Protein detail
GNA11
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Entry name GNA11 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information10
Protein Names
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Protein Class (6)
Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
FBHFBH2FHH2HHC2
Gene Description
G protein subunit alpha 11
Chromosome
19
Position
3094362-3123999
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway8
Protein Function (6)
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
Cellular Component (7)
Molecular Function (8)
Biological Process (3)
KEGG (21)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04540 Gap junction
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04730 Long-term depression
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
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Reactome (23)
- R-hsa-399997 acetylcholine regulates insulin secretion
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-6814122 cooperation of pdcl phlp1 and tric cct in g protein beta folding
- R-hsa-434316 fatty acids bound to gpr40 ffar1 regulate insulin secretion
- R-hsa-400451 free fatty acids regulate insulin secretion
- R-hsa-418594 g alpha i signalling events
- R-hsa-416476 g alpha q signalling events
- R-hsa-202040 g protein activation
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Canonical Pathways (3)
- M36 Pid il27 pathway
- M183 Pid il6 7 pathway
- M100 Pid shp2 pathway
Mediation Categories (4)
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence18
Ligand-Receptor Signaling (11)
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | No | No |
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Regulatory Interaction Network (6)
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA1A | P35348 | GNA11 | P29992 | Yes | Yes | No | WangCui2007SIGNORCA1 | SIGNOR:1334487CA1:1334487 |
| GNA11 | P29992 | PLCB1 | Q9NQ66 | Yes | Yes | No | KEGG-MEDICUSSIGNORCui2007CA1Wang | CA1:12578375SIGNOR:27515033 |
| PLCB1 | Q9NQ66 | GNA11 | P29992 | Yes | Yes | No | WangSIGNOR | SIGNOR:1322796 |
| ADA1B | P35368 | GNA11 | P29992 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:1334487HPRD:9481484 |
| AGTR1 | P30556 | GNA11 | P29992 | Yes | Yes | No | WangSIGNOR | SIGNOR:20181817 |
| TRFR | P34981 | GNA11 | P29992 | Yes | Yes | No | KEGG-MEDICUSWangSIGNOR | SIGNOR:27515033 |
Sequence, Structure & Domains11
Sequences
Length
359
Mass
42,123
Sequence
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
3D Structural Models
Turn
283..285; 288..291
Helix
31..36; 48..50; 52..63; 217..220; 247..259; 276..282; 304..314; 336..355
Beta Strand
39..46; 194..196; 199..205; 213..216; 224..231; 268..274; 324..328
3D Structure
Electron microscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
38..359; G-alpha
Region
41..54; G1 motif; 178..186; G2 motif; 201..210; G3 motif; 270..277; G4 motif; 329..334; G5 motif
Protein Families (2)
- G-alpha family
- G(q) subfamily
Sequence Similarities
Belongs to the G-alpha family. G(q) subfamily.
Clinical Relevance6
Disease Involvement (2)
Cancer-related genesDisease variant
Drugs (10)
Antibody
Interaction Protein
ENSG00000078369
Interaction Count
1
Interaction Dataset
biogrid_opencell