Protein detail

GLRX1

Glutaredoxin-1 (Thioltransferase-1) (TTase-1)

Entry name GLRX1	UniProt ID P35754	EVMP confidence score 0.53
Supporting publications (n) 1	Transmembrane count	Protein classification Metabolic proteinsPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Glutaredoxin-1 (Thioltransferase-1) (TTase-1)

Protein Class (3)

Metabolic proteinsPlasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000173221

Entrez Gene Symbol

GLRX

Gene Synonym (2)

GRXGRX1

Gene Description

Glutaredoxin

Chromosome

Position

95751319-95822726

Supporting publications (n)

EVMP confidence score

0.53

Fluorescence & Localization

Cell SpecificEnterocytes

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

Reactome (2)

Canonical Pathways (3)

M184 Pid ecadherin keratinocyte pathway
M266 Pid ncadherin pathway
M156 Pid ecadherin nascent aj pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence32

Ligand-Receptor Signaling (4)

4 records.

Category	Parent	Database
intracellular	intracellular	ComPPI
intracellular	intracellular	GO_Intercell
intracellular	intracellular	UniProt_location
intracellular	intracellular	OmniPath

Protein Complex Composition (27)

27 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
GLRX3	O76003	2	PDB	PDB:3zywPDB:2yan
CIAPIN1 GLRX3 NADK SEC23A YWHAZ	O76003 O95544 P63104 Q15436 Q6FI81	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3813
BOLA2 CIAPIN1 GLRX3 NADK SEC23A	O76003 O95544 Q15436 Q6FI81 Q9H3K6	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7272
CIAPIN1 GLRX3 NDOR1	O76003 Q6FI81 Q9UHB4	0:0:0	hu.MAP2
BAG2 BAG3 DNAJC3 GLRX5 HSPA1B HSPA8 PAX8 PMPCA TRAP1	O95816 O95817 P0DMV9 P11142 Q06710 Q10713 Q12931 Q13217 Q86SX6	1:1:2:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3983
BAG2 BAG3 DNAJC3 GLRX5 HSPA1B PMPCA RAE1 RBM39 TRAP1	O95816 O95817 P0DMV9 P78406 Q10713 Q12931 Q13217 Q14498 Q86SX6	1:1:2:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6781
BAG2 BAG3 DNAJC3 GLRX5 HSPA1B PGAM5 PMPCA TRAP1 TSN	O95816 O95817 P0DMV9 Q10713 Q12931 Q13217 Q15631 Q86SX6 Q96HS1	1:1:2:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7780
ALDH1A1 BAG2 GLRX5 HSPA1B PMPCA TP53 TRAP1 TSN ZNF668	O95816 P00352 P04637 P0DMV9 Q10713 Q12931 Q15631 Q86SX6 Q96K58	1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6769
ALDH1A1 BAG2 GLRX5 HSPA1B PMPCA RAE1 TRAP1 TSN	O95816 P00352 P0DMV9 P78406 Q10713 Q12931 Q15631 Q86SX6	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8122
FABP3 GLRX GOT2 RIDA	P00505 P05413 P35754 P52758	0:0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

106

Mass

11,776

Sequence

MAQEFVNCKIQPGKVVVFIKPTCPYCRRAQEILSQLPIKQGLLEFVDITATNHTNEIQDYLQQLTGARTVPRVFIGKDCIGGCSDLVSLQQSGELLTRLKQIGALQ

3D Structural Models

Turn

48..51

Helix

2..9; 24..34; 54..65; 83..92; 94..101

Beta Strand

15..19; 42..47; 72..75; 78..82

3D Structure

NMR spectroscopy (2); X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

3..106; Glutaredoxin

Protein Families

Glutaredoxin family

Sequence Similarities

Belongs to the glutaredoxin family.

Clinical Relevance

Drugs (2)

BELATACEPT ABATACEPT

Antibody (3)

CAB008634 HPA046431 CAB069419

Supporting Publications1

PMID	Title	Related sentences
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No related sentences available