Protein detail
CXG1
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)
Protein symbol CXG1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 4 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Transmembrane
23..45; Helical; 76..95; Helical; 176..198; Helical; 229..248; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neuronsBlood Cell Specificplasmacytoid DCBlood Lineage Specificdendritic cells
Function & Pathway
Protein Function
- Transporters:Transporter channels and pores
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0005216 monoatomic ion channel activity
- GO:0005243 gap junction channel activity
- GO:0005515 protein binding
- GO:0086020 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling
- GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
30 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| gap_junction | gap_junction | GO_Intercell | Yes | Yes | No | No | No |
| gap_junction | gap_junction | Ramilowski_location | Yes | Yes | No | No | No |
| gap_junction | gap_junction | UniProt_location | Yes | Yes | No | No | No |
| gap_junction | gap_junction | Almen2009 | Yes | Yes | No | No | No |
| gap_junction | gap_junction | HGNC | Yes | Yes | No | No | No |
| gap_junction | gap_junction | UniProt_keyword | Yes | Yes | No | No | No |
| gap_junction | gap_junction | OmniPath | Yes | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
396
Mass
45,470
Sequence
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
147..156; Basic and acidic residues; 376..387; Polar residues
Region
145..165; Disordered; 353..396; Disordered
Protein Families
- Connexin family
- Gamma-type subfamily
Sequence Similarities
Belongs to the connexin family. Gamma-type subfamily.