Protein detail
MYH9
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Protein symbol MYH9 | UniProt ID | EVMP score 0.88 |
Frequency 52 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNA17EPSTSFTNSMHANMHC-II-ANMMHCA
Gene Description
Myosin heavy chain 9
Chromosome
22
Position
36281280-36388010
Frequency
52
EVMP Score
0.88
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Disease related genes
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component
- GO:0001725 stress fiber
- GO:0001726 ruffle
- GO:0001772 immunological synapse
- GO:0001931 uropod
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005819 spindle
- GO:0005826 actomyosin contractile ring
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005903 brush border
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0008180 COP9 signalosome
- GO:0009898 cytoplasmic side of plasma membrane
- GO:0015629 actin cytoskeleton
- GO:0016020 membrane
- GO:0016460 myosin II complex
- GO:0016604 nuclear body
- GO:0031252 cell leading edge
- GO:0031594 neuromuscular junction
- GO:0032154 cleavage furrow
- GO:0032982 myosin filament
- GO:0032991 protein-containing complex
- GO:0042641 actomyosin
- GO:0060473 cortical granule
- GO:0070062 extracellular exosome
- GO:0097513 myosin II filament
Molecular Function
- GO:0000146 microfilament motor activity
- GO:0003723 RNA binding
- GO:0003774 cytoskeletal motor activity
- GO:0003779 actin binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005516 calmodulin binding
- GO:0005524 ATP binding
- GO:0019904 protein domain specific binding
- GO:0042802 identical protein binding
- GO:0042803 protein homodimerization activity
- GO:0043495 protein-membrane adaptor activity
- GO:0043531 ADP binding
- GO:0045296 cadherin binding
- GO:0051015 actin filament binding
Biological Process
KEGG
- hsa03273 Virion - Lassa virus and SFTS virus
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04530 Tight junction
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04814 Motor proteins
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05130 Pathogenic Escherichia coli infection
Reactome
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-9662834 cd163 mediating an anti inflammatory response
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-2682334 eph ephrin signaling
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-199991 membrane trafficking
- R-hsa-9675108 nervous system development
- R-hsa-9664407 parasite infection
- R-hsa-5625900 rho gtpases activate cit
- R-hsa-5627123 rho gtpases activate paks
- R-hsa-5625740 rho gtpases activate pkns
- R-hsa-5627117 rho gtpases activate rocks
- R-hsa-195258 rho gtpase effectors
- R-hsa-416572 sema4d induced cell migration and growth cone collapse
- R-hsa-400685 sema4d in semaphorin signaling
- R-hsa-373755 semaphorin interactions
- R-hsa-9709957 sensory perception
- R-hsa-9659379 sensory processing of sound
- R-hsa-9662361 sensory processing of sound by outer hair cells of the cochlea
- R-hsa-9700206 signaling by alk in cancer
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-1445148 translocation of slc2a4 glut4 to the plasma membrane
- R-hsa-5653656 vesicle mediated transport
Canonical Pathways
M277 Pid integrin a4b1 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
14 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| MYH9 | CSNK2B | P67870 | S | 1,916 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper | |
| MYH9 | PRKCG | P05129 | S | 1,916 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| MYH9 | PRKCD | Q05655 | S | 1,916 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| MYH9 | PRKCE | Q02156 | S | 1,916 | phosphorylation | MIMPphosphoELM_MIMPPhosphoSite_MIMP |
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Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
8 records.
Protein Complex Composition
9 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 37886648 |
Sequence, Structure & Domains
Sequences
Length
1,960
Mass
226,532
Sequence
MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35579-1; Sequence=Displayed; Name=2; IsoId=P35579-2; Sequence=VSP_035409, VSP_035410
Alternative Sequence
1..136; Missing (in isoform 2); 980..1421; Missing (in isoform 2)
3D Structural Models
Helix
1899..1903; 1904..1921
Beta Strand
1895..1897; 1922..1925
3D Structure
NMR spectroscopy (1); X-ray crystallography (4)
Domain & Motif Annotations
Compositional Bias
1035..1055; Basic and acidic residues; 1122..1137; Basic and acidic residues; 1948..1960; Basic and acidic residues
Coiled Coil
837..1926
Domain (CC)
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Domain (FT)
27..77; Myosin N-terminal SH3-like; 81..776; Myosin motor; 779..808; IQ
Region
2..838; Mediates interaction with LIMCH1; 654..676; Actin-binding; 1035..1057; Disordered; 1118..1137; Disordered; 1877..1960; Disordered
Protein Families
- TRAFAC class myosin-kinesin ATPase superfamily
- Myosin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Clinical Relevance
Disease Involvement
Alport syndromeCancer-related genesCataractDeafnessDisease variantNon-syndromic deafness
Interaction Protein
ENSG00000077549ENSG00000092841ENSG00000101335ENSG00000101608ENSG00000118680ENSG00000133895ENSG00000144381ENSG00000177885ENSG00000196154ENSG00000196465
Interaction Count
10
Interaction Dataset
biogrid_opencellintact_biogrid_opencellbiogrid_opencell_bioplexintact_biogrid