Protein detail

GPC1

Glypican-1 [Cleaved into: Secreted glypican-1]

Entry name
GPC1
UniProt ID
P35052
EVMP confidence score
0.50
Supporting publications (n)
4
Transmembrane count
Protein classification
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information6
Protein Names
Glypican-1 [Cleaved into: Secreted glypican-1]
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Ensembl
ENSG00000063660
Entrez Gene Symbol
GPC1
Supporting publications (n)
4
EVMP confidence score
0.50
Fluorescence & Localization2
GPC1 fluorescence
Cell SpecificNeutrophils
Function & Pathway8
Protein Function (2)
  • Disease related genes
  • Predicted intracellular proteins
Cellular Component (15)
Page 1 of 2
Molecular Function (4)
Biological Process (3)
KEGG (2)
Reactome (31)
Page 1 of 4
Canonical Pathways (3)
  • M83 Pid cdc42 reg pathway
  • M241 Pid rac1 reg pathway
  • M71 Pid ilk pathway
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence56

Ligand-Receptor Signaling (51)

51 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_surfacecell_surfaceconnectomeDB2020NoNoYesYesYes
glypicancell_surfaceHGNCNoNoYesYesYes
glypicancell_surfaceMatrisomeNoNoYesYesYes
cell_surfacecell_surfaceOmniPathNoNoYesYesYes
receptorreceptortalklrNoYesYesYesYes
receptorreceptorCellinkerNoYesYesYesYes
receptorreceptorconnectomeDB2020NoYesYesYesYes
receptorreceptoriTALKNoYesYesYesYes
growth_factorreceptoriTALKNoYesYesYesYes
receptorreceptorEMBRACENoYesYesYesYes
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Regulatory Interaction Network (2)

2 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
SLIT2O94813GPC1P35052YesYesNoFantom5_LRdbCellTalkDBHPMR_LRdbHPRD_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020HPRDHPRD_talklrCellinkerWangLRdbSTRING_talklrHPMR_talklrLRdb:10364234Cellinker:11375980HPRD:10364234Cellinker:29317497SIGNOR:10364234connectomeDB2020:11375980Cellinker:10364234LRdb:11375980connectomeDB2020:10364234CellTalkDB:11375980HPRD:11375980
SLIT1O75093GPC1P35052YesYesNoiTALKSIGNORHPMR_talklrHPRD_LRdbtalklrHPRDRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019CellinkerEMBRACEFantom5_LRdbCellTalkDBHPMR_CellinkerconnectomeDB2020SPIKE_LCLRdbBaccin2019:1036423410364230LRdb:10364234CellTalkDB:10364234HPRD:10364234SIGNOR:10364234SPIKE_LC:16713569connectomeDB2020:10364234Cellinker:10364234

Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
EGFLAMFGF1GPC1SDC4P05230P31431P35052Q63HQ20:0:0:0hu.MAP
GPC1P350524PDBPDB:4bwePDB:4ywtPDB:4ad7PDB:4acr

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationWestern blotting137922300
Sequence, Structure & Domains13

Sequences

Length
558
Mass
61,680
Sequence
MELRARGWWLLCAAAALVACARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35052-1; Sequence=Displayed; Name=2; IsoId=P35052-2; Sequence=VSP_055225, VSP_055226, VSP_055227
Alternative Sequence
1..72; Missing (in isoform 2); 295..359; DSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKR -> GEPPPARAAWNCLGECTTGGPGGRVVPSLELGPRDLIRDALTRARSGWCCRVEGPGCLLNVLSDV (in isoform 2); 360..558; Missing (in isoform 2)

3D Structural Models

Turn
41..43; 201..204
Helix
33..40; 46..48; 56..58; 71..130; 132..135; 138..153; 159..178; 187..192; 205..237; 244..254; 256..259; 269..279; 281..284; 287..300; 301..304; 313..315; 317..329; 332..335; 340..343; 374..388; 392..403; 434..436; 451..472
Beta Strand
60..62; 64..68; 180..182; 307..310; 418..422; 431..433; 440..442
3D Structure
X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias
355..370; Basic and acidic residues
Region
341..374; Disordered; 505..534; Disordered
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance3
Interaction Protein (2)
ENSG00000113070ENSG00000164076
Interaction Count
2
Interaction Dataset
biogrid_bioplex
Supporting Publications4
PMIDTitleAbstract
36963204The mechanisms underlying the enrichment and action of glypican-1-positive exosomes in colorectal cancer cells.No abstract available
37288703Dual Tumor Exosome Biomarker Co-recognitions Based Nanoliquid Biopsy for the Accurate Early Diagnosis of Pancreatic Cancer.This approach exhibits excellent specificity and ultrahigh sensitivity of detecting as low as 78 pg/mL pancreatic cancer exosome specific protein GPC1.
37368911Quantification of GPC1(+) Exosomes Based on MALDI-TOF MS In Situ Signal Amplification for Pancreatic Cancer Discrimination and Evaluation.No abstract available
38204202Extracellular Vesicular Analysis of Glypican 1 mRNA and Protein for Pancreatic Cancer Diagnosis and Prognosis.Utilizing an immune lipoplex nanoparticle (ILN) biochip assay, these findings demonstrate that glypican 1 (GPC1) mRNA expression in the exosomes-rich (Exo) EV subpopulation and GPC1 membrane protein (mProtein) expression in the microvesicles-rich (MV) EV subpopulation, particularly the tumor associated microvesicles (tMV), served as a viable biomarker for PDAC.