EV MemProt Atlas

Basic Information10

Protein Names

Moesin (Membrane-organizing extension spike protein)

Protein Class (5)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000147065

Entrez Gene Symbol

MSN

Gene Description

Moesin

Chromosome

X

Position

65588377-65741931

Supporting publications (n)

2

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificBergmann glia

Function & Pathway8

Protein Function (4)

Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Mutational cancer driver genes
Disease related genes
Predicted intracellular proteins

Cellular Component (22)

Page 1 of 3

Molecular Function (8)

Biological Process (3)

KEGG (6)

Reactome (13)

Page 1 of 2

Canonical Pathways (2)

M161 Pid ifng pathway
M100 Pid shp2 pathway

Mediation Categories (4)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence62

Enzyme-Mediated Modification (27)

27 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
MSN	RENBP	P51606	T	558	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:26956714 ProtMapper:22251897 ProtMapper:26381822
MSN	NGF	P01138	T	558	phosphorylation	REACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:20307615
MSN	F2	P00734	T	558	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:9456324
MSN	TNF	P01375	T	558	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:26381822
MSN	HMGB1	P09429	T	558	phosphorylation	REACH_ProtMapperProtMapper	ProtMapper:25947626
MSN	ESR1	P03372	T	558	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:24904530
MSN	OXA1L	Q15070	T	558	phosphorylation	Sparser_ProtMapperProtMapper	ProtMapper:22251897

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Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Ramilowski_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Page 2 of 3Previous Next

Regulatory Interaction Network (7)

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
LRRK2	Q5S007	MOES	P26038	Yes	Yes	No	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHINTKEAphosphoELM_KEAIntActphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:19570025 IntAct:27357661 HINT:26824392 IntAct:22952686 ProtMapper:19027715 HINT:24695735 KEA:9856983 IntAct:26824392 HINT:22363216 IntAct:23241358 ProtMapper:17447891 ProtMapper:18973807 ProtMapper:20949042 KEA:15634677 HINT:25009464 ProtMapper:21603132 IntAct:25009464 HINT:23241358 HINT:27357661 ProtMapper:19740074 ProtMapper:19152505 HINT:20642453 IntAct:24695735 SIGNOR:17447891 SIGNOR:8537411 HINT:24904275 phosphoELM:17447891 KEA:9516463 HINT:22952686 IntAct:20642453 ProtMapper:20696313 ProtMapper:8537411 IntAct:24904275 HINT:24351927 IntAct:24351927 KEA:17447891 ProtMapper:19890007
RHOA	P61586	MOES	P26038	Yes	Yes	No	AdhesomeiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapper	ProtMapper:9856983 ProtMapper:35267019 ProtMapper:11867620 ProtMapper:10631797 SIGNOR:35267019 Adhesome:15659383
ROCK1	Q13464	MOES	P26038	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperAdhesomeACSN	SIGNOR:9856983 HPRD:9516463 ACSN:10047517 Adhesome:9516463 Adhesome:9856983 KEA:9856983 ProtMapper:9516463 ACSN:8522586 ACSN:8527459 ACSN:12045227 ACSN:7579708 HINT:9516463 KEA:15634677 iPTMnet:9516463 HINT:9856983 ACSN:9287351 ProtMapper:9856983 ACSN:10970850 ACSN:12802084 KEA:9516463 HPRD:9856983 ACSN:12778124
KPCT	Q04759	MOES	P26038	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSite	PhosphoSite:21666723 SIGNOR:9856983 HPRD:9516463 PhosphoSite:15634677 KEA:9856983 ProtMapper:9516463 PhosphoSite:34603794 KEA:15634677 PhosphoSite:21725352 iPTMnet:9516463 PhosphoSite:10480873 KEA:17447891 ProtMapper:9856983 ProtMapper:21546114 PhosphoSite:9516463 KEA:9516463 HPRD:9856983 PhosphoSite:19027715 PhosphoSite:16601072
STK10	O94804	MOES	P26038	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperELMdbPTMphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	dbPTM:19255442 phosphoELM:19255442 ELM:19255442 ProtMapper:19255442 SIGNOR:19255442
MRCKB	Q9Y5S2	MOES	P26038	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:10947843 ProtMapper:10947843
GRK5	P34947	MOES	P26038	Yes	No	No	Sparser_ProtMapperiPTMnetProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:24755472 ProtMapper:26226012 ProtMapper:24755472

Protein Complex Composition (5)

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
MSN/PDZD8	MSN PDZD8	P26038 Q8NEN9	0:0	SIGNOR	SIGNOR:SIGNOR-C61
	ETFA HADHA HADHB MSN	P13804 P26038 P40939 P55084	0:0:0:0	Havugimana2012	Havugimana2012:C_283
	CCT2 CCT3 CCT4 CCT6A CCT7 DSP IGBP1 MSN PPP2CA PPP2CB PPP2R2A PPP2R2C PPP2R2D PPP4C TCP1	P15924 P17987 P26038 P40227 P49368 P50991 P60510 P62714 P63151 P67775 P78318 P78371 Q66LE6 Q99832 Q9Y2T4	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4540
	MSN	P26038	4	PDB	PDB:8citPDB:8cirPDB:1ef1
	CDV3 MSN	P26038 Q9UKY7	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western blottingR SequencingFlow cytometry	1	37452413

Sequence, Structure & Domains12

Sequences

Length

577

Mass

67,820

Sequence

MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM

3D Structural Models

Turn

139..141; 144..149; 179..181; 199..202; 334..337

Helix

26..37; 42..44; 89..92; 96..111; 119..134; 155..160; 165..178; 184..195; 242..244; 274..295; 300..311; 340..343; 504..507; 511..514; 516..530; 540..550; 555..562; 567..575

Beta Strand

5..10; 15..20; 45..51; 56..58; 63..65; 68..70; 74..82; 204..210; 215..221; 224..229; 233..235; 237..241; 245..251; 254..261; 267..270

3D Structure

X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias

375..401; Basic and acidic residues; 476..487; Acidic residues; 492..518; Basic and acidic residues

Motif

115..120; [IL]-x-C-x-x-[DE] motif

Domain (CC)

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.

Domain (FT)

2..295; FERM

Region

323..342; Disordered; 375..409; Disordered; 466..518; Disordered

Clinical Relevance5

Disease Involvement (2)

Cancer-related genesDisease variant

Antibody (7)

HPA000263 CAB010898 HPA011135 HPA011227 CAB047336 CAB047337 CAB047338

Interaction Protein (2)

ENSG00000026508ENSG00000092820

Interaction Count

2

Interaction Dataset (2)

intact_biogridbiogrid_opencell_bioplex

Supporting Publications2

PMID	Title	Abstract
36573687	Proteomic and phosphoproteomic landscape of salivary extracellular vesicles to assess OSCC therapeutical outcomes.	No abstract available
38037300	Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles.	No abstract available

Entry name MOES	UniProt ID P26038	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

MOES