Protein detail
GLRX1
Glutaredoxin-1 (Thioltransferase-1) (TTase-1)
Entry name GLRX1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Metabolic proteinsPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Glutaredoxin-1 (Thioltransferase-1) (TTase-1)
Protein Class (3)
Metabolic proteinsPlasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
GRXGRX1
Gene Description
Glutaredoxin
Chromosome
5
Position
95751319-95822726
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization1
Cell SpecificEnterocytes
Function & Pathway7
Protein Function
Predicted intracellular proteins
Cellular Component (3)
Molecular Function (3)
Biological Process (3)
Reactome (2)
Canonical Pathways (3)
- M184 Pid ecadherin keratinocyte pathway
- M266 Pid ncadherin pathway
- M156 Pid ecadherin nascent aj pathway
Mediation Categories (2)
Fusion and delivery mediationMetabolism mediation
Relations & Evidence32
Ligand-Receptor Signaling (4)
4 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Protein Complex Composition (27)
27 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GLRXGOT2MX2REEP3UBC | P00505P0CG48P20592P35754Q6NUK4 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7509 | ||
| GLRXGOT2MX2REEP4UBC | P00505P0CG48P20592P35754Q9H6H4 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9508 | ||
| GLRXGOT2 | P00505P35754 | 0:0 | hu.MAP | |||
| ALDH8A1CFAP298GLRXKLK5 | P35754P57076Q9H2A2Q9Y337 | 0:0:0:0 | hu.MAP2 | |||
| GLRX2GPX4NAXD | P36969Q8IW45Q9NS18 | 0:0:0 | hu.MAP | |||
| GLRX5 | Q86SX6 | 4 | PDB | PDB:2wul | ||
| GLRX2 | Q9NS18 | 2 | PDB | PDB:2ht9 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains10
Sequences
Length
106
Mass
11,776
Sequence
MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ
3D Structural Models
Turn
48..51
Helix
2..9; 24..34; 54..65; 83..92; 94..101
Beta Strand
15..19; 42..47; 72..75; 78..82
3D Structure
NMR spectroscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
3..106; Glutaredoxin
Protein Families
Glutaredoxin family
Sequence Similarities
Belongs to the glutaredoxin family.
Clinical Relevance2
Drugs (2)
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |