EV MemProt Atlas

Basic Information

Protein Names

TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Cardiovascular diseases:Vascular diseases
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Predicted secreted proteins
Kinases:TKL Ser/Thr protein kinases
Disease related genes
FDA approved drug targets:Biotech drugs

Transmembrane

167..187; Helical

Transmembrane Count

1

Ensembl

ENSG00000163513

Entrez Gene Symbol

TGFBR2

Frequency

1

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Cancer-related genes:Mutational cancer driver genes
Human disease related genes:Cancers:Cancers of the digestive system
Human disease related genes:Cardiovascular diseases:Vascular diseases
ENZYME proteins:Transferases
Cancer-related genes:Mutated cancer genes
Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
Enzymes
Predicted secreted proteins
Kinases:TKL Ser/Thr protein kinases
Disease related genes
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M141 Pid pi3kci pathway

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TGFBR2	SRC	P12931	Y	284	phosphorylation	Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:16859511 SIGNOR:19114990 ProtMapper:26357075 ProtMapper:17440088 ProtMapper:21532881 ProtMapper:19114990
TGFBR2	SRC	P12931	Y	309	phosphorylation	MIMPPhosphoSite_MIMP
TGFBR2	CSNK1D	P48730	S	213	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling

71 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	Yes	Yes	No
receptor	receptor	GO_Intercell	No	Yes	Yes	Yes	No
receptor	receptor	HPMR	No	Yes	Yes	Yes	No
receptor	receptor	ICELLNET	No	Yes	Yes	Yes	No
receptor	receptor	CellChatDB	No	Yes	Yes	Yes	No
receptor	receptor	CellTalkDB	No	Yes	Yes	Yes	No
receptor	receptor	Surfaceome	No	Yes	Yes	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	Yes	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	Yes	Yes	No
receptor	receptor	LRdb	No	Yes	Yes	Yes	No

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Regulatory Interaction Network

