Protein detail
CXG1
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)
Entry name CXG1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 4 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
23..45; Helical; 76..95; Helical; 176..198; Helical; 229..248; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function (2)
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component (8)
Molecular Function (5)
- GO:0005216 monoatomic ion channel activity
- GO:0005243 gap junction channel activity
- GO:0005515 protein binding
- GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
- GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process (3)
Reactome (6)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence33
Ligand-Receptor Signaling (30)
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath | |||||
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | ||||
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | ||||
| ion_channel | ion_channel | DGIdb | Yes | ||||
| transporter | transporter | OmniPath | Yes | ||||
| ion_channel | ion_channel | OmniPath | Yes |
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Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
396
Mass
45,470
Sequence
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
147..156; Basic and acidic residues; 376..387; Polar residues
Region
145..165; Disordered; 353..396; Disordered
Protein Families (2)
- Connexin family
- Gamma-type subfamily
Sequence Similarities
Belongs to the connexin family. Gamma-type subfamily.
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 36064647 | Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells. | No related sentences available |