Protein detail
CD1B
T-cell surface glycoprotein CD1b (CD antigen CD1b)
Entry name CD1B | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification CD markersPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
T-cell surface glycoprotein CD1b (CD antigen CD1b)
Protein Class (2)
CD markersPredicted membrane proteins
Protein Function
CD markers
Transmembrane
304..324; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD1
Gene Description
CD1b molecule
Chromosome
1
Position
158327951-158331531
Supporting publications (n)
1
EVMP confidence score
0.25
Fluorescence & Localization8
Tissue SpecificbrainCell SpecificBergmann gliaSingle-Nuclei Brain SpecificBergmann gliaBlood Cell SpecificbasophilBlood Lineage SpecificgranulocytesSecretome LocationSecreted - unknown locationSecretome FunctionReceptor
Function & Pathway8
Protein Function
CD markers
Cellular Component (10)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Canonical Pathways
M266 Pid ncadherin pathway
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence40
Ligand-Receptor Signaling (38)
38 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation；Acoustic trapping | Mass spectrometry | 1 | 27487081 |
Sequence, Structure & Domains11
Sequences
Length
333
Mass
36,939
Sequence
MLLLPFQLLAVLFPGGNSEHAFQGPTSFHVIQTSSFTNSTWAQTQGSGWLDDLQIHGWDSDSGTAIFLKPWSKGNFSDKEVAELEEIFRVYIFGFAREVQDFAGDFQMKYPFEIQGIAGCELHSGGAIVSFLRGALGGLDFLSVKNASCVPSPEGGSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSPGPGRLQLVCHVSGFYPKPVWVMWMRGEQEQQGTQLGDILPNANWTWYLRATLDVADGEAAGLSCRVKHSSLEGQDIILYWRNPTSIGSIVLAIIVPSLLLLLCLALWYMRRRSYQNIP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P29016-1; Sequence=Displayed; Name=2; IsoId=P29016-2; Sequence=VSP_016911
Alternative Sequence
242..296; Missing (in isoform 2)
3D Structural Models
Turn
60..63; 70..75; 103..107; 257..259
Helix
78..102; 153..155; 156..166; 172..181; 183..194; 196..199; 271..273; 284..286
Beta Strand
27..38; 41..50; 53..59; 64..67; 110..122; 128..136; 139..145; 148..151; 206..211; 219..232; 235..240; 248..250; 254..256; 260..270; 274..276; 277..282; 291..294
3D Structure
Electron microscopy (1); X-ray crystallography (23)
Domain & Motif Annotations
Motif
329..332; Internalization signal
Domain (FT)
185..295; Ig-like
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 36114323 | Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment. | No abstract available |