20 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TGFB1	P01137	TGFR2	P37173	Yes	Yes	No	iTALKSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDCui2007IntActDLRP_talklrCancerCellMapRamilowski2015_Baccin2019ACSN_SignaLink3Ramilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	SIGNOR:26194464 IntAct:20856203 SignaLink3:2871107 SignaLink3:11013220 SignaLink3:16446785 Lit-BM-17:11157754 HINT:20207738 SignaLink3:24403530 SignaLink3:11279127 SignaLink3:23784029 Baccin2019:12809600 LRdb:7935686 HINT:10026191 SignaLink3:19920116 SignaLink3:18855897 SignaLink3:22943793 DIP:10026191 SignaLink3:12809600 SignaLink3:21041659 SignaLink3:9865696 SignaLink3:11278410 CellTalkDB:10716993 HINT:7878020 SignaLink3:17070508 Lit-BM-17:21054789 SignaLink3:17768418 IntAct:21441952 SignaLink3:15265520 Lit-BM-17:7706250 HINT:7521335 HINT:8389764 SignaLink3:14557817 SignaLink3:24132110 SignaLink3:16572188 InnateDB:15034927 Baccin2019:7935686 CancerCellMap:12729750 HINT:9261125 SignaLink3:12724770 CancerCellMap:8106553 SignaLink3:24336330 Lit-BM-17:8242742 SignaLink3:17979848 Lit-BM-17:10026191 connectomeDB2020:7935686 SignaLink3:8515656 Lit-BM-17:20860622 DIP:7878020 SignaLink3:11792802 SignaLink3:7594497 SignaLink3:15761153 HINT:20860622 SPIKE:11382746 connectomeDB2020:10716993 SignaLink3:21071413 LRdb:10716993 SignaLink3:21900405 NetPath:8047140 SignaLink3:19050695 HPMR:12809600 SignaLink3:17934056 SignaLink3:20616810 SPIKE_LC:11382746 SignaLink3:15099563 SignaLink3:16200688 SignaLink3:26201938 SignaLink3:11157754 SignaLink3:22703233 CancerCellMap:11382746 HINT:35443807 SPIKE_LC:7852346 SignaLink3:18922473 SignaLink3:19747910 SignaLink3:20519943 SignaLink3:10678166 Lit-BM-17:7878020 InnateDB:18382895 HPRD:7935686 SignaLink3:16474430 Lit-BM-17:9261125 connectomeDB2020:12809600 SignaLink3:9311995 SignaLink3:26192618 SignaLink3:12717440 SignaLink3:16127449 SignaLink3:15003992 SignaLink3:26966341 LRdb:12809600 SignaLink3:21372296 SignaLink3:19732719 SignaLink3:21098712 SignaLink3:18423981 SignaLink3:21614932 SignaLink3:23070005 DIP:7706250 SignaLink3:12154066 SignaLink3:11274345 SIGNOR:1310899 SignaLink3:17673906 SignaLink3:22949611 NetPath:11323414 NetPath:1333888 SignaLink3:22874531 HINT:7706250 IntAct:21054789 HPMR:10716993 SignaLink3:17404308 DIP:9261125 IntAct:20860622 SignaLink3:19010789 SignaLink3:15282297 HINT:21441952 SignaLink3:12738796 SignaLink3:22710166 SignaLink3:15761148 SignaLink3:18490733 SignaLink3:15548370 SignaLink3:15653932 SignaLink3:16424049 SignaLink3:20538542 SignaLink3:23034983 SignaLink3:20644162 SignaLink3:18758450 SignaLink3:22315516 HINT:21054789 SPIKE:7852346 IntAct:35443807 SignaLink3:19038247 Baccin2019:10716993 SignaLink3:23331499 SignaLink3:20060931 SignaLink3:19109155 SignaLink3:21278795 SignaLink3:12767520 SignaLink3:11133108
TGFR2	P37173	TRAF6	Q9Y4K3	Yes	Yes	No	NetPathACSN_SignaLink3SignaLink3ACSN	ACSN:16474430 SignaLink3:14557817 SignaLink3:22703233 SignaLink3:24132110 ACSN:11133108 SignaLink3:19114990 SignaLink3:19010789 ACSN:19920116 SignaLink3:11013220 ACSN:22710166 ACSN:17934056 SignaLink3:22710166 SignaLink3:18922473 ACSN:21900405 ACSN:12809600 SignaLink3:20519943 ACSN:18758450 SignaLink3:12724770 SignaLink3:15548370 SignaLink3:24336330 SignaLink3:19920116 SignaLink3:20644162 SignaLink3:16474430 ACSN:20519943 ACSN:18922473 SignaLink3:18758450 SignaLink3:22943793 SignaLink3:26192618 SignaLink3:12717440 SignaLink3:7594497 SignaLink3:12809600 ACSN:15548370 ACSN:14557817 SignaLink3:23331499 SignaLink3:20060931 SignaLink3:9865696 NetPath:18922473 SignaLink3:21900405 SignaLink3:21614932 SignaLink3:19109155 SignaLink3:19050695 ACSN:22943793 ACSN:19010789 SignaLink3:12154066 SignaLink3:21278795 SignaLink3:17934056 SignaLink3:12767520 SignaLink3:11133108 SignaLink3:15265520 SignaLink3:17673906
SRC	P12931	TGFR2	P37173	Yes	Yes	No	Sparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSignaLink3SIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapper	ProtMapper:34193161 ProtMapper:16859511 SIGNOR:19114990 ProtMapper:26357075 ProtMapper:26849234 ProtMapper:17440088 ProtMapper:21532881 ProtMapper:19114990 SignaLink3:19114990 SignaLink3:23331499
TGFR2	P37173	M3K7	O43318	Yes	Yes	No	WangSignaLink3	SignaLink3:23331499 SignaLink3:16360132
TGFR2	P37173	UBP2	O75604	Yes	Yes	No	SIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:29490279
SMUF1	Q9HCE7	TGFR2	P37173	Yes	No	Yes	NetPathSIGNORBioGRIDACSNCancerCellMapWang	ACSN:21572392 ACSN:15761148 NetPath:11278251 NetPath:15221015 SIGNOR:22298955 BioGRID:27048878 CancerCellMap:11278251 ACSN:22949611
TGFR2	P37173		COMPLEX:P27986_P42336	Yes	Yes	No	SIGNOR	SIGNOR:9435577 SIGNOR:19114990
SMUF2	Q9HAU4	TGFR2	P37173	Yes	No	Yes	NetPathWangSIGNOR	SIGNOR:11163210 SIGNOR:22298955 NetPath:15221015
HS90A	P07900	TGFR2	P37173	Yes	Yes	No	SIGNOR	SIGNOR:18591668
TGFR2	P37173	P85B	O00459	Yes	Yes	No	NetPathPhosphoPointSIGNORHPRDCui2007CancerCellMapWang	HPRD:9435577 SIGNOR:9435577 CancerCellMap:9435577 NetPath:9435577

