Protein detail

PEBP1

Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]

Entry name PEBP1	UniProt ID P30086	EVMP confidence score 0.75
Supporting publications (n) 36	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000089220

Entrez Gene Symbol

PEBP1

Gene Synonym (4)

HCNPPBPPEBPRKIP

Gene Description

Phosphatidylethanolamine binding protein 1

Chromosome

Position

118136124-118145584

Supporting publications (n)

EVMP confidence score

0.75

Fluorescence & Localization

Tissue SpecificbrainCell SpecificAstrocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (7)

Biological Process (3)

Reactome (8)

Mediation Categories (2)

Clinical-translation mediationReceptor-signaling mediation

Relations & Evidence31

Enzyme-Mediated Modification (8)

8 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PEBP1	PRKCA	P17252	S	153	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEAphosphoELMPhosphoSitePhosphoSite_ProtMapper	HPRD:14654844 HPRD:12551925 HPRD:20068231 KEA:12551925 phosphoELM:14654844 KEA:14654844 HPRD:20166139
PEBP1	PRKCD	Q05655	S	153	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:14654844 SIGNOR:14654844 HPRD:12551925 HPRD:20068231 KEA:12551925 ProtMapper:14654844 phosphoELM:14654844 KEA:14654844 HPRD:20166139
PEBP1	PRKCD	Q05655	T	51	phosphorylation	PhosphoNetworks
PEBP1	PRKCG	P05129	S	153	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	HPRD:14654844 ProtMapper:12551925 SIGNOR:12551925 HPRD:12551925 HPRD:20068231 KEA:12551925 KEA:14654844 HPRD:20166139
PEBP1	PRKCB	P05771	S	153	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPHPRDKEA	HPRD:14654844 HPRD:12551925 HPRD:20068231 KEA:12551925 KEA:14654844 HPRD:20166139
PEBP1	PRKCZ	Q05513	S	153	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPProtMapperHPRDKEA	HPRD:14654844 ProtMapper:12551925 HPRD:12551925 HPRD:20068231 KEA:12551925 ProtMapper:10891480 KEA:14654844 HPRD:20166139
PEBP1	TBK1	Q9UHD2	S	109	phosphorylation	Sparser_ProtMapperProtMapperRLIMS-P_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:27753621
PEBP1	CDK5	Q00535	T	42	phosphorylation	PhosphoSiteSparser_ProtMapperProtMapper	ProtMapper:30181452 ProtMapper:25104559

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database
intracellular	intracellular	LOCATE
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Regulatory Interaction Network (9)

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PEBP1	P30086	RAF1	P04049	Yes	Yes	Yes	NetPathSIGNORProtMapperREACH_ProtMapperHPRDHINTAlzPathwaySignaLink3BioGRIDIntActInnateDBCancerCellMapSPIKE_LCLit-BM-17SPIKE	CancerCellMap:10757792 ProtMapper:23416466 HINT:15886202 Lit-BM-17:10757792 IntAct:21831839 BioGRID:15886202 HPRD:17097642 InnateDB:11585904 HINT:10757792 SPIKE:10490027 SignaLink3:17097642 SignaLink3:10757792 Lit-BM-17:17097642 IntAct:17097642 HINT:17097642 SPIKE_LC:10757792 SIGNOR:10490027 SignaLink3:10490027 SignaLink3:23331499 Lit-BM-17:14654844 SPIKE_LC:10490027 SPIKE_LC:17097642 Lit-BM-17:21831839 AlzPathway:17706925 HINT:21831839 NetPath:10757792 SPIKE:10757792 SPIKE_LC:16189514
PEBP1	P30086	M3K7	O43318	Yes	Yes		InnateDBHPRDSignaLink3InnateDB_SignaLink3	InnateDB:11585904 SignaLink3:23331499 SignaLink3:11585904 SignaLink3:23180781 HPRD:11585904
PEBP1	P30086	BRAF	P15056	Yes	Yes		SignaLink3	SignaLink3:23331499 SignaLink3:10490027
PEBP1	P30086	MP2K1	Q02750	Yes	Yes		CancerCellMapNetPathSignaLink3HPRD	CancerCellMap:10757792 NetPath:10757792 SignaLink3:10490027 SignaLink3:23331499 SignaLink3:10757792 HPRD:10757792
PEBP1	P30086	M4K4	O95819	Yes	Yes		SignaLink3	SignaLink3:23331499 SignaLink3:11585904
KPCD	Q05655	PEBP1	P30086	Yes	Yes		PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	HPRD:14654844 ProtMapper:12551925 SIGNOR:14654844 HPRD:12551925 ProtMapper:20166139 KEA:12551925 ProtMapper:20068231 HPRD-phos:20068231 HPRD-phos:14654844 HPRD-phos:12551925 phosphoELM:14654844 HPRD-phos:20166139 KEA:14654844 ProtMapper:14654844
CDK5	Q00535	PEBP1	P30086	Yes		Yes	Sparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:30181452 PhosphoSite:25104559 ProtMapper:25104559 SIGNOR:25104559
KPCG	P05129	PEBP1	P30086	Yes	Yes		WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDCui2007PhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	HPRD:14654844 ProtMapper:12551925 SIGNOR:12551925 HPRD:12551925 ProtMapper:20166139 KEA:12551925 ProtMapper:20068231 HPRD-phos:20068231 HPRD-phos:14654844 HPRD-phos:12551925 HPRD-phos:20166139 KEA:14654844 ProtMapper:14654844
KPCA	P17252	PEBP1	P30086	Yes	Yes		HPRD_MIMPProtMapperHINTPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMPhosphoSiteHPRD-phos	HPRD:14654844 HINT:12551925 PhosphoSite:17170028 ProtMapper:12551925 PhosphoSite:19096942 HPRD:12551925 HINT:14654844 ProtMapper:20166139 KEA:12551925 ProtMapper:20068231 HPRD-phos:20068231 PhosphoSite:14654844 HPRD-phos:14654844 HPRD-phos:12551925 phosphoELM:14654844 HPRD-phos:20166139 KEA:14654844 ProtMapper:14654844

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster259	DHRS2 DHRS4 DHRS4L2 PEBP1	P30086 Q13268 Q6PKH6 Q9BTZ2	1:1:1:1	Compleat	Compleat:HC1736	22036573
HT_DM_Cluster436	PEBP1 PEBP4 TBCB	P30086 Q96S96 Q99426	1:1:1	Compleat	Compleat:HC1539	22036573
HT_SC_Cluster342	CPVL CTSA PEBP1	P10619 P30086 Q9H3G5	1:1:1	Compleat	Compleat:HC303
	KIZ PEBP1 SCLT1 TDRD6	O60522 P30086 Q2M2Z5 Q96NL6	0:0:0:0	hu.MAP2
	DHPS EIF5A EIF5A2 PEBP1 RPL9P8 UBC	P0CG48 P30086 P32969 P49366 P63241 Q9GZV4	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7039
	PEBP1	P30086	2	PDB	PDB:1bd9PDB:1beh
	GLE1 NUP107 NUP133 NUP153 NUP214 NUP58 NUP85 NUP98 NXF1 PEBP1 SEC13 SEH1L XPO5	P30086 P35658 P49790 P52948 P55735 P57740 Q53GS7 Q8WUM0 Q96EE3 Q9BVL2 Q9BW27 Q9HAV4 Q9UBU9	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6378
	NAA40 PEBP1 TSN TSNAX	P30086 Q15631 Q86UY6 Q99598	1:1:1:1	NetworkBlastCompleat	Compleat:HC8740

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryWestern blotting	1	37886648

Sequence, Structure & Domains

Sequences

Length

187

Mass

21,057

Sequence

MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSGK

3D Structural Models

Turn

8..12; 43..46; 144..146; 184..186

Helix

5..7; 14..16; 97..99; 151..157; 177..183

Beta Strand

22..24; 26..28; 32..34; 51..54; 62..71; 76..78; 84..93; 100..104; 118..129; 140..142; 164..171

3D Structure

NMR spectroscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Region

93..134; Interaction with RAF1

Protein Families

Phosphatidylethanolamine-binding protein family

Sequence Similarities

Belongs to the phosphatidylethanolamine-binding protein family.

Clinical Relevance

Drugs (2)

THERAPEUTIC ANDROSTANOLONE FLUTAMIDE

Antibody (5)

HPA008819 CAB009906 CAB013493 HPA063904 CAB080063

Interaction Protein (2)

ENSG00000112079ENSG00000132155

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications36

PMID	Title	Related sentences
37563857	Comprehensive characterization of human brain-derived extracellular vesicles using multiple isolation methods: Implications for diagnostic and therapeutic applications.	No related sentences available
37670049	Proteomic and functional characterisation of extracellular vesicles from collagen VI deficient human fibroblasts reveals a role in cell motility.	No related sentences available
37926756	Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.	No related sentences available
38014595	Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia.	No related sentences available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No related sentences available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No related sentences available
38607062	Enrichment, Characterization, and Proteomic Profiling of Small Extracellular Vesicles Derived from Human Limbal Mesenchymal Stromal Cells and Melanocytes.	No related sentences available
38891077	Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease.	No related sentences available
39001700	Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles.	No related sentences available
39207047	The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis.	No related sentences available

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