Protein detail

STOM

Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)

Entry name STOM	UniProt ID P27105	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)

Protein Class (3)

Plasma proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Ensembl

ENSG00000148175

Entrez Gene Symbol

STOM

Gene Synonym (3)

BND7EPB7EPB72

Gene Description

Stomatin

Chromosome

Position

121338987-121370304

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificepididymisCell SpecificEnterocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway7

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

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Molecular Function (5)

Biological Process (3)

Reactome (14)

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Canonical Pathways (2)

M277 Pid integrin a4b1 pathway
M18 Pid integrin1 pathway

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence41

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
STOM	PRKACA	P17612	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
STOM	PRKX	P51817	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
STOM	PRKY	O43930	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STOM	P27105	GTR1	P11166	Yes	No	Yes	HPRDMPPISIGNOR	MPPI:10562431 HPRD:10562431 SIGNOR:10562431

Protein Complex Composition (14)

14 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster116	DDOST JAGN1 SSR3 STOM STOML3	P27105 P39656 Q8N5M9 Q8TAV4 Q9UNL2	1:1:1:1:1	Compleat	Compleat:HC278	22036573
	AHSA1 ALG2 ETFA GMDS LDHA MT-CO2 NUP50 RAB1A RAB2A RAB5A RAP1A SSR1 SSR4 STOM TSPO	B1AH88 O60547 O95433 P00338 P00403 P13804 P20339 P27105 P43307 P51571 P61019 P62820 P62834 Q9H553 Q9UKX7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5828
	AHSA1 ETFA GMDS KDELR2 MT-CO2 RAB1A RAB2A RAB5A RAB6A RAB7A RABGGTB RDH13 RPN1 STOM TSPO	B1AH88 O60547 O95433 P00403 P04843 P13804 P20339 P20340 P27105 P33947 P51149 P53611 P61019 P62820 Q8NBN7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6934
	GOLT1B MT-ND1 MT-ND4 MT-ND5 NDUFA1 NDUFA10 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAF3 NDUFAF4 NDUFB1 NDUFB10 NDUFB11 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 STOML2 UQCRFS1	O00217 O15239 O43181 O43674 O43676 O43678 O43920 O75251 O75306 O75380 O75438 O75489 O95139 O95167 O95168 O95169 O95182 O95299 O96000 P03886 P03905 P03915 P17568 P19404 P28331 P47985 P49821 P51970 P56181 P56556 Q16718 Q16795 Q9BU61 Q9NX14 Q9P032 Q9P0J0 Q9UI09 Q9UJZ1 Q9Y3E0 Q9Y6M9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CCNA1 EIF1B EIF3D EIF3F EIF3H EIF3K EIF3L EIF3M EIF4A2 EIF4H STOML2	O00303 O15371 O15372 O60739 P78396 Q14240 Q15056 Q7L2H7 Q9UBQ5 Q9UJZ1 Q9Y262	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7671
	GOLT1B MT-ND1 MT-ND5 NDUFA12 NDUFA2 NDUFA7 NDUFA8 NDUFA9 NDUFB10 NDUFB11 NDUFB5 NDUFB7 NDUFB8 NDUFB9 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS6 NDUFV1 NDUFV2 NDUFV3 STOML2 UQCRFS1	O43181 O43674 O43678 O75306 O75380 O75489 O95169 O95182 O96000 P03886 P03915 P17568 P19404 P28331 P47985 P49821 P51970 P56181 Q16795 Q9NX14 Q9UI09 Q9UJZ1 Q9Y3E0 Q9Y6M9	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	NDUFA2 NDUFS1 NDUFV2 STOML2	O43678 P19404 P28331 Q9UJZ1	0:0:0:0	hu.MAP2
	NDUFA2 STOML2	O43678 Q9UJZ1	0:0	hu.MAP
	AHSA1 ARL8B HSD17B12 JAK2 KDELR2 RAB1A RAB2A RAB5A RAB6A RAB7A RABGGTB RHEB RPN1 SSR2 STOM	O60674 O95433 P04843 P20339 P20340 P27105 P33947 P43308 P51149 P53611 P61019 P62820 Q15382 Q53GQ0 Q9NVJ2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4099
	CASP7 EIF2S2 HSD17B12 JAK2 KDELR2 RAB1A RAB2A RAB5B RAB6A RAB7A RDH13 REEP5 RPN1 SSR2 STOM	O60674 P04843 P20042 P20340 P27105 P33947 P43308 P51149 P55210 P61019 P61020 P62820 Q00765 Q53GQ0 Q8NBN7	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8252

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	37786918 40748658 34817906 27894104 33709510

Sequence, Structure & Domains12

Sequences

Length

288

Mass

31,731

Sequence

MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27105-1; Sequence=Displayed; Name=2; IsoId=P27105-2; Sequence=VSP_044669

Alternative Sequence

55..219; Missing (in isoform 2)

3D Structural Models

Turn

184..186

Helix

129..134; 136..156; 160..163; 167..183

Beta Strand

99..109; 115..127; 187..197

3D Structure

Electron microscopy (1); NMR spectroscopy (1)

Domain & Motif Annotations

Region

1..22; Disordered; 265..273; Required for homooligomerization; 267..269; Required for lipid raft association; 273..287; Interaction with LANCL1

Protein Families

Band 7/mec-2 family

Sequence Similarities

Belongs to the band 7/mec-2 family.

Clinical Relevance5

Drugs (9)

SR8185 MRT67307 BX-795 GSK8612 BAY-985 AMLEXANOX COMPOUND II [PMID: 21329883]COMPOUND 17D [PMID: 23099093]MPI-0485520

Antibody (2)

HPA010961 HPA011419

Interaction Protein (5)

ENSG00000100243ENSG00000120802ENSG00000136238ENSG00000167863ENSG00000241837

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32396726	Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification.	No abstract available