Protein detail

CD34

Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)

Entry name CD34	UniProt ID P28906	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 1	Protein classification CD markersPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information12

Protein Names

Hematopoietic progenitor cell antigen CD34 (CD antigen CD34)

Protein Class (2)

CD markersPredicted membrane proteins

Protein Function

CD markers

Transmembrane

291..311; Helical

Transmembrane Count

Ensembl

ENSG00000174059

Entrez Gene Symbol

CD34

Gene Description

CD34 molecule

Chromosome

Position

207880972-207911402

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificErythrocyte progenitors

Function & Pathway7

Protein Function

CD markers

Cellular Component (10)

Molecular Function (4)

Biological Process (3)

KEGG (2)

Reactome (2)

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence48

Ligand-Receptor Signaling (47)

47 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ligand	ligand	LRdb	Yes	No	No	Yes	No
cell_adhesion	ligand	ICELLNET	Yes	No	No	Yes	No
ligand	ligand	OmniPath	Yes	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	Yes	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	Yes	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains9

Sequences

Length

385

Mass

40,716

Sequence

MLVRRGARAGPRMPRGWTALCLLSLLPSGFMSLDNNGTATPELPTQGTFSNVSTNVSYQETTTPSTLGSTSLHPVSQHGNEATTNITETTVKFTSTSVITSVYGNTNSSVQSQTSVISTVFTTPANVSTPETTLKPSLSPGNVSDLSTTSTSLATSPTKPYTSSSPILSDIKAEIKCSGIREVKLTQGICLEQNKTSSCAEFKKDRGEGLARVLCGEEQADADAGAQVCSLLLAQSEVRPQCLLLVLANRTEISSKLQLMKKHQSDLKKLGILDFTEQDVASHQSYSQKTLIALVTSGALLAVLGITGYFLMNRRSWSPTGERLGEDPYYTENGGGQGYSSGPGTSPEAQGKASVNRGAQENGTGQATSRNGHSARQHVVADTEL

Alternative Products

Event=Alternative splicing; Named isoforms=2; Comment=Both isoforms are expressed on the cell surface. CD34-T/CD34-F ratio increases with cell differentiation.; Name=CD34-F; IsoId=P28906-1; Sequence=Displayed; Name=CD34-T; IsoId=P28906-2; Sequence=VSP_004159, VSP_004160

Alternative Sequence

325..328; GEDP -> ELEP (in isoform CD34-T); 329..385; Missing (in isoform CD34-T)

Domain & Motif Annotations

Compositional Bias

127..142; Polar residues; 144..159; Low complexity; 357..374; Polar residues

Region

127..159; Disordered; 321..385; Disordered

Protein Families

CD34 family

Sequence Similarities

Belongs to the CD34 family.

Clinical Relevance4

Related Diseases (3)

Acute myeloid leukaemia Heart failure Myelodysplastic syndrome

Biomarker

Phase 1; Phase 2

Drugs (10)

DIFFERENTIATION INDUCER PUROMYCIN YM-244769 GP-120 ANTIGEN AUTOLOGOUS BONE MARROW-DERIVED CD34/CXCR4-POSITIVE STEM CELLS AMR-001 ALITRETINOIN PREDNISOLONE QUERCETIN FLUORODEOXYGLUCOSE F18 BOVINE PITUITARY EXTRACT

Antibody (3)

CAB000018 HPA036722 HPA036723

Supporting Publications4

PMID	Title	Abstract
21835908	Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity.	CD34(+) exosomes may represent a significant component of the paracrine effect of progenitor cell transplantation for therapeutic angiogenesis. CONCLUSIONS: Our data demonstrate that human CD34(+) cells secrete exosomes that have independent angiogenic activity both in vitro and in vivo. In vitro, CD34(+) exosomes replicated the angiogenic activity of CD34(+) cells by increasing endothelial cell viability, proliferation, and tube formation on Matrigel. In vivo, the CD34(+) exosomes stimulated angiogenesis in Matrigel plug and corneal assays. Interestingly, exosomes from CD34(+) cells but not from CD34(+) cell-depleted mononuclear cells had angiogenic activity. METHODS AND RESULTS: Exosomes collected from the conditioned media of mobilized human CD34(+) cells had the characteristic size (40 to 90 nm; determined by dynamic light scattering), cup-shaped morphology (electron microscopy), expressed exosome-marker proteins CD63, phosphatidylserine (flow cytometry) and TSG101 (immunoblotting), besides expressing CD34(+) cell lineage marker protein, CD34. OBJECTIVE: Our objective was to investigate the mechanism of CD34(+) stem cell-induced proangiogenic paracrine effects and to examine if exosomes, a component of paracrine secretion, are involved.
38173016	Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging.	No abstract available
38762017	Preliminary study on the mechanism by which exosomes derived from human exfoliated deciduous teeth improve the proliferation and osteogenic inhibitory effect of glucocorticoid-induced BMSCs.	In conclusion, SHED-derived exosomes partially reversed the inhibitory effects of glucocorticoids on BMSC proliferation and osteogenesis by inhibiting the expression of HGF, ITGB8 and IL7, and upregulating the expression of EFNA1. Transcriptome sequencing analysis revealed that the differentially expressed mRNAs regulated by SHED-derived exosomes were enriched mainly in signaling pathways such as the apoptosis pathway, the PI3K-Akt signaling pathway, the Hippo signaling pathway and the p53 signaling pathway.
39166055	Dental pulp stem cells regenerate neural tissue in degenerative disorders and stroke rehabilitation: A scope systematic review.	DPSC-derived exosomes suppressed the expression of IL-6, IL-1β, TNF-α, and TGF, key mediators of nerve tissue inflammation.