Protein detail

TGFR2

TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

Entry name
TGFR2
UniProt ID
P37173
EVMP confidence score
0.50
Supporting publications (n)
1
Transmembrane count
1
Protein classification
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information8
Protein Names
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Protein Function (11)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Predicted secreted proteins
  • Kinases:TKL Ser/Thr protein kinases
  • Disease related genes
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Transmembrane
167..187; Helical
Transmembrane Count
1
Ensembl
ENSG00000163513
Entrez Gene Symbol
TGFBR2
Supporting publications (n)
1
EVMP confidence score
0.50
Function & Pathway8
Protein Function (11)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cardiovascular diseases:Vascular diseases
  • ENZYME proteins:Transferases
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
  • Enzymes
  • Predicted secreted proteins
  • Kinases:TKL Ser/Thr protein kinases
  • Disease related genes
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Cellular Component (10)
Molecular Function (16)
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Biological Process (3)
KEGG (23)
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Reactome (13)
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Canonical Pathways
M141 Pid pi3kci pathway
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence101

Enzyme-Mediated Modification (3)

3 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
TGFBR2SRCP12931Y284phosphorylationSparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:16859511SIGNOR:19114990ProtMapper:26357075ProtMapper:17440088ProtMapper:21532881ProtMapper:19114990
TGFBR2SRCP12931Y309phosphorylationMIMPPhosphoSite_MIMP
TGFBR2CSNK1DP48730S213phosphorylationKEAKEA:17570479

Ligand-Receptor Signaling (71)

71 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorCellPhoneDBNoYesYesYesNo
receptorreceptorGO_IntercellNoYesYesYesNo
receptorreceptorHPMRNoYesYesYesNo
receptorreceptorICELLNETNoYesYesYesNo
receptorreceptorCellChatDBNoYesYesYesNo
receptorreceptorCellTalkDBNoYesYesYesNo
receptorreceptorSurfaceomeNoYesYesYesNo
receptorreceptorRamilowski2015NoYesYesYesNo
receptorreceptorGuide2PharmaNoYesYesYesNo
receptorreceptorLRdbNoYesYesYesNo
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Regulatory Interaction Network (20)

