Protein detail

STOM

Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)

Entry name STOM	UniProt ID P27105	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)

Protein Class (3)

Plasma proteinsPredicted membrane proteinsTransporters

Protein Function

Transporters:Accessory Factors Involved in Transport

Ensembl

ENSG00000148175

Entrez Gene Symbol

STOM

Gene Synonym (3)

BND7EPB7EPB72

Gene Description

Stomatin

Chromosome

Position

121338987-121370304

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue SpecificepididymisCell SpecificEnterocytesSingle-Nuclei Brain Specificastrocyte

Function & Pathway7

Protein Function

Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

Reactome (14)

Page 1 of 2

Canonical Pathways (2)

M277 Pid integrin a4b1 pathway
M18 Pid integrin1 pathway

Mediation Categories (3)

Fusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence41

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
STOM	PRKACA	P17612	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
STOM	PRKX	P51817	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
STOM	PRKY	O43930	S	10	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

Ligand-Receptor Signaling (22)

22 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
STOM	P27105	GTR1	P11166	Yes	No	Yes	HPRDMPPISIGNOR	MPPI:10562431 HPRD:10562431 SIGNOR:10562431

Protein Complex Composition (14)

14 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AHSA1 ARL8A ETFA HSD17B12 KDELR2 RAB1A RAB2A RAB5B RAB6A RAB7A RABGGTB RHEB RPN1 SSR2 STOM	O95433 P04843 P13804 P20340 P27105 P33947 P43308 P51149 P53611 P61019 P61020 P62820 Q15382 Q53GQ0 Q96BM9	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6156
MT-ND1 NDUFA9 NDUFB10 NDUFS1 NDUFV2 SLC25A11 STOML2	O96000 P03886 P19404 P28331 Q02978 Q16795 Q9UJZ1	0:0:0:0:0:0:0	hu.MAP2
GLIS2 IPO9 MT-CO2 SLC6A15 STOM UQCRC2	P00403 P22695 P27105 Q96P70 Q9BZE0 Q9H2J7	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9380
ATP5PB CERS2 DNAJC28 MT-ATP8 NDUFA9 STOML2	P03928 P24539 Q16795 Q96G23 Q9NX36 Q9UJZ1	0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationDensity Gradient CentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	5	37786918 40748658 34817906 27894104 33709510

Sequence, Structure & Domains12

Sequences

Length

288

Mass

31,731

Sequence

MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27105-1; Sequence=Displayed; Name=2; IsoId=P27105-2; Sequence=VSP_044669

Alternative Sequence

55..219; Missing (in isoform 2)

3D Structural Models

Turn

184..186

Helix

129..134; 136..156; 160..163; 167..183

Beta Strand

99..109; 115..127; 187..197

3D Structure

Electron microscopy (1); NMR spectroscopy (1)

Domain & Motif Annotations

Region

1..22; Disordered; 265..273; Required for homooligomerization; 267..269; Required for lipid raft association; 273..287; Interaction with LANCL1

Protein Families

Band 7/mec-2 family

Sequence Similarities

Belongs to the band 7/mec-2 family.

Clinical Relevance5

Drugs (9)

SR8185 MRT67307 BX-795 GSK8612 BAY-985 AMLEXANOX COMPOUND II [PMID: 21329883]COMPOUND 17D [PMID: 23099093]MPI-0485520

Antibody (2)

HPA010961 HPA011419

Interaction Protein (5)

ENSG00000100243ENSG00000120802ENSG00000136238ENSG00000167863ENSG00000241837

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
32396726	Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification.	No abstract available