Protein detail

PTPRM

Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)

Entry name PTPRM	UniProt ID P28827	EVMP confidence score 0.50
Supporting publications (n) 3	Transmembrane count 1	Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)

Protein Class (4)

EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Transmembrane

743..764; Helical

Transmembrane Count

Ensembl

ENSG00000173482

Entrez Gene Symbol

PTPRM

Gene Synonym (3)

hR-PTPuPTPRL1RPTPU

Gene Description

Protein tyrosine phosphatase receptor type M

Chromosome

Position

7566782-8406861

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificmidbrain-derived inhibitory

Function & Pathway7

Protein Function (3)

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component (6)

Molecular Function (6)

Biological Process (3)

KEGG (2)

Canonical Pathways

M110 Pid il1 pathway

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence64

Ligand-Receptor Signaling (60)

60 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	Membranome	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	connectomeDB2020	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
ligand	ligand	ICELLNET	Yes	No	No	Yes	No

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Regulatory Interaction Network (2)

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTPRM	P28827	CTND1	O60716	Yes	Yes	Yes	SIGNORDEPODHPRDWangSPIKE_LC	DEPOD:10753936 HPRD:15588985 SIGNOR:21998202 HPRD:10753936
PTPRM	P28827	STAT3	P40763	Yes	No	Yes	REACH_ProtMapperSIGNORProtMapper	SIGNOR:31900385 ProtMapper:31900385

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTPRM	P28827	2	PDB	PDB:1rpmPDB:8a16PDB:8a17

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains12

Sequences

Length

1,452

Mass

163,682

Sequence

MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28827-1; Sequence=Displayed; Name=2; IsoId=P28827-2; Sequence=VSP_046677

Alternative Sequence

842; P -> PDPFVPTAILVPIN (in isoform 2)

3D Structural Models

Turn

53..55; 653..656; 882..884; 916..919; 949..952

Helix

33..36; 252..254; 405..408; 487..489; 533..535; 649..652; 885..905; 921..926; 936..938; 976..978; 979..988; 1071..1083; 1100..1118; 1123..1133; 1141..1155

Beta Strand

29..31; 42..45; 49..52; 66..72; 81..85; 96..104; 106..109; 111..120; 129..132; 140..147; 155..163; 169..180; 183..185; 194..196; 198..200; 202..210; 217..222; 230..237; 240..247; 256..264; 267..278; 284..286; 289..293; 298..301; 305..309; 315..326; 328..332; 335..340; 348..356; 370..373; 384..391; 396..401; 410..412; 414..434; 443..446; 454..462; 467..469; 473..476; 491..494; 499..502; 513..526; 536..544; 546..550; 557..567; 575..580; 597..599; 604..608; 614..616; 620..627; 632..636; 658..666; 674..678; 698..708; 711..722; 939..941; 953..961; 964..971; 993..996; 1000..1002; 1014..1019; 1022..1032; 1035..1044; 1051..1058; 1063..1065; 1091..1099; 1119..1121

3D Structure

X-ray crystallography (5)

Domain & Motif Annotations

Domain (FT)

22..184; MAM; 186..277; Ig-like C2-type; 284..379; Fibronectin type-III 1; 382..480; Fibronectin type-III 2; 482..587; Fibronectin type-III 3; 589..671; Fibronectin type-III 4; 900..1154; Tyrosine-protein phosphatase 1; 1186..1448; Tyrosine-protein phosphatase 2

Protein Families (2)

Protein-tyrosine phosphatase family
Receptor class 2B subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.

Clinical Relevance2

Drugs

COMPOUND 8A [PMID: 23713581]

Antibody (3)

HPA003891 CAB022442 CAB022443

Supporting Publications3

PMID	Title	Abstract
28240915	Quantitative Proteomic Analysis of Serum Exosomes from Patients with Locally Advanced Pancreatic Cancer Undergoing Chemoradiotherapy.	No abstract available
33017416	Proteomic analysis of plasma exosomes from Cystic Echinococcosis patients provides in vivo support for distinct immune response profiles in active vs inactive infection and suggests potential biomarkers.	No abstract available
33169421	A novel method of high-purity extracellular vesicle enrichment from microliter-scale human serum for proteomic analysis.	No abstract available