50148 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| PAR1 | P25116 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| ELNE | P08246 | PAR1 | P25116 | Yes | Yes | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
| CAN1 | P07384 | PAR1 | P25116 | Yes | Yes | Yes | HPRDSIGNOR | SIGNOR:10978167HPRD:10978167 |
Page 2 of 2Previous
Protein Complex Composition
23 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| F2F2RL3 | P00734Q96RI0 | 4:2 | PDB | PDB:3qdz | ||
| IGF2IGF2R | P01344P11717 | 2:2 | PDB | PDB:2l29PDB:2v5p | ||
| CSF2CSF2RA | P04141P15509 | 1:1 | PDB | PDB:4rs1 | ||
| CSF2RBIL5IL5RA | P05113P32927Q01344 | 2:2:1 | PDB | PDB:8tld | ||
| IGF2R | P11717 | 2 | PDB | PDB:6z32PDB:1gqbPDB:6z31PDB:1e6f | ||
| IGF2RSNX1SNX5 | P11717Q13596Q9Y5X3 | 1:1:1 | PDB | PDB:8afz | ||
| IGF2RSUGP2TIMM10BTMEM126B | P11717Q8IUX1Q8IX01Q9Y5J6 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_335 | ||
| IGF2RSERINC1TIMM10BTM9SF4TMX2 | P11717Q92544Q9NRX5Q9Y320Q9Y5J6 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_464 | ||
| GGA3IGF2R | P11717Q9NZ52 | 4:4 | PDB | PDB:1jplPDB:1lf8 | ||
| GGA1IGF2R | P11717Q9UJY5 | 2:2 | PDB | PDB:1jwg |
Sequence, Structure & Domains
Sequences
Length
425
Mass
47,441
Sequence
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
3D Structural Models
Turn
47..50; 247..250; 339..341
Helix
92..96; 99..102; 104..130; 131..133; 136..152; 155..163; 172..205; 207..213; 216..238; 260..264; 265..296; 305..324; 327..338; 347..360; 363..373; 376..379
Beta Strand
39..41; 43..46; 243..246; 251..257
3D Structure
Electron microscopy (3); X-ray crystallography (10)
Domain & Motif Annotations
Domain (CC)
The cleaved signal peptide may not be degraded and may function as an intracellular angiogenesis inhibitor peptide known as parstatin.
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Investigative; Terminated; Phase 2; Approved
Drug Targets
FDA approved drug targets
Drugs
N-(5-{4-CHLORO-3-[(2-HYDROXYETHYL)SULFAMOYL]PHENYL}-4-METHYL-1,3-THIAZOL-2-YL)ACETAMIDEDEHYDRATED ALCOHOLASPIRINATROPINEVORAPAXARBEVACIZUMAB-AWWBVORAPAXAR SULFATEPZ-128TORIN 2CLOPIDOGRELNULLTYROSINE KINASE INHIBITORRECOMBINANT TRANSFORMING GROWTH FACTORWORTMANNINTHERAPEUTIC GLUCOCORTICOIDTHROMBINALPROSTADILCOMPOUND 22 [WO2019141694A1]BLEOMYCINPAREGORICTINZAPARIN SODIUMATOPAXARTHALIDOMIDEDESIRUDINARGATROBANRUSALATIDE