Protein detail
OX2G
OX-2 membrane glycoprotein (CD antigen CD200)
Entry name OX2G | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
OX-2 membrane glycoprotein (CD antigen CD200)
Protein Class (3)
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Transmembrane
233..259; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
MOX1MOX2MRCOX-2
Gene Description
CD200 molecule
Chromosome
3
Position
112332347-112362812
Supporting publications (n)
3
EVMP confidence score
0.53
Fluorescence & Localization
Tissue SpecificbreastCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence38
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | OmniPath | Yes | ||||
| plasma_membrane | plasma_membrane | UniProt_location | Yes | ||||
| plasma_membrane | plasma_membrane | Cellinker | Yes | ||||
| plasma_membrane | plasma_membrane | OmniPath | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | Membranome | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | Yes | ||||
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | Yes | ||||
| cell_surface | cell_surface | Surfaceome | Yes | ||||
| cell_surface | cell_surface | connectomeDB2020 | Yes | ||||
| cell_surface | cell_surface | OmniPath | Yes |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
278
Mass
31,264
Sequence
MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41217-1; Sequence=Displayed; Name=2; IsoId=P41217-2; Sequence=VSP_002613; Name=3; IsoId=P41217-3; Sequence=VSP_040027, VSP_002613
Alternative Sequence
4; L -> LTLTRTIGGPLLTATLLGKTTINDYQ (in isoform 3); 268..278; GELSQGVQKMT -> EP (in isoform 2 and isoform 3)
Domain & Motif Annotations
Domain (FT)
31..141; Ig-like V-type; 142..232; Ig-like C2-type
Clinical Relevance
Related Diseases (3)
Biomarker
Phase 2; Phase 1/2; Phase 1
Drugs
Antibody
Supporting Publications3
| PMID | Title | Related sentences |
|---|---|---|
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No related sentences available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40928027 | Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes. | No related sentences available |