20 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
TGFB1P01137TGFR2P37173YesYesNoiTALKSIGNORHINTSignaLink3InnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrHPRDCui2007IntActDLRP_talklrCancerCellMapRamilowski2015_Baccin2019ACSN_SignaLink3Ramilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKESIGNOR:26194464IntAct:20856203SignaLink3:2871107SignaLink3:11013220SignaLink3:16446785Lit-BM-17:11157754HINT:20207738SignaLink3:24403530SignaLink3:11279127SignaLink3:23784029Baccin2019:12809600LRdb:7935686HINT:10026191SignaLink3:19920116SignaLink3:18855897SignaLink3:22943793DIP:10026191SignaLink3:12809600SignaLink3:21041659SignaLink3:9865696SignaLink3:11278410CellTalkDB:10716993HINT:7878020SignaLink3:17070508Lit-BM-17:21054789SignaLink3:17768418IntAct:21441952SignaLink3:15265520Lit-BM-17:7706250HINT:7521335HINT:8389764SignaLink3:14557817SignaLink3:24132110SignaLink3:16572188InnateDB:15034927Baccin2019:7935686CancerCellMap:12729750HINT:9261125SignaLink3:12724770CancerCellMap:8106553SignaLink3:24336330Lit-BM-17:8242742SignaLink3:17979848Lit-BM-17:10026191connectomeDB2020:7935686SignaLink3:8515656Lit-BM-17:20860622DIP:7878020SignaLink3:11792802SignaLink3:7594497SignaLink3:15761153HINT:20860622SPIKE:11382746connectomeDB2020:10716993SignaLink3:21071413LRdb:10716993SignaLink3:21900405NetPath:8047140SignaLink3:19050695HPMR:12809600SignaLink3:17934056SignaLink3:20616810SPIKE_LC:11382746SignaLink3:15099563SignaLink3:16200688SignaLink3:26201938SignaLink3:11157754SignaLink3:22703233CancerCellMap:11382746HINT:35443807SPIKE_LC:7852346SignaLink3:18922473SignaLink3:19747910SignaLink3:20519943SignaLink3:10678166Lit-BM-17:7878020InnateDB:18382895HPRD:7935686SignaLink3:16474430Lit-BM-17:9261125connectomeDB2020:12809600SignaLink3:9311995SignaLink3:26192618SignaLink3:12717440SignaLink3:16127449SignaLink3:15003992SignaLink3:26966341LRdb:12809600SignaLink3:21372296SignaLink3:19732719SignaLink3:21098712SignaLink3:18423981SignaLink3:21614932SignaLink3:23070005DIP:7706250SignaLink3:12154066SignaLink3:11274345SIGNOR:1310899SignaLink3:17673906SignaLink3:22949611NetPath:11323414NetPath:1333888SignaLink3:22874531HINT:7706250IntAct:21054789HPMR:10716993SignaLink3:17404308DIP:9261125IntAct:20860622SignaLink3:19010789SignaLink3:15282297HINT:21441952SignaLink3:12738796SignaLink3:22710166SignaLink3:15761148SignaLink3:18490733SignaLink3:15548370SignaLink3:15653932SignaLink3:16424049SignaLink3:20538542SignaLink3:23034983SignaLink3:20644162SignaLink3:18758450SignaLink3:22315516HINT:21054789SPIKE:7852346IntAct:35443807SignaLink3:19038247Baccin2019:10716993SignaLink3:23331499SignaLink3:20060931SignaLink3:19109155SignaLink3:21278795SignaLink3:12767520SignaLink3:11133108
TGFR2P37173TRAF6Q9Y4K3YesYesNoNetPathACSN_SignaLink3SignaLink3ACSNACSN:16474430SignaLink3:14557817SignaLink3:22703233SignaLink3:24132110ACSN:11133108SignaLink3:19114990SignaLink3:19010789ACSN:19920116SignaLink3:11013220ACSN:22710166ACSN:17934056SignaLink3:22710166SignaLink3:18922473ACSN:21900405ACSN:12809600SignaLink3:20519943ACSN:18758450SignaLink3:12724770SignaLink3:15548370SignaLink3:24336330SignaLink3:19920116SignaLink3:20644162SignaLink3:16474430ACSN:20519943ACSN:18922473SignaLink3:18758450SignaLink3:22943793SignaLink3:26192618SignaLink3:12717440SignaLink3:7594497SignaLink3:12809600ACSN:15548370ACSN:14557817SignaLink3:23331499SignaLink3:20060931SignaLink3:9865696NetPath:18922473SignaLink3:21900405SignaLink3:21614932SignaLink3:19109155SignaLink3:19050695ACSN:22943793ACSN:19010789SignaLink3:12154066SignaLink3:21278795SignaLink3:17934056SignaLink3:12767520SignaLink3:11133108SignaLink3:15265520SignaLink3:17673906
SRCP12931TGFR2P37173YesYesNoSparser_ProtMapperPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperRLIMS-P_ProtMapperSignaLink3SIGNOR_ProtMapperREACH_ProtMapperPhosphoSite_ProtMapperProtMapper:34193161ProtMapper:16859511SIGNOR:19114990ProtMapper:26357075ProtMapper:26849234ProtMapper:17440088ProtMapper:21532881ProtMapper:19114990SignaLink3:19114990SignaLink3:23331499
TGFR2P37173M3K7O43318YesYesNoWangSignaLink3SignaLink3:23331499SignaLink3:16360132
TGFR2P37173UBP2O75604YesYesNoSIGNORPhosphoSite_ProtMapperProtMapperSIGNOR:29490279
SMUF1Q9HCE7TGFR2P37173YesNoYesNetPathSIGNORBioGRIDACSNCancerCellMapWangACSN:21572392ACSN:15761148NetPath:11278251NetPath:15221015SIGNOR:22298955BioGRID:27048878CancerCellMap:11278251ACSN:22949611
TGFR2P37173COMPLEX:P27986_P42336YesYesNoSIGNORSIGNOR:9435577SIGNOR:19114990
SMUF2Q9HAU4TGFR2P37173YesNoYesNetPathWangSIGNORSIGNOR:11163210SIGNOR:22298955NetPath:15221015
HS90AP07900TGFR2P37173YesYesNoSIGNORSIGNOR:18591668
TGFR2P37173P85BO00459YesYesNoNetPathPhosphoPointSIGNORHPRDCui2007CancerCellMapWangHPRD:9435577SIGNOR:9435577CancerCellMap:9435577NetPath:9435577
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Protein Complex Composition (6)

