Protein detail
MYP0
Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero)
Protein symbol MYP0 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Myelin protein P0 (Myelin peripheral protein) (MPP) (Myelin protein zero)
Protein Class
Disease related genesHuman disease related genesPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Transmembrane
154..179; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CMT1CMT1BCMT2ICMT2JHMSNIBP0
Gene Description
Myelin protein zero
Chromosome
1
Position
161304735-161309968
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificNeutrophilsSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MPZ | PRKCB | P05771 | S | 210 | phosphorylation | KEA | KEA:17570479 |
| MPZ | PRKCB | P05771 | S | 228 | phosphorylation | KEA | KEA:17570479 |
| MPZ | PRKCB | P05771 | S | 233 | phosphorylation | KEA | KEA:17570479 |
| MPZ | PRKCB | P05771 | S | 243 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PMP22 | Q01453 | MYP0 | P25189 | Yes | Yes | No | HPRDSPIKE_LCSIGNOR | SIGNOR:10212299SPIKE_LC:16189514HPRD:10212299 |
Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ALDH1A2ALDH2IFIH1LGMNMPZL1RMDN1 | O94788O95297P05091Q96DB5Q99538Q9BYX4 | 0:0:0:0:0:0 | hu.MAP2 | |||
| ALDH1A2IFIH1MPZL1 | O94788O95297Q9BYX4 | 0:0:0 | hu.MAP2 | |||
| MPZL1 | O95297 | 6 | PDB | PDB:6igoPDB:6igt | ||
| MPZL1PTPN11 | O95297Q06124 | 1:1 | PDB | PDB:9mq5 | ||
| MPZ | P25189 | 2 | PDB | PDB:3oai | ||
| GCNT2MPZL3TMEM79 | Q6UWV2Q8N0V5Q9BSE2 | 0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
248
Mass
27,555
Sequence
MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVSEKKAKGLGESRKDKK
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P25189-1; Sequence=Displayed; Name=L-MPZ; IsoId=P25189-2; Sequence=VSP_045844
Alternative Sequence
248; K -> KRLAGRAGDRGLGVESAKGPKVMVIEMELRKDEQSPELRPAVKSPSRTSLKNALKNMMGLNSDK (in isoform L-MPZ)
3D Structural Models
Turn
94..97
Helix
105..107; 119..121
Beta Strand
31..34; 36..41; 46..48; 50..53; 63..70; 77..83; 86..89; 91..93; 99..101; 112..114; 123..130; 138..148
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
30..143; Ig-like V-type
Region
224..248; Disordered
Protein Families
Myelin P0 protein family
Sequence Similarities
Belongs to the myelin P0 protein family.
Clinical Relevance
Disease Involvement
Charcot-Marie-Tooth diseaseDeafnessDejerine-Sottas syndromeDisease variantNeurodegenerationNeuropathy
Antibody