Protein detail

CCKAR

Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)

Entry name CCKAR	UniProt ID P32238	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Cholecystokinin receptor type A (CCK-A receptor) (CCK-AR) (Cholecystokinin-1 receptor) (CCK1-R)

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

42..67; Helical; Name=1; 78..104; Helical; Name=2; 116..137; Helical; Name=3; 158..178; Helical; Name=4; 211..234; Helical; Name=5; 314..334; Helical; Name=6; 350..373; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000163394

Entrez Gene Symbol

CCKAR

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization5

Tissue Specificlymphoid tissueCell SpecificDifferentiating spermatogoniaBlood Cell SpecificT-regBlood Lineage SpecificT-cells

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

KEGG (5)

Reactome (5)

Canonical Pathways (3)

M274 Pid lymph angiogenesis pathway
M47 Pid integrin cs pathway
M165 Pid syndecan 4 pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence70

Ligand-Receptor Signaling (55)

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
endothelin_gastrin_releasing_peptide_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_peptide	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (14)

14 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CCKAR	P32238	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CCKAR	P32238	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
CCKN	P06307	CCKAR	P32238	Yes	Yes	No	iTALKSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbCellPhoneDBHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:10400673 HINT:35672283 Cellinker:11300760 connectomeDB2020:11300760 LRdb:10368033 Baccin2019:11300760 HINT:9603948 Cellinker:10595537 HPRD:11300760 HINT:11300760 HINT:10595537 CellTalkDB:10368033 LRdb:9006937 connectomeDB2020:9603948 Cellinker:10368033 HPRD:10595537 HINT:9006937 Baccin2019:10595537 HPRD:9603948 Cellinker:9603948 connectomeDB2020:9006937 Baccin2019:10368033 Baccin2019:10400673 LRdb:11300760 HINT:34086670 LRdb:9603948 connectomeDB2020:10368033 connectomeDB2020:10400673 Cellinker:9006937 LRdb:10595537 HINT:10400673 HPRD:9006937 Baccin2019:9603948 LRdb:10400673 Baccin2019:9006937 SIGNOR:10368033 HPRD:10400673 connectomeDB2020:10595537
CCKAR	P32238	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry；Western blotting；RNA Sequencing；Small RNA sequencing (Illumina HiSeq 2000)	1	40748658

Sequence, Structure & Domains11

Sequences

Length

428

Mass

47,841

Sequence

MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGIKFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSHMSASVPPQ

3D Structural Models

Turn

5..11; 371..373; 382..384

Helix

40..68; 70..72; 75..104; 111..144; 146..152; 155..172; 175..179; 188..190; 203..217; 219..242; 304..338; 340..347; 350..360; 362..370; 375..381

Beta Strand

13..15; 21..25; 180..186; 192..198

3D Structure

Electron microscopy (9); NMR spectroscopy (2); X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias

411..422; Polar residues

Region

248..272; Disordered; 394..428; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (8)

Binge eating disorder Bladder disorder Digestive system disease Dyspepsia Influenza Obesity Pancreatic cancer Pancreatic malfunction

Biomarker

Preclinical; Terminated; Discontinued in Phase 2; Phase 2

Drugs (19)

CCK-33 CCK-39 [3H]DEVAZEPIDE SR146131 DEXLOXIGLUMIDE SINCALIDE CE-326597 GW-5823 CERULETIDE PD-170292 [125I]DTYR-GLY-[(NLE28,31)CCK-26-33 PROGLUMIDE CERULETIDE DIETHYLAMINE GLAXO-11P JNJ-17156516 LINTITRIPT CCK-58 A-71378 JMV180

Supporting Publications1

PMID	Title	Abstract
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available