Protein detail
S19A1
Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
Entry name S19A1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 5 | Transmembrane count 12 | Protein classification Cancer-related genesDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
Protein Class (6)
Cancer-related genesDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Potential drug targets
Transmembrane
30..50; Helical; Name=1; 65..87; Helical; Name=2; 92..112; Helical; Name=3; 117..139; Helical; Name=4; 154..178; Helical; Name=5; 184..202; Helical; Name=6; 267..292; Helical; Name=7; 305..327; Helical; Name=8; 334..354; Helical; Name=9; 361..384; Helical; Name=10; 399..422; Helical; Name=11; 431..455; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
FOLTRFC1
Gene Description
Solute carrier family 19 member 1
Chromosome
21
Position
45493572-45573365
Supporting publications (n)
5
EVMP confidence score
0.50
Function & Pathway8
Protein Function (4)
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Potential drug targets
Cellular Component (4)
Molecular Function (10)
- GO:0005515 protein binding
- GO:0005542 folic acid binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008517 folic acid transmembrane transporter activity
- GO:0008518 folate:monoatomic anion antiporter activity
- GO:0015297 antiporter activity
- GO:0015350 methotrexate transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0061507 2',3'-cyclic GMP-AMP binding
- GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
Biological Process (3)
KEGG (4)
Reactome (3)
Canonical Pathways
M118 Pid integrin a9b1 pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| basolateral_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains13
Sequences
Length
591
Mass
64,868
Sequence
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41440-1; Sequence=Displayed; Name=2; IsoId=P41440-2; Sequence=VSP_042891; Name=3; IsoId=P41440-3; Sequence=VSP_044497
Alternative Sequence
1..63; MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQ -> MRPQPAEPAPGGRGNEACSIHSE (in isoform 2); 432..591; FQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ -> NEELHVASLSLWKSHLRLAADTLSSEGSSGSGPRSWFLSPTLRAALHGPVCPSEVCPS (in isoform 3)
3D Structural Models
Turn
55..57; 421..424
Helix
20..26; 29..37; 48..52; 61..68; 70..90; 92..111; 116..132; 136..143; 146..148; 149..175; 182..199; 253..262; 267..287; 291..295; 306..323; 324..326; 337..354; 359..361; 362..387; 393..418; 428..452
Beta Strand
45..47; 201..203; 210..213; 301..303; 329..331; 332..334; 388..390
3D Structure
Electron microscopy (19)
Domain & Motif Annotations
Domain (CC)
Has separate binding pockets for folates and cyclic dinucleotides (PubMed:36265513). Two cyclic dinucleotides can be accommodated in the binding pocket and they are likely transported at the same time (PubMed:36265513).
Region
407..419; Required for substrate-binding
Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
Clinical Relevance8
Disease Involvement (3)
Cancer-related genesDisease variantHereditary hemolytic anemia
Related Diseases (7)
Biomarker
Approved; Investigative; Phase 1; Phase 3
Drugs (19)
Antibody
Interaction Protein
ENSG00000049245
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications5
| PMID | Title | Abstract |
|---|---|---|
| 27821849 | Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation. | No abstract available |
| 37322475 | Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration. | No abstract available |
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |
| 40985879 | TurboID-Mediated Profiling of Glioblastoma-Derived Extracellular Vesicle Cargo Proteins. | No abstract available |