Protein detail
ACHA5
Neuronal acetylcholine receptor subunit alpha-5
Entry name ACHA5 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 4 | Protein classification FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Neuronal acetylcholine receptor subunit alpha-5
Protein Class (3)
FDA approved drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Transmembrane
255..275; Helical; 282..302; Helical; 317..337; Helical; 430..451; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Description
Cholinergic receptor nicotinic alpha 5 subunit
Chromosome
15
Position
78565520-78595269
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificcervixCell SpecificCardiomyocytesSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function (2)
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function (4)
Biological Process (3)
Reactome (7)
- R-hsa-181431 acetylcholine binding and downstream events
- R-hsa-629597 highly calcium permeable nicotinic acetylcholine receptors
- R-hsa-629594 highly calcium permeable postsynaptic nicotinic acetylcholine receptors
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-622323 presynaptic nicotinic acetylcholine receptors
- R-hsa-112315 transmission across chemical synapses
Canonical Pathways (3)
- M247 Pid insulin glucose pathway
- M91 Pid tcptp pathway
- M16 Pid insulin pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence35
Ligand-Receptor Signaling (34)
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| channels | transporter | Surfaceome | Yes | ||||
| ion_channel | ion_channel | DGIdb | Yes | ||||
| ion_channel | ion_channel | Almen2009 | Yes | ||||
| ligand_gated | ion_channel | Almen2009 | Yes | ||||
| ligand_gated | ion_channel | Surfaceome | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| ion_channel | ion_channel | OmniPath | Yes | ||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword |
Protein Complex Composition (1)
1 record.
Sequence, Structure & Domains
Sequences
Length
468
Mass
53,054
Sequence
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
Domain & Motif Annotations
Protein Families (3)
- Ligand-gated ion channel (TC 1.A.9) family
- Acetylcholine receptor (TC 1.A.9.1) subfamily
- Alpha-5/CHRNA5 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Antibody
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 37922300 | Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women. | No related sentences available |
| 40784529 | Serum-derived exosome proteomics unveils the distinct and adjustable nature of the dampness constitution in traditional Chinese medicine. | No related sentences available |