Protein detail
ACHA5
Neuronal acetylcholine receptor subunit alpha-5
Entry name ACHA5 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count 4 | Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Neuronal acetylcholine receptor subunit alpha-5
Protein Class
FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
255..275; Helical; 282..302; Helical; 317..337; Helical; 430..451; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Cholinergic receptor nicotinic alpha 5 subunit
Chromosome
15
Position
78565520-78595269
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificcervixCell SpecificCardiomyocytesSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-181431 acetylcholine binding and downstream events
- R-hsa-629597 highly calcium permeable nicotinic acetylcholine receptors
- R-hsa-629594 highly calcium permeable postsynaptic nicotinic acetylcholine receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-622323 presynaptic nicotinic acetylcholine receptors
- R-hsa-112315 transmission across chemical synapses
Canonical Pathways
- M247 Pid insulin glucose pathway
- M91 Pid tcptp pathway
- M16 Pid insulin pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | No | No |
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| gaba_ach | receptor | Almen2009 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
1 record.
Isolation & Detection Technology
0 records.
Sequence, Structure & Domains
Sequences
Length
468
Mass
53,054
Sequence
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
3D Structural Models
Domain & Motif Annotations
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Acetylcholine receptor (TC 1.A.9.1) subfamily
- Alpha-5/CHRNA5 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Antibody
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell