Protein detail

GBRA5

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5)

Entry name GBRA5	UniProt ID P31644	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 4	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5) (GABAAR subunit alpha-5)

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

261..281; Helical; 287..308; Helical; 319..340; Helical; 428..448; Helical

Transmembrane Count

Ensembl

ENSG00000186297

Entrez Gene Symbol

GABRA5

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Tissue SpecifickidneyCell SpecificProximal tubule cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway8

Protein Function (5)

Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component (14)

Page 1 of 2

Molecular Function (8)

Biological Process (3)

KEGG (8)

Reactome (4)

Canonical Pathways (3)

M47 Pid integrin cs pathway
M67 Pid arf6 trafficking pathway
M18 Pid integrin1 pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence41

Ligand-Receptor Signaling (35)

35 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
channels	transporter	Surfaceome	No	Yes	No	No	No
ion_channel	ion_channel	DGIdb	No	Yes	No	No	No
ion_channel	ion_channel	Almen2009	No	Yes	No	No	No
ligand_gated	ion_channel	Almen2009	No	Yes	No	No	No
ligand_gated	ion_channel	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No

Page 2 of 4Previous Next

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PCD19	Q8TAB3	GBRA5	P31644	Yes	Yes	No	SIGNOR	SIGNOR:29360992

Protein Complex Composition (4)

4 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
GABA-A (a5-b1-g2) receptor	GABRA5 GABRB1 GABRG2	P18505 P18507 P31644	2:1:2	SIGNORComplexPortal	SIGNOR:SIGNOR-C335intact:EBI-48439929	30607899 14755292 28232865 18790874 37892178
GABA-A receptoralpha5-beta2-gamma2	GABRA5 GABRB2 GABRG2	P18507 P31644 P47870	1:2:2	ComplexPortal	intact:EBI-48423908	30607899 28232865 14755292 37892178
	GABRA5 GABRG2	P18507 P31644	1:4	PDB	PDB:8bhg
	GABRA5	P31644	5	PDB	PDB:5ojmPDB:8bgiPDB:8bhoPDB:8bhsPDB:8bhbPDB:5o8fPDB:8bejPDB:8bhqPDB:8bhkPDB:8bhiPDB:8bhrPDB:8bhaPDB:8bhm

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	4	38871114 38037300 38576002 39996590

Sequence, Structure & Domains11

Sequences

Length

462

Mass

52,146

Sequence

MDNGMFSGFIMIKNLLLFCISMNLSSHFGFSQMPTSSVKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKREVILNKSTNAFTTGKMSHPPNIPKEQTPAGTSNTTSVSVKPSEEKTSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK

3D Structural Models

Turn

66..70; 89..92; 125..127; 178..181; 198..200; 217..219; 345..347

Helix

46..57; 107..109; 122..124; 258..263; 265..276; 277..280; 286..309; 319..344; 421..449

Beta Strand

73..88; 93..105; 114..120; 133..135; 138..143; 146..148; 150..156; 160..172; 184..187; 190..195; 201..205; 208..210; 212..215; 223..239; 242..255

3D Structure

Electron microscopy (11); X-ray crystallography (4)

Domain & Motif Annotations

Domain (CC)

GABAARs subunits share a common topological structure: a peptide sequence made up of a long extracellular N-terminal, four transmembrane domains, intracellular or cytoplasmic domain located between the third and the fourth transmembrane domains.

Region

377..412; Disordered

Protein Families (3)

Ligand-gated ion channel (TC 1.A.9) family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
GABRA5 sub-subfamily

Sequence Similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.

Clinical Relevance3

Related Diseases (8)

Adaptive immunity immunodeficiency Alzheimer disease Autism spectrum disorder Indeterminate colitis Intentional self-harm Mild neurocognitive disorder Postoperative inflammation Sex development malformative disorder

Biomarker

Phase 2; Phase 1; Approved; Investigative

Drugs (88)

PAGOCLONE ISOFLURANE CLOBAZAM DIMDAZENIL FLUDIAZEPAM BUTALBITAL MIDAZOLAM HYDROCHLORIDE CLORAZEPATE BUTABARBITAL QUAZEPAM ESZOPICLONE CHLORDIAZEPOXIDE MEPHOBARBITAL MEPROBAMATE BUTOBARBITAL ADINAZOLAM HALAZEPAM HEXOBARBITAL NITRAZEPAM ALPRAZOLAM ACAMPROSATE CALCIUM METHOHEXITAL SODIUM TEMAZEPAM CHLORDIAZEPOXIDE HYDROCHLORIDE LORAZEPAM FLURAZEPAM FLUMAZENIL BUTABARBITAL SODIUM ETHCHLORVYNOL PENTOBARBITAL SODIUM THIAMYLAL SODIUM CENOBAMATE ZOPICLONE DIAZEPAM GANAXOLONE TALBUTAL TRIAZOLAM METHAQUALONE HYDROCHLORIDE BREXANOLONE ESTAZOLAM CINOLAZEPAM CLONAZEPAM REMIMAZOLAM HALOTHANE TETRAZEPAM CHEMBL:CHEMBL1077391 CLORAZEPATE DIPOTASSIUM THIOPENTAL PRAZEPAM METHYPRYLON TOPIRAMATE DESFLURANE CHLORMETHIAZOLE METHARBITAL GLUTETHIMIDE GABOXADOL ETIFOXINE FLUNITRAZEPAM PRIMIDONE SECOBARBITAL TRICLOFOS SODIUM OXAZEPAM LOREDIPLON OCINAPLON [3H]AZIETOMIDATE RESEQUINIL PHENOBARBITAL REMIMAZOLAM BESYLATE METHOXYFLURANE BASMISANIL ETOMIDATE CLOTIAZEPAM ABP-700 DARIGABAT ZURANOLONE BROMAZEPAM ADIPIPLON ENFLURANE SEVOFLURANE NULL FLURAZEPAM HYDROCHLORIDE METHAQUALONE CIPEPOFOL PROPOFOL SECOBARBITAL SODIUM THIOPENTAL SODIUM PADSEVONIL ALOGABAT

Supporting Publications1

PMID	Title	Abstract
37588411	Src family kinases engage differential pathways for encapsulation into extracellular vesicles.	No abstract available