Protein detail
PTPRM
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
Protein symbol PTPRM | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 1 | Protein classification EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)
Protein Class
EnzymesPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Transmembrane
743..764; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
hR-PTPuPTPRL1RPTPU
Gene Description
Protein tyrosine phosphatase receptor type M
Chromosome
18
Position
7566782-8406861
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificmidbrain-derived inhibitory
Function & Pathway
Protein Function
- Enzymes
- Predicted intracellular proteins
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
M110 Pid il1 pathway
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
60 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
| receptor | receptor | scConnect | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| receptor | receptor | iTALK | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor_tyrosine_phosphatase | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PTPRM | P28827 | CTND1 | O60716 | Yes | Yes | Yes | SIGNORDEPODHPRDWangSPIKE_LC | DEPOD:10753936HPRD:15588985SIGNOR:21998202HPRD:10753936 |
| PTPRM | P28827 | STAT3 | P40763 | Yes | No | Yes | REACH_ProtMapperSIGNORProtMapper | SIGNOR:31900385ProtMapper:31900385 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
1,452
Mass
163,682
Sequence
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28827-1; Sequence=Displayed; Name=2; IsoId=P28827-2; Sequence=VSP_046677
Alternative Sequence
842; P -> PDPFVPTAILVPIN (in isoform 2)
3D Structural Models
Turn
53..55; 653..656; 882..884; 916..919; 949..952
Helix
33..36; 252..254; 405..408; 487..489; 533..535; 649..652; 885..905; 921..926; 936..938; 976..978; 979..988; 1071..1083; 1100..1118; 1123..1133; 1141..1155
Beta Strand
29..31; 42..45; 49..52; 66..72; 81..85; 96..104; 106..109; 111..120; 129..132; 140..147; 155..163; 169..180; 183..185; 194..196; 198..200; 202..210; 217..222; 230..237; 240..247; 256..264; 267..278; 284..286; 289..293; 298..301; 305..309; 315..326; 328..332; 335..340; 348..356; 370..373; 384..391; 396..401; 410..412; 414..434; 443..446; 454..462; 467..469; 473..476; 491..494; 499..502; 513..526; 536..544; 546..550; 557..567; 575..580; 597..599; 604..608; 614..616; 620..627; 632..636; 658..666; 674..678; 698..708; 711..722; 939..941; 953..961; 964..971; 993..996; 1000..1002; 1014..1019; 1022..1032; 1035..1044; 1051..1058; 1063..1065; 1091..1099; 1119..1121
3D Structure
X-ray crystallography (5)
Domain & Motif Annotations
Domain (FT)
22..184; MAM; 186..277; Ig-like C2-type; 284..379; Fibronectin type-III 1; 382..480; Fibronectin type-III 2; 482..587; Fibronectin type-III 3; 589..671; Fibronectin type-III 4; 900..1154; Tyrosine-protein phosphatase 1; 1186..1448; Tyrosine-protein phosphatase 2
Protein Families
- Protein-tyrosine phosphatase family
- Receptor class 2B subfamily
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.