Protein detail
STOM
Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)
Entry name STOM | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification Plasma proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)
Protein Class
Plasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym
BND7EPB7EPB72
Gene Description
Stomatin
Chromosome
9
Position
121338987-121370304
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificEnterocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0005615 extracellular space
- GO:0005739 mitochondrion
- GO:0005783 endoplasmic reticulum
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0031982 vesicle
- GO:0035577 azurophil granule membrane
- GO:0035579 specific granule membrane
- GO:0042470 melanosome
- GO:0045121 membrane raft
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0070821 tertiary granule membrane
- GO:0072562 blood microparticle
Molecular Function
Biological Process
Reactome
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-168249 innate immune system
- R-hsa-983712 ion channel transport
- R-hsa-6798695 neutrophil degranulation
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013407 rhoh gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
- R-hsa-9012999 rho gtpase cycle
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-2672351 stimuli sensing channels
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M277 Pid integrin a4b1 pathway
- M18 Pid integrin1 pathway
Mediation Categories
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| STOM | PRKACA | P17612 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| STOM | PRKX | P51817 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| STOM | PRKY | O43930 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STOM | P27105 | GTR1 | P11166 | Yes | No | Yes | HPRDMPPISIGNOR | MPPI:10562431HPRD:10562431SIGNOR:10562431 |
Protein Complex Composition
14 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AHSA1ARL8AETFAHSD17B12KDELR2RAB1ARAB2ARAB5BRAB6ARAB7ARABGGTBRHEBRPN1SSR2STOM | O95433P04843P13804P20340P27105P33947P43308P51149P53611P61019P61020P62820Q15382Q53GQ0Q96BM9 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6156 | ||
| MT-ND1NDUFA9NDUFB10NDUFS1NDUFV2SLC25A11STOML2 | O96000P03886P19404P28331Q02978Q16795Q9UJZ1 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| GLIS2IPO9MT-CO2SLC6A15STOMUQCRC2 | P00403P22695P27105Q96P70Q9BZE0Q9H2J7 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9380 | ||
| ATP5PBCERS2DNAJC28MT-ATP8NDUFA9STOML2 | P03928P24539Q16795Q96G23Q9NX36Q9UJZ1 | 0:0:0:0:0:0 | hu.MAP2 |
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Isolation & Detection Technology
Sequence, Structure & Domains
Sequences
Length
288
Mass
31,731
Sequence
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27105-1; Sequence=Displayed; Name=2; IsoId=P27105-2; Sequence=VSP_044669
Alternative Sequence
55..219; Missing (in isoform 2)
3D Structural Models
Turn
184..186
Helix
129..134; 136..156; 160..163; 167..183
Beta Strand
99..109; 115..127; 187..197
3D Structure
Electron microscopy (1); NMR spectroscopy (1)
Domain & Motif Annotations
Region
1..22; Disordered; 265..273; Required for homooligomerization; 267..269; Required for lipid raft association; 273..287; Interaction with LANCL1
Protein Families
Band 7/mec-2 family
Sequence Similarities
Belongs to the band 7/mec-2 family.
Clinical Relevance
Drugs
Interaction Protein
ENSG00000100243ENSG00000120802ENSG00000136238ENSG00000167863ENSG00000241837
Interaction Count
5
Interaction Dataset
intact_biogrid