Protein detail

MOT8

Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)

Entry name
MOT8
UniProt ID
P36021
EVMP confidence score
0.40
Supporting publications (n)
4
Transmembrane count
12
Protein classification
Basic Information
Protein Names
Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
  • Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Transmembrane
97..117; Helical; Name=1; 144..164; Helical; Name=2; 172..192; Helical; Name=3; 201..221; Helical; Name=4; 230..250; Helical; Name=5; 259..279; Helical; Name=6; 323..343; Helical; Name=7; 357..377; Helical; Name=8; 387..407; Helical; Name=9; 410..430; Helical; Name=10; 448..468; Helical; Name=11; 478..498; Helical; Name=12
Transmembrane Count
12
Ensembl
ENSG00000147100
Entrez Gene Symbol
SLC16A2
Supporting publications (n)
4
EVMP confidence score
0.40
Function & Pathway
Protein Function (4)
  • Transporters:Electrochemical Potential-driven transporters
  • Disease related genes
  • Potential drug targets
  • Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
KEGG (2)
Reactome (4)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence18

Ligand-Receptor Signaling (15)

15 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
extracellularextracellularDGIdb
extracellularextracellularOmniPath
intracellularintracellularLOCATE
intracellularintracellularOmniPath
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
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Protein Complex Composition (2)

2 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
SLC16A2P360212PDBPDB:8zkoPDB:8zkn
SLC16A2TEX29P36021Q8N6K00:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion ChromatographyMass spectrometry6382071063732247536497184401894974106825333309826
Sequence, Structure & Domains

Sequences

Length
539
Mass
59,511
Sequence
MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLPGSPNPEEPI

3D Structural Models

3D Structure
Electron microscopy (6)

Domain & Motif Annotations

Compositional Bias
31..41; Acidic residues; 42..64; Pro residues; 508..518; Basic and acidic residues
Region
1..92; Disordered; 508..539; Disordered
Protein Families (2)
  • Major facilitator superfamily
  • Monocarboxylate porter (TC 2.A.1.13) family
Sequence Similarities
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Clinical Relevance
Interaction Protein
ENSG00000167930
Interaction Count
1
Interaction Dataset
intact_biogrid_opencell
Supporting Publications4
PMIDTitleRelated sentences
26196085Identification of prostate cancer biomarkers in urinary exosomes.No related sentences available
28054239The Protein Content of Extracellular Vesicles Derived from Expanded Human Umbilical Cord Blood-Derived CD133+ and Human Bone Marrow-Derived Mesenchymal Stem Cells Partially Explains Why both Sources are Advantageous for Regenerative Medicine.No related sentences available
37686366Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available