Protein detail
STOM
Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)
Entry name STOM | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Plasma proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Stomatin (Erythrocyte band 7 integral membrane protein) (Erythrocyte membrane protein band 7.2) (Protein 7.2b)
Protein Class (3)
Plasma proteinsPredicted membrane proteinsTransporters
Protein Function
Transporters:Accessory Factors Involved in Transport
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
BND7EPB7EPB72
Gene Description
Stomatin
Chromosome
9
Position
121338987-121370304
Supporting publications (n)
1
EVMP confidence score
0.28
Fluorescence & Localization
Tissue SpecificepididymisCell SpecificEnterocytesSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
Transporters:Accessory Factors Involved in Transport
Cellular Component (15)
- GO:0005615 extracellular space
- GO:0005739 mitochondrion
- GO:0005783 endoplasmic reticulum
- GO:0005856 cytoskeleton
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0031982 vesicle
- GO:0035577 azurophil granule membrane
- GO:0035579 specific granule membrane
- GO:0042470 melanosome
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Molecular Function (5)
Biological Process (3)
Reactome (14)
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-168249 innate immune system
- R-hsa-983712 ion channel transport
- R-hsa-6798695 neutrophil degranulation
- R-hsa-8980692 rhoa gtpase cycle
- R-hsa-9013026 rhob gtpase cycle
- R-hsa-9013106 rhoc gtpase cycle
- R-hsa-9013407 rhoh gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-9013406 rhoq gtpase cycle
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Canonical Pathways (2)
- M277 Pid integrin a4b1 pathway
- M18 Pid integrin1 pathway
Mediation Categories (3)
Fusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence41
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| STOM | PRKACA | P17612 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| STOM | PRKX | P51817 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| STOM | PRKY | O43930 | S | 10 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP |
Ligand-Receptor Signaling (22)
22 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane_predicted | transmembrane | OmniPath | |||||
| transmembrane | transmembrane | LOCATE | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| peripheral | peripheral | UniProt_topology | |||||
| peripheral | peripheral | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| transmembrane | transmembrane_predicted | Phobius | |||||
| transmembrane_phobius | transmembrane_predicted | Almen2009 |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| STOM | P27105 | GTR1 | P11166 | Yes | Yes | HPRDMPPISIGNOR | MPPI:10562431HPRD:10562431SIGNOR:10562431 |
Protein Complex Composition (14)
14 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| AHSA1ARL8AETFAHSD17B12KDELR2RAB1ARAB2ARAB5BRAB6ARAB7ARABGGTBRHEBRPN1SSR2STOM | O95433P04843P13804P20340P27105P33947P43308P51149P53611P61019P61020P62820Q15382Q53GQ0Q96BM9 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6156 | ||
| MT-ND1NDUFA9NDUFB10NDUFS1NDUFV2SLC25A11STOML2 | O96000P03886P19404P28331Q02978Q16795Q9UJZ1 | 0:0:0:0:0:0:0 | hu.MAP2 | |||
| GLIS2IPO9MT-CO2SLC6A15STOMUQCRC2 | P00403P22695P27105Q96P70Q9BZE0Q9H2J7 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9380 | ||
| ATP5PBCERS2DNAJC28MT-ATP8NDUFA9STOML2 | P03928P24539Q16795Q96G23Q9NX36Q9UJZ1 | 0:0:0:0:0:0 | hu.MAP2 |
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Isolation & Detection Technology (1)
Sequence, Structure & Domains
Sequences
Length
288
Mass
31,731
Sequence
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P27105-1; Sequence=Displayed; Name=2; IsoId=P27105-2; Sequence=VSP_044669
Alternative Sequence
55..219; Missing (in isoform 2)
3D Structural Models
Turn
184..186
Helix
129..134; 136..156; 160..163; 167..183
Beta Strand
99..109; 115..127; 187..197
3D Structure
Electron microscopy (1); NMR spectroscopy (1)
Domain & Motif Annotations
Region
1..22; Disordered; 265..273; Required for homooligomerization; 267..269; Required for lipid raft association; 273..287; Interaction with LANCL1
Protein Families
Band 7/mec-2 family
Sequence Similarities
Belongs to the band 7/mec-2 family.
Clinical Relevance
Drugs (9)
Interaction Protein (5)
ENSG00000100243ENSG00000120802ENSG00000136238ENSG00000167863ENSG00000241837
Interaction Count
5
Interaction Dataset
intact_biogrid
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32396726 | Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification. | No related sentences available |