Protein detail

CAP2

Adenylyl cyclase-associated protein 2 (CAP 2)

Entry name CAP2	UniProt ID P40123	EVMP confidence score 0.50
Supporting publications (n) 9	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information10

Protein Names

Adenylyl cyclase-associated protein 2 (CAP 2)

Protein Class (2)

Cancer-related genesPredicted intracellular proteins

Protein Function (2)

Cancer-related genes:Mutated cancer genes
Predicted intracellular proteins

Ensembl

ENSG00000112186

Entrez Gene Symbol

CAP2

Gene Description

Cyclase associated actin cytoskeleton regulatory protein 2

Chromosome

Position

17393595-17557780

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization6

Tissue Specificlymphoid tissueCell SpecificEsophageal apical cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificclassical monocyteBlood Lineage Specificmonocytes

Function & Pathway6

Protein Function (2)

Cancer-related genes:Mutated cancer genes
Predicted intracellular proteins

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

Reactome (3)

Mediation Categories

Fusion and delivery mediation

Relations & Evidence22

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (16)

16 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
AP2A2 NECAP1 NECAP2	O94973 Q8NC96 Q9NVZ3	0:0:0	hu.MAP2
ASNS CAP1 CAP2 GALE GARS1	P08243 P40123 P41250 Q01518 Q14376	0:0:0:0:0	hu.MAP
ACLY CAP2 TOM1L2	P40123 P53396 Q6ZVM7	0:0:0	hu.MAP2
CRIP2 NECAP1 NECAP2 PHPT1	P52943 Q8NC96 Q9NRX4 Q9NVZ3	0:0:0:0	hu.MAP2
NECAP1 NECAP2	Q8NC96 Q9NVZ3	0:0	hu.MAP
BCAP29	Q9UHQ4	2	PDB	PDB:4w7zPDB:4w7yPDB:4w80

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometryR Sequencing	3	31382537 27821849 38716512

Sequence, Structure & Domains10

Sequences

Length

477

Mass

52,824

Sequence

MANMQGLVERLERAVSRLESLSAESHRPPGNCGEVNGVIAGVAPSVEAFDKLMDSMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKEHHTTGLTWSKTGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQKHAPVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPIPEQFKTAWDGSKLITEPAEIMA

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40123-1; Sequence=Displayed; Name=2; IsoId=P40123-2; Sequence=VSP_055520; Name=3; IsoId=P40123-3; Sequence=VSP_055519

Alternative Sequence

75..334; Missing (in isoform 3); 149..212; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

230..246; Pro residues; 298..320; Low complexity

Domain (FT)

317..455; C-CAP/cofactor C-like

Region

225..261; Disordered; 274..321; Disordered

Protein Families

CAP family

Sequence Similarities

Belongs to the CAP family.

Clinical Relevance5

Disease Involvement (3)

Cancer-related genesCardiomyopathyDisease variant

Antibody (2)

HPA050530 HPA054147

Interaction Protein (4)

ENSG00000075624ENSG00000143632ENSG00000172757ENSG00000184009

Interaction Count

Interaction Dataset (3)

intact_biogrid_opencell_bioplexbiogrid_bioplexintact_biogrid_opencell

Supporting Publications9

PMID	Title	Abstract
27487081	Comparative Proteomic Analysis of Extracellular Vesicles Isolated by Acoustic Trapping or Differential Centrifugation.	No abstract available
32230970	Radiation Exposure of Peripheral Mononuclear Blood Cells Alters the Composition and Function of Secreted Extracellular Vesicles.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
37204515	Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
40465195	Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome.	No abstract available
40840701	Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma.	No abstract available