Protein detail

CD70

CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)

Entry name CD70	UniProt ID P32970	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

CD70 antigen (CD27 ligand) (CD27-L) (Tumor necrosis factor ligand superfamily member 7) (CD antigen CD70)

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Transmembrane

18..38; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000125726

Entrez Gene Symbol

CD70

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization5

Tissue Specificstomach 1Brain Regional SpecificcerebellumCell SpecificCholangiocytesSingle-Nuclei Brain Specificupper rhombic lip

Function & Pathway7

Protein Function (6)

Predicted intracellular proteins
Cancer-related genes:Mutated cancer genes
CD markers
Human disease related genes:Immune system diseases:Primary immunodeficiency
Cancer-related genes:Candidate cancer biomarkers
Disease related genes

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04060 Cytokine-cytokine receptor interaction

Reactome (3)

Mediation Categories (3)

Adhesion and uptake mediationImmune mediationReceptor-signaling mediation

Relations & Evidence52

Ligand-Receptor Signaling (50)

50 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	Yes	No	No
extracellular	extracellular	LOCATE	No	No	Yes	No	No
extracellular	extracellular	OmniPath	No	No	Yes	No	No
intracellular	intracellular	LOCATE	No	No	Yes	No	No
intracellular	intracellular	OmniPath	No	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	Baccin2019	Yes	No	Yes	No	No
tumor_necrosis_factor	cell_surface_ligand	HGNC	Yes	No	Yes	No	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	Yes	No	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	Yes	No	No

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Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CD70	P32970	CD27	P26842	Yes	Yes	No	iTALKKirouac2010Guide2Pharma_LRdbICELLNETSIGNORHINTCellPhoneDB_CellinkerUniProt_LRdbHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDWojtowicz2020Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbSPIKE	LRdb:7479974 HPRD:9862673 Cellinker:8186199 connectomeDB2020:8580829 HPRD:15723067 LRdb:8120384 HPMR:8120384 Baccin2019:8186199 SIGNOR:12324477 HPRD:8186199 Cellinker:8120384 ICELLNET:26697006 LRdb:15723067 connectomeDB2020:9767422 HPRD:9767422 Cellinker:8580829 LRdb:9767422 Baccin2019:8580829 SPIKE_LC:9862673 Baccin2019:9862673 SIGNOR:8120384 connectomeDB2020:9862673 SPIKE:9862673 Cellinker:9862673 Cellinker:7479974 LRdb:8580829 connectomeDB2020:8120384 Baccin2019:7479974 Cellinker:9767422 CellTalkDB:8120384 connectomeDB2020:8186199 HPRD:7479974 Baccin2019:9767422 Baccin2019:8120384 HINT:34419446 HINT:33961781 connectomeDB2020:15723067 ICELLNET:8120384 HPRD:8120384 LRdb:8186199 connectomeDB2020:7479974 BioGRID:21917027 HPRD:8580829 Cellinker:15723067 LRdb:9862673 Baccin2019:15723067

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	30865381

Sequence, Structure & Domains12

Sequences

Length

193

Mass

21,118

Sequence

MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P32970-1; Sequence=Displayed; Name=2; IsoId=P32970-2; Sequence=VSP_056416

Alternative Sequence

151..193; CTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP -> LFGFWNWGLKVKCFLRHLIWTAHCFIPLTQLVFMQALQSWRNHHCSHFTDEENRGVNR (in isoform 2)

3D Structural Models

Turn

79..81; 181..183

Helix

117..122

Beta Strand

57..65; 72..76; 85..88; 90..92; 95..97; 102..112; 127..132; 134..136; 141..146; 151..161; 166..174; 185..192

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

56..191; THD

Protein Families

Tumor necrosis factor family

Sequence Similarities

Belongs to the tumor necrosis factor family.

Clinical Relevance1

Drugs (13)

VORSETUZUMAB MAFODOTIN MDX-1411 VORSETZUMAB MAFODOTIN HYDROCHLOROTHIAZIDE ANTI-CD70 ANTIBODY-DRUG CONJUGATE MDX-1203 CHLOROTHIAZIDE VORSETUZUMAB NULL SGN-CD70A CUSATUZUMAB CYCLOTHIAZIDE METOLAZONE ANTI-CD27L ANTIBODY-DRUG CONJUGATE AMG 172

Supporting Publications2

PMID	Title	Abstract
26801919	Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis.	No abstract available
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.