Protein detail

NKG2D

NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

Entry name NKG2D	UniProt ID P26718	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count 1	Protein classification Cancer-related genesCD markersPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

NKG2-D type II integral membrane protein (Killer cell lectin-like receptor subfamily K member 1) (NK cell receptor D) (NKG2-D-activating NK receptor) (CD antigen CD314)

Protein Class (4)

Cancer-related genesCD markersPredicted membrane proteinsTransporters

Protein Function (3)

Transporters:Transporter channels and pores
Cancer-related genes:Candidate cancer biomarkers
CD markers

Transmembrane

52..72; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000213809

Entrez Gene Symbol

KLRK1

Gene Synonym (5)

CD314D12S2489EKLRNKG2-DNKG2D

Gene Description

Killer cell lectin like receptor K1

Chromosome

Position

10372353-10391874

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificEsophageal apical cellsBlood Cell Specificbasophil

Function & Pathway8

Protein Function (3)

Transporters:Transporter channels and pores
Cancer-related genes:Candidate cancer biomarkers
CD markers

Cellular Component (4)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Reactome (5)

Canonical Pathways (3)

M1315 Sig pip3 signaling in b lymphocytes
M8626 Sig bcr signaling pathway
M10 Pid bcr 5pathway

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence52

Ligand-Receptor Signaling (49)

49 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ULBP2	Q9BZM5	NKG2D	P26718	Yes	Yes	No	HPMRCellChatDBFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020IntActWangLRdbHPMR_talklr	LRdb:10894171 HPMR:10894171 IntAct:28559451 CellTalkDB:10894171 CellChatDB:24223577 IntAct:19424970 connectomeDB2020:10894171 connectomeDB2020:26041808 SIGNOR:10894171

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	KLRK1	P26718	2	PDB	PDB:8ea6PDB:9dh2PDB:8ea8PDB:8se6PDB:8se5PDB:8ea7PDB:8ea5PDB:8ea9PDB:8eabPDB:8eaa

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	4	40689422 40596376 38037300 39702169

Sequence, Structure & Domains9

Sequences

Length

216

Mass

25,304

Sequence

MGWIRGRRSRHSWEMSEFHNYNLDLKKSDFSTRWQKQRCPVVKSKCRENASPFFFCCFIAVAMGIRFIIMVTIWSAVFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

Alternative Products

Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms are produced.; Name=1; IsoId=P26718-1; Sequence=Displayed

3D Structural Models

Turn

129..131; 140..143; 161..163; 194..196

Helix

120..128; 144..148

Beta Strand

94..96; 103..106; 109..118; 133..135; 153..159; 166..168; 176..178; 180..182; 185..193; 197..201; 207..213

3D Structure

X-ray crystallography (8)

Domain & Motif Annotations

Domain (FT)

98..213; C-type lectin

Clinical Relevance6

Disease Involvement

Cancer-related genes

Related Diseases (6)

Acute myeloid leukaemia Colorectal cancer Crohn disease Multiple myeloma Myelodysplastic syndrome Rheumatoid arthritis

Biomarker

Phase 1; Phase 2; Discontinued in Phase 2

Drug Targets

Clinical trial target

Drugs (5)

RIBAVIRIN AUTOLOGOUS NKG2D CAR-CD3ZETA-DAP10-EXPRESSING T-LYMPHOCYTES CYAD-01 TESNATILIMAB NULL PEGINTERFERON ALFA-2B

Antibody (2)

CAB021896 HPA068877

Supporting Publications5

PMID	Title	Abstract
27601599	Comprehensive Proteomic Analysis of Human Milk-derived Extracellular Vesicles Unveils a Novel Functional Proteome Distinct from Other Milk Components.	No abstract available
31070281	The Proteome of Pancreatic Cancer-Derived Exosomes Reveals Signatures Rich in Key Signaling Pathways.	No abstract available
32396726	Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification.	No abstract available
38416841	APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model.	No abstract available
40740986	Proteomics analysis reveals elevated RAB21 in serum-derived extracellular vesicles from patients with follicular thyroid carcinoma.	No abstract available