Protein detail

CAP2

Adenylyl cyclase-associated protein 2 (CAP 2)

Protein symbol CAP2	UniProt ID P40123	EVMP score 0.50
Frequency 9	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteins

Basic Information

Protein Names

Adenylyl cyclase-associated protein 2 (CAP 2)

Protein Class

Cancer-related genesPredicted intracellular proteins

Protein Function

Cancer-related genes:Mutated cancer genes
Predicted intracellular proteins

Ensembl

ENSG00000112186

Entrez Gene Symbol

CAP2

Gene Description

Cyclase associated actin cytoskeleton regulatory protein 2

Chromosome

Position

17393595-17557780

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificlymphoid tissueCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificmonocytes

Function & Pathway

Protein Function

Cancer-related genes:Mutated cancer genes
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Regulatory Interaction Network

0 records.

Protein Complex Composition

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AP2A2 NECAP1 NECAP2	O94973 Q8NC96 Q9NVZ3	0:0:0	hu.MAP2
ASNS CAP1 CAP2 GALE GARS1	P08243 P40123 P41250 Q01518 Q14376	0:0:0:0:0	hu.MAP
ACLY CAP2 TOM1L2	P40123 P53396 Q6ZVM7	0:0:0	hu.MAP2
CRIP2 NECAP1 NECAP2 PHPT1	P52943 Q8NC96 Q9NRX4 Q9NVZ3	0:0:0:0	hu.MAP2
NECAP1 NECAP2	Q8NC96 Q9NVZ3	0:0	hu.MAP
BCAP29	Q9UHQ4	2	PDB	PDB:4w7zPDB:4w7yPDB:4w80

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	3	31382537 27821849 38716512

Sequence, Structure & Domains

Sequences

Length

477

Mass

52,824

Sequence

MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40123-1; Sequence=Displayed; Name=2; IsoId=P40123-2; Sequence=VSP_055520; Name=3; IsoId=P40123-3; Sequence=VSP_055519

Alternative Sequence

75..334; Missing (in isoform 3); 149..212; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

230..246; Pro residues; 298..320; Low complexity

Domain (FT)

317..455; C-CAP/cofactor C-like

Region

225..261; Disordered; 274..321; Disordered

Protein Families

CAP family

Sequence Similarities

Belongs to the CAP family.

Clinical Relevance

Disease Involvement

Cancer-related genesCardiomyopathyDisease variant

Antibody

HPA050530 HPA054147

Interaction Protein

ENSG00000075624ENSG00000143632ENSG00000172757ENSG00000184009

Interaction Count

Interaction Dataset

intact_biogrid_opencell_bioplexbiogrid_bioplexintact_biogrid_opencell