Protein detail

MOT8

Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)

Protein symbol MOT8	UniProt ID P36021	EVMP score 0.50
Frequency 4	Transmembrane count 12	Protein classification

Basic Information

Protein Names

Monocarboxylate transporter 8 (MCT 8) (Monocarboxylate transporter 7) (MCT 7) (Solute carrier family 16 member 2) (X-linked PEST-containing transporter)

Protein Function

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases

Transmembrane

97..117; Helical; Name=1; 144..164; Helical; Name=2; 172..192; Helical; Name=3; 201..221; Helical; Name=4; 230..250; Helical; Name=5; 259..279; Helical; Name=6; 323..343; Helical; Name=7; 357..377; Helical; Name=8; 387..407; Helical; Name=9; 410..430; Helical; Name=10; 448..468; Helical; Name=11; 478..498; Helical; Name=12

Transmembrane Count

Ensembl

ENSG00000147100

Entrez Gene Symbol

SLC16A2

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Endocrine and metabolic diseases:Thyroid gland diseases

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	SLC16A2	P36021	2	PDB	PDB:8zkoPDB:8zkn
	SLC16A2 TEX29	P36021 Q8N6K0	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	6	38207106 37322475 36497184 40189497 41068253 33309826

Sequence, Structure & Domains

Sequences

Length

539

Mass

59,511

Sequence

MALQSQASEEAKGPWQEADQEQQEPVGSPEPESEPEPEPEPEPVPVPPPEPQPEPQPLPDPAPLPELEFESERVHEPEPTPTVETRGTARGFQPPEGGFGWVVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIRMLGDKIKLAQTFQVLSTFMFVLMLLSLTYRPLLPSSQDTPSKRGVRTLHQRFLAQLRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEEEFSEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLAPDPDPNGELLPGSPNPEEPI

3D Structural Models

3D Structure

Electron microscopy (6)

Domain & Motif Annotations

Compositional Bias

31..41; Acidic residues; 42..64; Pro residues; 508..518; Basic and acidic residues

Region

1..92; Disordered; 508..539; Disordered

Protein Families

Major facilitator superfamily
Monocarboxylate porter (TC 2.A.1.13) family

Sequence Similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Clinical Relevance

Interaction Protein

ENSG00000167930

Interaction Count

Interaction Dataset

intact_biogrid_opencell