Protein detail
OX2G
OX-2 membrane glycoprotein (CD antigen CD200)
Entry name OX2G | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 1 | Protein classification CD markersPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
OX-2 membrane glycoprotein (CD antigen CD200)
Protein Class (3)
CD markersPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Transmembrane
233..259; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
MOX1MOX2MRCOX-2
Gene Description
CD200 molecule
Chromosome
3
Position
112332347-112362812
Supporting publications (n)
3
EVMP confidence score
0.25
Fluorescence & Localization3
Tissue SpecificbreastCell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway6
Protein Function (2)
- CD markers
- Predicted intracellular proteins
Cellular Component (7)
Molecular Function (4)
Biological Process (3)
Reactome (2)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence38
Ligand-Receptor Signaling (37)
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ligand | ligand | ICELLNET | Yes | No | No | Yes | No |
| ligand | ligand | CellTalkDB | Yes | No | No | Yes | No |
| ligand | ligand | LRdb | Yes | No | No | Yes | No |
| ligand | ligand | OmniPath | Yes | No | No | Yes | No |
| receptor | receptor | Cellinker | No | Yes | No | Yes | No |
| receptor | receptor | connectomeDB2020 | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains6
Sequences
Length
278
Mass
31,264
Sequence
MERLVIRMPFSHLSTYSLVWVMAAVVLCTAQVQVVTQDEREQLYTPASLKCSLQNAQEALIVTWQKKKAVSPENMVTFSENHGVVIQPAYKDKINITQLGLQNSTITFWNITLEDEGCYMCLFNTFGFGKISGTACLTVYVQPIVSLHYKFSEDHLNITCSATARPAPMVFWKVPRSGIENSTVTLSHPNGTTSVTSILHIKDPKNQVGKEVICQVLHLGTVTDFKQTVNKGYWFSVPLLLSIVSLVILLVLISILLYWKRHRNQDRGELSQGVQKMT
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41217-1; Sequence=Displayed; Name=2; IsoId=P41217-2; Sequence=VSP_002613; Name=3; IsoId=P41217-3; Sequence=VSP_040027, VSP_002613
Alternative Sequence
4; L -> LTLTRTIGGPLLTATLLGKTTINDYQ (in isoform 3); 268..278; GELSQGVQKMT -> EP (in isoform 2 and isoform 3)
Domain & Motif Annotations
Domain (FT)
31..141; Ig-like V-type; 142..232; Ig-like C2-type
Clinical Relevance4
Related Diseases (3)
Biomarker
Phase 2; Phase 1/2; Phase 1
Drugs
Antibody
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 40928027 | Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes. | No abstract available |