Protein detail

TGFR2

TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

Entry name
TGFR2
UniProt ID
P37173
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Predicted secreted proteins
  • Kinases:TKL Ser/Thr protein kinases
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Transmembrane
167..187; Helical
Transmembrane Count
1
Ensembl
ENSG00000163513
Entrez Gene Symbol
TGFBR2
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Predicted secreted proteins
  • Kinases:TKL Ser/Thr protein kinases
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
M141 Pid pi3kci pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
TGFBR2SRCP12931Y284phosphorylationSparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:16859511SIGNOR:19114990ProtMapper:26357075ProtMapper:17440088ProtMapper:21532881ProtMapper:19114990
TGFBR2SRCP12931Y309phosphorylationMIMPPhosphoSite_MIMP
TGFBR2CSNK1DP48730S213phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling

71 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellPhoneDBNoYesYesYesNo
receptorreceptorGO_IntercellNoYesYesYesNo
receptorreceptorHPMRNoYesYesYesNo
receptorreceptorICELLNETNoYesYesYesNo
receptorreceptorCellChatDBNoYesYesYesNo
receptorreceptorCellTalkDBNoYesYesYesNo
receptorreceptorSurfaceomeNoYesYesYesNo
receptorreceptorRamilowski2015NoYesYesYesNo
receptorreceptorGuide2PharmaNoYesYesYesNo
receptorreceptorLRdbNoYesYesYesNo
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Regulatory Interaction Network

20 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
EIF3IQ13347TGFR2P37173YesYesNoNetPathSIGNORHPRDCui2007CancerCellMapSPIKE_LCSPIKECancerCellMap:7566156SPIKE_LC:7566156HPRD:7566156SIGNOR:9774674NetPath:7566156HPRD:11781097SPIKE:7566156
TGFR2P37173TGFR1P36897YesYesNoSPIKEHPRD_MIMPSIGNORProtMapperdbPTMHINTPhosphoSite_KEASignaLink3InnateDBDIPLit-BM-17HPRDCui2007WangPhosphoSite_ProtMapperPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEABioGRIDHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSiteNetPathSPIKE_LCHPRD-phosNetPath:11323414SIGNOR:26194464HPRD-phos:8576253HPRD:7890683InnateDB:18243111Lit-BM-17:11483955Lit-BM-17:25825445SignaLink3:16446785HINT:20207738PhosphoSite:7774578NetPath:7566156SignaLink3:8576253SignaLink3:21791611ProtMapper:7774578NetPath:15221015Lit-BM-17:7878020NetPath:11387212BioGRID:25825445SIGNOR:8576253Lit-BM-17:10026191DIP:23868260HINT:10026191Lit-BM-17:21791611Lit-BM-17:19758997NetPath:9463378SignaLink3:18988627DIP:7878020KEA:8576253NetPath:11278251SPIKE_LC:10716993HINT:7890683Lit-BM-17:7890683DIP:10026191NetPath:11124802SPIKE_LC:7878020dbPTM:7774578HINT:11483955SignaLink3:7890683SPIKE:7878020SignaLink3:23331499Lit-BM-17:19556242HINT:33961781SIGNOR:7774578HPRD:8576253SignaLink3:21071413HINT:7878020HINT:23868260HINT:14612425NetPath:8047140SignaLink3:11102446ProtMapper:22802914ProtMapper:11707292ProtMapper:8576253HINT:18243111SPIKE:10716993
TGFR2P37173PAR6AQ9NPB6YesYesNoSparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperSPIKESPIKE_LCProtMapper:25756394SIGNOR:23249950ProtMapper:24231509ProtMapper:15761148ProtMapper:19114990SIGNOR:15761148SPIKE:15761148ProtMapper:23249950SPIKE_LC:15761148
DAXXQ9UER7TGFR2P37173YesYesNoWangNetPathSIGNORHPRDSignaLink3CancerCellMapSPIKE_LCLit-BM-17SPIKECancerCellMap:11483955HPRD:11483955SPIKE:11483955NetPath:11483955SIGNOR:11483955SPIKE_LC:17145710Lit-BM-17:11483955SPIKE:17145710SPIKE_LC:11483955SignaLink3:11483955SignaLink3:23331499
TGFB3P10600TGFR2P37173YesYesNoiTALKSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPRD_LRdbInnateDB_SignaLink3talklrscConnectHPRDCui2007IntActDLRP_talklrCancerCellMapRamilowski2015HPMR_LRdbHPRD_talklrBioGRIDSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKELRdb:12729750LRdb:8106553SignaLink3:11157754HPRD:8106553IntAct:11850637SPIKE_LC:17145710InnateDB:18243111HINT:21423151SignaLink3:11382746CancerCellMap:11382746SPIKE:17145710SignaLink3:11850637SignaLink3:16446785Lit-BM-17:11157754Lit-BM-17:11850637Guide2Pharma:29170498SignaLink3:9872992Lit-BM-17:12729750CancerCellMap:12729750IntAct:21423151connectomeDB2020:8106553Lit-BM-17:7878020connectomeDB2020:11382746connectomeDB2020:12729750HINT:11850637SIGNOR:11157754CellTalkDB:11850637SPIKE_LC:11382746HINT:7852346DIP:7878020SignaLink3:18988627scConnect:29170498SignaLink3:15017149Lit-BM-17:21423151NetPath:11382746BioGRID:11850637SPIKE:11382746HPRD:11850637LRdb:11382746Lit-BM-17:9872992HPRD:12729750SignaLink3:23331499SignaLink3:18243111InnateDB:15017149HPRD:11382746SignaLink3:21071413HINT:7878020CancerCellMap:11850637BioGRID:12729750SignaLink3:8106553HINT:12729750SignaLink3:23180781connectomeDB2020:11850637LRdb:11850637SignaLink3:12729750HINT:18243111
TGFB2P61812TGFR2P37173YesYesNoiTALKSIGNORHINTSignaLink3UniProt_LRdbHPMR_talklrHPMRHPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019DLRP_talklrRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKELRdb:8106553SignaLink3:11157754HPRD:8106553SPIKE:12729750CellTalkDB:11157754SignaLink3:16446785SPIKE_LC:12729750connectomeDB2020:8106553connectomeDB2020:11157754Baccin2019:12809600LRdb:11157754SIGNOR:11157754HINT:28228478connectomeDB2020:12809600HPRD:11157754LRdb:12809600SignaLink3:23331499SignaLink3:21071413Baccin2019:11157754HPMR:12809600Baccin2019:8106553HINT:28192420SIGNOR:1310899NetPath:12729750
TGFR2P37173P85AP27986YesYesNoWangNetPathPhosphoPointSIGNORHPRDSPIKE_LCSPIKEHPRD:9435577SIGNOR:9435577SIGNOR:19114990SPIKE:9435577NetPath:9435577SPIKE_LC:9435577
TGFR2P37173ZFYV9O95405YesYesNoWangNetPathPhosphoPointSIGNORHPRDCui2007CancerCellMapSPIKE_LCSPIKENetPath:9865696CancerCellMap:9865696HPRD:9865696SIGNOR:9865696SPIKE_LC:9865696SPIKE:9865696
DAB2P98082TGFR2P37173YesYesNoWangNetPathHPRDCui2007SignaLink3CancerCellMapSPIKE_LCSPIKESPIKE:11387212CancerCellMap:11387212HPRD:11387212NetPath:11387212SPIKE_LC:16713569SignaLink3:23331499SPIKE_LC:11387212SignaLink3:11387212SPIKE:16713569
TGFR2P37173VPS39Q96JC1YesYesNoSPIKENetPathSPIKE_LCSIGNORNetPath:12941698SPIKE_LC:12941698SPIKE:12941698SIGNOR:12941698
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Protein Complex Composition

