Protein detail

CD38

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)

Entry name
CD38
UniProt ID
P28907
EVMP confidence score
0.53
Supporting publications (n)
2
Transmembrane count
1
Protein classification
Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins
Basic Information
Protein Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl cyclase 1) (ADPRC 1) (Cyclic ADP-ribose hydrolase 1) (cADPR hydrolase 1) (T10) (CD antigen CD38)
Protein Class (5)
Cancer-related genesCD markersEnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • ENZYME proteins:Hydrolases
Transmembrane
22..42; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
ENSG00000004468
Entrez Gene Symbol
CD38
Gene Synonym
cADPR1
Gene Description
CD38 molecule
Chromosome
4
Position
15778275-15853232
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
CD38 fluorescence
Tissue Specificlymphoid tissueCell SpecificEndometrial secretory cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory CD8 T-cellBlood Lineage SpecificT-cellsSecretome LocationIntracellular and membraneSecretome FunctionImmunity
Function & Pathway
Protein Function (6)
  • Predicted intracellular proteins
  • ENZYME proteins:Transferases
  • CD markers
  • Enzymes
  • Cancer-related genes:Candidate cancer biomarkers
  • ENZYME proteins:Hydrolases
Cellular Component (6)
Molecular Function (5)
Biological Process (3)
KEGG (7)
Reactome (3)
Canonical Pathways
M81 Pid cdc42 pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence44

Ligand-Receptor Signaling (41)

41 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membraneplasma_membraneOmniPath
cell_surfacecell_surfaceSurfaceome
cell_surfacecell_surfaceconnectomeDB2020
cell_surfacecell_surfaceBaccin2019
cell_surfacecell_surfaceOmniPath
receptorreceptorscConnectYes
receptorreceptorconnectomeDB2020Yes
transmembranetransmembrane_predictedPhobius
transmembrane_phobiustransmembrane_predictedAlmen2009
transmembrane_sosuitransmembrane_predictedAlmen2009
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Regulatory Interaction Network (1)

1 record.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PECA1P16284CD38P28907YesYesCellChatDBCellPhoneDBICELLNETSIGNORconnectomeDB2020HPRDCellPhoneDB_CellinkerBaccin2019CellinkerWangLRdbICELLNET:26407101CellChatDB:26407101ICELLNET:9551996connectomeDB2020:26407101SIGNOR:18626062Baccin2019:23308177HPRD:9551996Cellinker:9551996LRdb:9551996connectomeDB2020:9551996

Protein Complex Composition (1)

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CD38P289072PDBPDB:3romPDB:6vuaPDB:4f45PDB:2o3sPDB:3ropPDB:2hctPDB:3dzhPDB:2pgjPDB:1yh3PDB:3i9mPDB:2i66PDB:2i67PDB:2o3tPDB:2ef1PDB:2i65PDB:2o3qPDB:3dzfPDB:8vauPDB:1zvmPDB:3u4iPDB:3rokPDB:6edrPDB:3dziPDB:3u4hPDB:5f1kPDB:3i9nPDB:3roqPDB:3dzjPDB:3ofsPDB:2o3uPDB:4tmfPDB:2pglPDB:3dzgPDB:3dzkPDB:2o3rPDB:4f46

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry126739763
Sequence, Structure & Domains

Sequences

Length
300
Mass
34,328
Sequence
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P28907-1; Sequence=Displayed; Name=2; IsoId=P28907-2; Sequence=VSP_000707, VSP_000708
Alternative Sequence
122; I -> K (in isoform 2); 123..300; Missing (in isoform 2)

3D Structural Models

Turn
176..179; 232..234; 291..293
Helix
59..73; 75..77; 82..93; 98..100; 103..106; 107..112; 119..121; 136..141; 145..147; 149..154; 184..199; 221..224; 227..229; 253..255; 257..268; 281..289; 294..296
Beta Strand
51..53; 94..96; 122..127; 132..134; 142..144; 165..167; 171..173; 181..183; 202..209; 212..216; 218..220; 235..243; 246..249; 272..278
3D Structure
Electron microscopy (1); X-ray crystallography (52)

Domain & Motif Annotations

Protein Families
ADP-ribosyl cyclase family
Sequence Similarities
Belongs to the ADP-ribosyl cyclase family.
Clinical Relevance
Disease Involvement (2)
Cancer-related genesDiabetes mellitus
Related Diseases (12)
Diabetes mellitusAcute myeloid leukaemiaB-cell lymphomaMalignant haematopoietic neoplasmMature B-cell lymphomaMultiple myelomaMyasthenia gravisMyelodysplastic syndromePostoperative inflammationSolid tumour/cancerThrombocytopeniaUrinary system clinical symptom
Biomarker
Phase 1/2; Approved; Phase 2; Phase 1
Drugs (8)
RITUXIMABHUMAX-IL15ISATUXIMABFELZARTAMABMEZAGITAMABTHROMBINAMILORIDEANTI-CD38 CAR T CELLS PREPARATION
Antibody (4)
CAB002493HPA022132CAB025255HPA052381
Supporting Publications2
PMIDTitleRelated sentences
27487081Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.No related sentences available
35763629Proteomic Profiling of Small Extracellular Vesicles Isolated from the Plasma of Vietnamese Patients with Non-Small Cell Lung Cancer Reveals Some Potential Biomarkers.No related sentences available