Protein detail

TPOR

Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)

Entry name TPOR	UniProt ID P40238	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)

Protein Function (8)

Human disease related genes:Cardiovascular diseases:Hematologic diseases
Predicted intracellular proteins
CD markers
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

492..513; Helical

Transmembrane Count

Ensembl

ENSG00000117400

Entrez Gene Symbol

MPL

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (8)

Human disease related genes:Cardiovascular diseases:Hematologic diseases
Predicted intracellular proteins
CD markers
Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
Cancer-related genes
Disease related genes
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component (6)

Molecular Function (2)

Biological Process (3)

KEGG (3)

Reactome (3)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence72

Ligand-Receptor Signaling (65)

65 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	DGIdb	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TPOR	P40238	JAK2	O60674	Yes	Yes	No	KEGG-MEDICUSHPRDSignaLink3WangLit-BM-17	Lit-BM-17:24931576 HPRD:10918061 HPRD:10224114 HPRD:7534285 SignaLink3:23331499 HPRD:10979953 SignaLink3:7543416
TPO	P40225	TPOR	P40238	Yes	Yes	No	iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3DIPHPMR_talklrCellChatDBHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDDLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrCellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	SignaLink3:9766811 LRdb:10495959 Cellinker:10495959LRdb:98connectomeDB2020:9766811 Cellinker:8521814 HINT:37633268 connectomeDB2020:10495959 Cellinker:9766811 SignaLink3:23331499 HPRD:9766811 ICELLNET:11784712 DIP:9252374 SignaLink3:7543416 SIGNOR:11784712 CellTalkDB:10495959
TPOR	P40238	TYK2	P29597	Yes	Yes	No	WangSignaLink3	SignaLink3:7543416 SignaLink3:23331499
ATX2L	Q8WWM7	TPOR	P40238	Yes	No	Yes	HPRDSPIKE_LCLit-BM-17SIGNOR	Lit-BM-17:11784712 SIGNOR:11784712 SPIKE_LC:16713569 HPRD:11784712

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MPL THPO	P40225 P40238	1:2	PDB	PDB:8g04
	DBR1 MPLKIP	Q8TAP9 Q9UK59	0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains15

Sequences

Length

635

Mass

71,245

Sequence

MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=C-mpl-P; IsoId=P40238-1; Sequence=Displayed; Name=2; Synonyms=C-mpl-K; IsoId=P40238-2; Sequence=VSP_001734, VSP_001735

Alternative Sequence

523..579; RLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTP -> YRPRQAGDWRWTRWSRTCKQAFLVRSVTPDLRPPPVRTYGFALPARHLWDSPRLLTL (in isoform 2); 580..635; Missing (in isoform 2)

3D Structural Models

Turn

114..116; 262..264; 295..297

Helix

28..30; 127..129; 159..161; 190..192; 284..287; 385..387

Beta Strand

37..41; 43..46; 49..56; 63..68; 70..72; 75..77; 79..83; 85..87; 89..93; 106..113; 119..126; 139..143; 149..155; 164..173; 183..187; 238..244; 248..260; 276..279; 292..294; 298..304; 309..320; 349..354; 359..371; 374..379; 396..400; 406..410; 421..428; 436..438; 446..449; 458..466; 468..474

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Motif

474..478; WSXWS motif; 528..536; Box 1 motif

Domain (CC)

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.

Domain (FT)

172..281; Fibronectin type-III 1; 392..486; Fibronectin type-III 2

Region

205..232; Disordered

Protein Families (2)

Type I cytokine receptor family
Type 1 subfamily

Sequence Similarities

Belongs to the type I cytokine receptor family. Type 1 subfamily.

Clinical Relevance3

Related Diseases (8)

Acute myeloid leukaemia Ischaemic/haemorrhagic stroke Liver disease Multiple myeloma Myelodysplastic syndrome Myocardial infarction Thrombocytopenia Transplanted organ/tissue

Biomarker

Investigative; Phase 1; Phase 3; Phase 2; Approved; Terminated

Drugs (12)

LUSUTROMBOPAG AVATROMBOPAG MALEATE ROMIPLOSTIM ELTROMBOPAG SB-559448 AVATROMBOPAG NULL HETROMBOPAG TOTROMBOPAG RAFUTROMBOPAG THROMBOPOIETIN HETROMBOPAG OLAMINE

Supporting Publications5

PMID	Title	Abstract
32854315	Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study.	Recent studies have highlighted the importance of Aβ and tau-containing extracellular vesicles (EVs) in AD.
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available
38113368	In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available