Protein detail

CD38

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)

Entry name CD38	UniProt ID P28907	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (5)

Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
CD markers
Enzymes
Cancer-related genes:Candidate cancer biomarkers
ENZYME proteins:Hydrolases

Transmembrane

22..42; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000004468

Entrez Gene Symbol

CD38

Gene Synonym

cADPR1

Gene Description

CD38 molecule

Chromosome

Position

15778275-15853232

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization8

Tissue Specificlymphoid tissueCell SpecificEndometrial secretory cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory CD8 T-cellBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionImmunity

Function & Pathway8

Protein Function (6)

Predicted intracellular proteins
ENZYME proteins:Transferases
CD markers
Enzymes
Cancer-related genes:Candidate cancer biomarkers
ENZYME proteins:Hydrolases

Cellular Component (6)

Molecular Function (5)

Biological Process (3)

KEGG (7)

Reactome (3)

Canonical Pathways

M81 Pid cdc42 pathway

Mediation Categories (5)

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence44

Ligand-Receptor Signaling (41)

41 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PECA1	P16284	CD38	P28907	Yes	Yes	No	CellChatDBCellPhoneDBICELLNETSIGNORconnectomeDB2020HPRDCellPhoneDB_CellinkerBaccin2019CellinkerWangLRdb	ICELLNET:26407101 CellChatDB:26407101 ICELLNET:9551996 connectomeDB2020:26407101 SIGNOR:18626062 Baccin2019:23308177 HPRD:9551996 Cellinker:9551996 LRdb:9551996 connectomeDB2020:9551996

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CD38	P28907	2	PDB	PDB:3romPDB:6vuaPDB:4f45PDB:2o3sPDB:3ropPDB:2hctPDB:3dzhPDB:2pgjPDB:1yh3PDB:3i9mPDB:2i66PDB:2i67PDB:2o3tPDB:2ef1PDB:2i65PDB:2o3qPDB:3dzfPDB:8vauPDB:1zvmPDB:3u4iPDB:3rokPDB:6edrPDB:3dziPDB:3u4hPDB:5f1kPDB:3i9nPDB:3roqPDB:3dzjPDB:3ofsPDB:2o3uPDB:4tmfPDB:2pglPDB:3dzgPDB:3dzkPDB:2o3rPDB:4f46

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	26739763

Sequence, Structure & Domains11

Sequences

Length

300

Mass

34,328

Sequence

MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28907-1; Sequence=Displayed; Name=2; IsoId=P28907-2; Sequence=VSP_000707, VSP_000708

Alternative Sequence

122; I -> K (in isoform 2); 123..300; Missing (in isoform 2)

3D Structural Models

Turn

176..179; 232..234; 291..293

Helix

59..73; 75..77; 82..93; 98..100; 103..106; 107..112; 119..121; 136..141; 145..147; 149..154; 184..199; 221..224; 227..229; 253..255; 257..268; 281..289; 294..296

Beta Strand

51..53; 94..96; 122..127; 132..134; 142..144; 165..167; 171..173; 181..183; 202..209; 212..216; 218..220; 235..243; 246..249; 272..278

3D Structure

Electron microscopy (1); X-ray crystallography (52)

Domain & Motif Annotations

Protein Families

ADP-ribosyl cyclase family

Sequence Similarities

Belongs to the ADP-ribosyl cyclase family.

Clinical Relevance5

Disease Involvement (2)

Cancer-related genesDiabetes mellitus

Related Diseases (11)

Acute myeloid leukaemia B-cell lymphoma Malignant haematopoietic neoplasm Mature B-cell lymphoma Multiple myeloma Myasthenia gravis Myelodysplastic syndrome Postoperative inflammation Solid tumour/cancer Thrombocytopenia Urinary system clinical sympton

Biomarker

Phase 1/2; Approved; Phase 2; Phase 1

Drugs (8)

RITUXIMAB HUMAX-IL15 ISATUXIMAB FELZARTAMAB MEZAGITAMAB THROMBIN AMILORIDE ANTI-CD38 CAR T CELLS PREPARATION

Antibody (4)

CAB002493 HPA022132 CAB025255 HPA052381

Supporting Publications2

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available
35763629	Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers.	No abstract available