Protein detail
S19A1
Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
Protein symbol S19A1 | UniProt ID | EVMP score 0.50 |
Frequency 5 | Transmembrane count 12 | Protein classification Cancer-related genesDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Reduced folate transporter (FOLT) (Cyclic dinucleotide:anion antiporter SLC19A1) (Folate:anion antiporter SLC19A1) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
Protein Class
Cancer-related genesDisease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Potential drug targets
Transmembrane
30..50; Helical; Name=1; 65..87; Helical; Name=2; 92..112; Helical; Name=3; 117..139; Helical; Name=4; 154..178; Helical; Name=5; 184..202; Helical; Name=6; 267..292; Helical; Name=7; 305..327; Helical; Name=8; 334..354; Helical; Name=9; 361..384; Helical; Name=10; 399..422; Helical; Name=11; 431..455; Helical; Name=12
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Gene Synonym
FOLTRFC1
Gene Description
Solute carrier family 19 member 1
Chromosome
21
Position
45493572-45573365
Frequency
5
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Potential drug targets
Cellular Component
Molecular Function
- GO:0005515 protein binding
- GO:0005542 folic acid binding
- GO:0008514 organic anion transmembrane transporter activity
- GO:0008517 folic acid transmembrane transporter activity
- GO:0008518 folate:monoatomic anion antiporter activity
- GO:0015297 antiporter activity
- GO:0015350 methotrexate transmembrane transporter activity
- GO:0042910 xenobiotic transmembrane transporter activity
- GO:0061507 2',3'-cyclic GMP-AMP binding
- GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
Biological Process
KEGG
Reactome
Canonical Pathways
M118 Pid integrin a9b1 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
Page 3 of 3Previous
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
591
Mass
64,868
Sequence
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P41440-1; Sequence=Displayed; Name=2; IsoId=P41440-2; Sequence=VSP_042891; Name=3; IsoId=P41440-3; Sequence=VSP_044497
Alternative Sequence
1..63; MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQ -> MRPQPAEPAPGGRGNEACSIHSE (in isoform 2); 432..591; FQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ -> NEELHVASLSLWKSHLRLAADTLSSEGSSGSGPRSWFLSPTLRAALHGPVCPSEVCPS (in isoform 3)
3D Structural Models
Turn
55..57; 421..424
Helix
20..26; 29..37; 48..52; 61..68; 70..90; 92..111; 116..132; 136..143; 146..148; 149..175; 182..199; 253..262; 267..287; 291..295; 306..323; 324..326; 337..354; 359..361; 362..387; 393..418; 428..452
Beta Strand
45..47; 201..203; 210..213; 301..303; 329..331; 332..334; 388..390
3D Structure
Electron microscopy (19)
Domain & Motif Annotations
Domain (CC)
Has separate binding pockets for folates and cyclic dinucleotides (PubMed:36265513). Two cyclic dinucleotides can be accommodated in the binding pocket and they are likely transported at the same time (PubMed:36265513).
Region
407..419; Required for substrate-binding
Protein Families
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Sequence Similarities
Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantHereditary hemolytic anemia
Related Diseases
Biomarker
Approved; Investigative; Phase 1; Phase 3
Drugs
Antibody
Interaction Protein
ENSG00000049245
Interaction Count
1
Interaction Dataset
biogrid_opencell