6 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACVR1B_TGFbR2ACVR1BTGFBR2P36896P371730:0CellinkerCellChatDB
ACVR1C_TGFbR2ACVR1CTGFBR2P37173Q8NER50:0CellinkerCellChatDB
TGF-beta receptor II-TGF-beta3 complexTGFB3TGFBR2P10600P371731:1CompleatCORUMPDBCORUM:3025Compleat:HC656PDB:1ktz1628957611850637
TGF-beta-receptor type II homodimer complexTGFBR2P371730CORUMCORUM:30417521335
TGFbeta_receptor2ACVR1TGFBR2P37173Q047711:1CellPhoneDBCellPhoneDB:TGFbeta_receptor2
TGFB2TGFBR2P37173P618121:1PDBPDB:5tx4PDB:5ty4

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingFlow cytometry23064661638321535
Sequence, Structure & Domains

Sequences

Length
567
Mass
64,568
Sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=betaR-II; IsoId=P37173-1; Sequence=Displayed; Name=2; Synonyms=betaR-IIB; IsoId=P37173-2; Sequence=VSP_012157; Name=3; Synonyms=TbetaRII-SE; IsoId=P37173-3; Sequence=VSP_061513, VSP_061514
Alternative Sequence
31..32; SV -> SDVEMEAQKDEIICPSCNRTAHPLRHI (in isoform 2); 68..80; MSNCSITSICEKP -> FSKVHYEGKKKAW (in isoform 3); 81..567; Missing (in isoform 3)

3D Structural Models

Turn
114..117; 297..299; 473..477; 492..494
Helix
143..145; 151..153; 281..283; 284..294; 333..339; 344..362; 382..384; 410..413; 422..424; 427..430; 440..459; 462..464; 484..491; 502..506; 508..520; 525..527; 531..539
Beta Strand
40..45; 50..52; 55..58; 65..68; 74..76; 78..81; 83..90; 95..102; 104..106; 108..110; 119..122; 124..126; 131..138; 140..142; 146..148; 244..252; 257..263; 267..269; 272..280; 307..315; 318..326; 385..387; 393..395
3D Structure
Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (17)

Domain & Motif Annotations

Domain (FT)
244..544; Protein kinase
Region
439..567; Sufficient for interaction with CLU
Protein Families
  • Protein kinase superfamily
  • TKL Ser/Thr protein kinase family
  • TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance
Related Diseases
Solid tumour/cancer
Biomarker
Phase 1
Drugs
IRINOTECAN HYDROCHLORIDEHESPERETIN
Interaction Protein
ENSG00000119699ENSG00000136536ENSG00000179820
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_bioplex