6 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACVR1B_TGFbR2ACVR1BTGFBR2P36896P371730:0CellinkerCellChatDB
ACVR1C_TGFbR2ACVR1CTGFBR2P37173Q8NER50:0CellinkerCellChatDB
TGF-beta receptor II-TGF-beta3 complexTGFB3TGFBR2P10600P371731:1CompleatCORUMPDBCORUM:3025Compleat:HC656PDB:1ktz1628957611850637
TGF-beta-receptor type II homodimer complexTGFBR2P371730CORUMCORUM:30417521335
TGFbeta_receptor2ACVR1TGFBR2P37173Q047711:1CellPhoneDBCellPhoneDB:TGFbeta_receptor2
TGFB2TGFBR2P37173P618121:1PDBPDB:5tx4PDB:5ty4

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyWestern blottingFlow cytometry23064661638321535
Sequence, Structure & Domains13

Sequences

Length
567
Mass
64,568
Sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=betaR-II; IsoId=P37173-1; Sequence=Displayed; Name=2; Synonyms=betaR-IIB; IsoId=P37173-2; Sequence=VSP_012157; Name=3; Synonyms=TbetaRII-SE; IsoId=P37173-3; Sequence=VSP_061513, VSP_061514
Alternative Sequence
31..32; SV -> SDVEMEAQKDEIICPSCNRTAHPLRHI (in isoform 2); 68..80; MSNCSITSICEKP -> FSKVHYEGKKKAW (in isoform 3); 81..567; Missing (in isoform 3)

3D Structural Models

Turn
114..117; 297..299; 473..477; 492..494
Helix
143..145; 151..153; 281..283; 284..294; 333..339; 344..362; 382..384; 410..413; 422..424; 427..430; 440..459; 462..464; 484..491; 502..506; 508..520; 525..527; 531..539
Beta Strand
40..45; 50..52; 55..58; 65..68; 74..76; 78..81; 83..90; 95..102; 104..106; 108..110; 119..122; 124..126; 131..138; 140..142; 146..148; 244..252; 257..263; 267..269; 272..280; 307..315; 318..326; 385..387; 393..395
3D Structure
Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (17)

Domain & Motif Annotations

Domain (FT)
244..544; Protein kinase
Region
439..567; Sufficient for interaction with CLU
Protein Families (3)
  • Protein kinase superfamily
  • TKL Ser/Thr protein kinase family
  • TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance6
Related Diseases
Solid tumour/cancer
Biomarker
Phase 1
Drugs (2)
IRINOTECAN HYDROCHLORIDEHESPERETIN
Interaction Protein (3)
ENSG00000119699ENSG00000136536ENSG00000179820
Interaction Count
3
Interaction Dataset (2)
intact_biogridbiogrid_bioplex
Supporting Publications1
PMIDTitleAbstract
34771645GCC2 as a New Early Diagnostic Biomarker for Non-Small Cell Lung Cancer.No abstract available