Protein detail
CD34
Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)
Protein symbol CD34 | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
Basic Information
Protein Names
Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)
Protein Class
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
291..311; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Description
CD34 molecule
Chromosome
1
Position
207880972-207911402
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificErythrocyte progenitors
Function & Pathway
Protein Function
CD markers
Cellular Component
- GO:0005576 extracellular region
- GO:0005737 cytoplasm
- GO:0005764 lysosome
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0009925 basal plasma membrane
- GO:0016324 apical plasma membrane
- GO:0036053 glomerular endothelium fenestra
- GO:0045171 intercellular bridge
- GO:0048471 perinuclear region of cytoplasm
Molecular Function
Biological Process
Reactome
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
47 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | Baccin2019 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| ligand | ligand | talklr | Yes | No | No | Yes | No |
| ligand | ligand | iTALK | Yes | No | No | Yes | No |
| ligand | ligand | EMBRACE | Yes | No | No | Yes | No |
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | No | Yes | No |
| ligand | ligand | Ramilowski2015 | Yes | No | No | Yes | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
385
Mass
40,716
Sequence
MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation.; Name=CD34-F; IsoId=P28906-1; Sequence=Displayed; Name=CD34-T; IsoId=P28906-2; Sequence=VSP_004159, VSP_004160
Alternative Sequence
325..328; GEDP -> ELEP (in isoform CD34-T); 329..385; Missing (in isoform CD34-T)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
127..142; Polar residues; 144..159; Low complexity; 357..374; Polar residues
Region
127..159; Disordered; 321..385; Disordered
Protein Families
CD34 family
Sequence Similarities
Belongs to the CD34 family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1; Phase 2
Drugs