Protein detail
GNA11
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Protein symbol GNA11 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters |
Basic Information
Protein Names
Guanine nucleotide-binding protein subunit alpha-11 (G alpha-11) (G-protein subunit alpha-11) (EC 3.6.5.-) (Guanine nucleotide-binding protein G(y) subunit alpha)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
FBHFBH2FHH2HHC2
Gene Description
G protein subunit alpha 11
Chromosome
19
Position
3094362-3123999
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificadrenal glandCell SpecificAdrenal cortex cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of ion transport and metabolism
- Potential drug targets
- Transporters:Accessory Factors Involved in Transport
- Cancer-related genes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04540 Gap junction
- KEGG:hsa04725 Cholinergic synapse
- KEGG:hsa04730 Long-term depression
- KEGG:hsa04911 Insulin secretion
- KEGG:hsa04912 GnRH signaling pathway
- KEGG:hsa04925 Aldosterone synthesis and secretion
- KEGG:hsa04927 Cortisol synthesis and secretion
- KEGG:hsa04928 Parathyroid hormone synthesis, secretion and action
- KEGG:hsa04929 GnRH secretion
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04935 Growth hormone synthesis, secretion and action
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05146 Amoebiasis
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05170 Human immunodeficiency virus 1 infection
- KEGG:hsa05200 Pathways in cancer
Reactome
- R-hsa-399997 acetylcholine regulates insulin secretion
- R-hsa-418592 adp signalling through p2y purinoceptor 1
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-6814122 cooperation of pdcl phlp1 and tric cct in g protein beta folding
- R-hsa-434316 fatty acids bound to gpr40 ffar1 regulate insulin secretion
- R-hsa-400451 free fatty acids regulate insulin secretion
- R-hsa-418594 g alpha i signalling events
- R-hsa-416476 g alpha q signalling events
- R-hsa-202040 g protein activation
- R-hsa-112040 g protein mediated events
- R-hsa-109582 hemostasis
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-163685 integration of energy metabolism
- R-hsa-111885 opioid signalling
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-391251 protein folding
- R-hsa-422356 regulation of insulin secretion
- R-hsa-372790 signaling by gpcr
- R-hsa-392518 signal amplification
- R-hsa-456926 thrombin signalling through proteinase activated receptors pars
- R-hsa-428930 thromboxane signalling through tp receptor
- R-hsa-9860927 turbulent oscillatory disturbed flow shear stress activates signaling by piezo1 and integrins in endothelial cells
Canonical Pathways
- M36 Pid il27 pathway
- M183 Pid il6 7 pathway
- M100 Pid shp2 pathway
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
6 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA1A | P35348 | GNA11 | P29992 | Yes | Yes | No | WangCui2007SIGNORCA1 | SIGNOR:1334487CA1:1334487 |
| GNA11 | P29992 | PLCB1 | Q9NQ66 | Yes | Yes | No | KEGG-MEDICUSSIGNORCui2007CA1Wang | CA1:12578375SIGNOR:27515033 |
| PLCB1 | Q9NQ66 | GNA11 | P29992 | Yes | Yes | No | WangSIGNOR | SIGNOR:1322796 |
| ADA1B | P35368 | GNA11 | P29992 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:1334487HPRD:9481484 |
| AGTR1 | P30556 | GNA11 | P29992 | Yes | Yes | No | WangSIGNOR | SIGNOR:20181817 |
| TRFR | P34981 | GNA11 | P29992 | Yes | Yes | No | KEGG-MEDICUSWangSIGNOR | SIGNOR:27515033 |
Protein Complex Composition
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
359
Mass
42,123
Sequence
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
3D Structural Models
Turn
283..285; 288..291
Helix
31..36; 48..50; 52..63; 217..220; 247..259; 276..282; 304..314; 336..355
Beta Strand
39..46; 194..196; 199..205; 213..216; 224..231; 268..274; 324..328
3D Structure
Electron microscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Domain (FT)
38..359; G-alpha
Region
41..54; G1 motif; 178..186; G2 motif; 201..210; G3 motif; 270..277; G4 motif; 329..334; G5 motif
Protein Families
- G-alpha family
- G(q) subfamily
Sequence Similarities
Belongs to the G-alpha family. G(q) subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Drugs
Antibody
Interaction Protein
ENSG00000078369
Interaction Count
1
Interaction Dataset
biogrid_opencell