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Protein Complex Composition

6 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ACVR1B_TGFbR2	ACVR1B TGFBR2	P36896 P37173	0:0	CellinkerCellChatDB
ACVR1C_TGFbR2	ACVR1C TGFBR2	P37173 Q8NER5	0:0	CellinkerCellChatDB
TGF-beta receptor II-TGF-beta3 complex	TGFB3 TGFBR2	P10600 P37173	1:1	CompleatCORUMPDB	CORUM:3025Compleat:HC656PDB:1ktz	16289576 11850637
TGF-beta-receptor type II homodimer complex	TGFBR2	P37173	0	CORUM	CORUM:3041	7521335
TGFbeta_receptor2	ACVR1 TGFBR2	P37173 Q04771	1:1	CellPhoneDB	CellPhoneDB:TGFbeta_receptor2
	TGFB2 TGFBR2	P37173 P61812	1:1	PDB	PDB:5tx4PDB:5ty4

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Western blottingFlow cytometry	2	30646616 38321535

Sequence, Structure & Domains

Sequences

Length

567

Mass

64,568

Sequence

MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=betaR-II; IsoId=P37173-1; Sequence=Displayed; Name=2; Synonyms=betaR-IIB; IsoId=P37173-2; Sequence=VSP_012157; Name=3; Synonyms=TbetaRII-SE; IsoId=P37173-3; Sequence=VSP_061513, VSP_061514

Alternative Sequence

31..32; SV -> SDVEMEAQKDEIICPSCNRTAHPLRHI (in isoform 2); 68..80; MSNCSITSICEKP -> FSKVHYEGKKKAW (in isoform 3); 81..567; Missing (in isoform 3)

3D Structural Models

Turn

114..117; 297..299; 473..477; 492..494

Helix

143..145; 151..153; 281..283; 284..294; 333..339; 344..362; 382..384; 410..413; 422..424; 427..430; 440..459; 462..464; 484..491; 502..506; 508..520; 525..527; 531..539

Beta Strand

40..45; 50..52; 55..58; 65..68; 74..76; 78..81; 83..90; 95..102; 104..106; 108..110; 119..122; 124..126; 131..138; 140..142; 146..148; 244..252; 257..263; 267..269; 272..280; 307..315; 318..326; 385..387; 393..395

3D Structure

Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (17)

Domain & Motif Annotations

Domain (FT)

244..544; Protein kinase

Region

439..567; Sufficient for interaction with CLU

Protein Families

Protein kinase superfamily
TKL Ser/Thr protein kinase family
TGFB receptor subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Clinical Relevance

Related Diseases

Solid tumour/cancer

Biomarker

Phase 1

Drugs

IRINOTECAN HYDROCHLORIDE HESPERETIN

Interaction Protein

ENSG00000119699ENSG00000136536ENSG00000179820

Interaction Count

3

Interaction Dataset

intact_biogridbiogrid_bioplex

Entry name TGFR2	UniProt ID P37173	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

TGFR2