Protein detail
CNR2
Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)
Protein symbol CNR2 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Cannabinoid receptor 2 (CB-2) (CB2) (hCB2) (CX5)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
34..59; Helical; Name=1; 72..92; Helical; Name=2; 105..129; Helical; Name=3; 150..172; Helical; Name=4; 189..214; Helical; Name=5; 247..267; Helical; Name=6; 280..301; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CB2
Gene Description
Cannabinoid receptor 2
Chromosome
1
Position
23870515-23913362
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CNR2 | GRK1 | Q15835 | S | 352 | phosphorylation | KEA | KEA:10400664 |
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CNR2 | P34972 | GNAI3 | P08754 | Yes | Yes | No | WangCui2007SIGNORCA1 | CA1:15082510SIGNOR:31160049 |
| CNR2 | P34972 | GNAO | P09471 | Yes | Yes | No | WangCui2007SIGNORCA1 | CA1:15082510SIGNOR:31160049 |
| CNR2 | P34972 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| MLKL | Q8NB16 | CNR2 | P34972 | Yes | No | Yes | SIGNOR | SIGNOR:10400664SIGNOR:36448459 |
| CNR2 | P34972 | GNAI1 | P63096 | Yes | Yes | No | HINTSIGNOR | SIGNOR:31160049HINT:32004460HINT:32004463HINT:36922494 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
360
Mass
39,681
Sequence
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
3D Structural Models
Turn
95..97; 224..226
Helix
22..24; 31..60; 62..65; 68..94; 103..136; 138..144; 147..165; 168..170; 188..219; 220..223; 230..233; 238..270; 275..284; 287..302; 304..318
Beta Strand
175..177; 181..183
3D Structure
Electron microscopy (7); NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
351..360; Basic and acidic residues
Region
327..360; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
FERRUGINENE C2-ARACHIDONOYLGLYCEROLSURINABANT[3H]WIN55212-2NONABINEPRS-211375AM10257WIN55212-2LENABASUMGW842166AM1241TM38837CP55940PHENYLACETYLRINVANILDRONABINOLSAD448S-777469N-[6-(4-CHLOROPHENYL)-7-(2,4-DICHLOROPHENYL)-2,2-DIMETHYL-3,4-DIHYDRO-2H-PYRANO[2,3-B]PYRIDINE-4-YL]-4,4,4-TRIFLUORO-3-HYDROXYBUTANAMIDE (DIASTEREOMERIC MIX)PEPCAN-12NABILONEJWH-018BAY-593074LY2828360JWH-133CANNABINORL-759,656TEDALINABAZD1940COMPOUND C2 [PMID: 29990428]SR144528AM2201SCH.336BMS-202VCE-004.3ONTERNABEZHU-210AM-630TARANABANTJWH015GW405833L-759,633OLORINABAM251HONOKIOLMDMB-FUBINACA[3H]HU-243AM7499VICASINABINANANDAMIDEIBIPINABANT
Antibody
Interaction Protein
ENSG00000161011
Interaction Count
1
Interaction Dataset
intact_biogrid