Protein detail
GBRA5
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5)
Protein symbol GBRA5 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5)
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Transmembrane
261..281; Helical; 287..308; Helical; 319..340; Helical; 428..448; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifickidneyCell SpecificProximal tubule cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Epilepsy
- Transporters:Transporter channels and pores
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
- GO:0005654 nucleoplasm
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0032590 dendrite membrane
- GO:0032809 neuronal cell body membrane
- GO:0034707 chloride channel complex
- GO:0042734 presynaptic membrane
- GO:0043005 neuron projection
- GO:0045202 synapse
- GO:0098794 postsynapse
- GO:0098982 GABA-ergic synapse
- GO:0099634 postsynaptic specialization membrane
- GO:1902495 transmembrane transporter complex
- GO:1902711 GABA-A receptor complex
Molecular Function
- GO:0004890 GABA-A receptor activity
- GO:0005254 chloride channel activity
- GO:0008503 benzodiazepine receptor activity
- GO:0022851 GABA-gated chloride ion channel activity
- GO:0038023 signaling receptor activity
- GO:0050811 GABA receptor binding
- GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
KEGG
Reactome
Canonical Pathways
- M47 Pid integrin cs pathway
- M67 Pid arf6 trafficking pathway
- M18 Pid integrin1 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | No | No |
| gaba_ach | receptor | Almen2009 | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| cys_loop | transporter | Surfaceome | No | Yes | No | No | No |
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Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PCD19 | Q8TAB3 | GBRA5 | P31644 | Yes | Yes | No | SIGNOR | SIGNOR:29360992 |
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GABA-A (a5-b1-g2) receptor | GABRA5GABRB1GABRG2 | P18505P18507P31644 | 2:1:2 | SIGNORComplexPortal | SIGNOR:SIGNOR-C335intact:EBI-48439929 | 3060789914755292282328651879087437892178 |
| GABA-A receptoralpha5-beta2-gamma2 | GABRA5GABRB2GABRG2 | P18507P31644P47870 | 1:2:2 | ComplexPortal | intact:EBI-48423908 | 30607899282328651475529237892178 |
| GABRA5GABRG2 | P18507P31644 | 1:4 | PDB | PDB:8bhg | ||
| GABRA5 | P31644 | 5 | PDB | PDB:5ojmPDB:8bgiPDB:8bhoPDB:8bhsPDB:8bhbPDB:5o8fPDB:8bejPDB:8bhqPDB:8bhkPDB:8bhiPDB:8bhrPDB:8bhaPDB:8bhm |
Sequence, Structure & Domains
Sequences
Length
462
Mass
52,146
Sequence
MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK
3D Structural Models
Turn
66..70; 89..92; 125..127; 178..181; 198..200; 217..219; 345..347
Helix
46..57; 107..109; 122..124; 258..263; 265..276; 277..280; 286..309; 319..344; 421..449
Beta Strand
73..88; 93..105; 114..120; 133..135; 138..143; 146..148; 150..156; 160..172; 184..187; 190..195; 201..205; 208..210; 212..215; 223..239; 242..255
3D Structure
Electron microscopy (11); X-ray crystallography (4)
Domain & Motif Annotations
Domain (CC)
GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.
Region
377..412; Disordered
Protein Families
- Ligand-gated ion channel (TC 1.A.9) family
- Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
- GABRA5 sub-subfamily
Sequence Similarities
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 2; Phase 1; Approved; Investigative
Drugs
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