Protein detail
PI4KA
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)
Protein symbol PI4KA | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)
Protein Class
Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
PI4K-ALPHApi4K230PIK4CA
Gene Description
Phosphatidylinositol 4-kinase alpha
Chromosome
22
Position
20707691-20859417
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecificcervixCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationIntracellular and membraneSecretome FunctionEnzyme
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
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Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| EFR3B | Q9Y2G0 | PI4KA | P42356 | Yes | Yes | No | SIGNOR | SIGNOR:34504076 |
| EFR3A | Q14156 | PI4KA | P42356 | Yes | Yes | No | SIGNOR | SIGNOR:34504076 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster448 | PI4KATDRD3TOP3B | O95985P42356Q9H7E2 | 1:1:1 | Compleat | Compleat:HC412 | 22036573 |
| CAND2HEATR1PI4KA | O75155P42356Q9H583 | 0:0:0 | hu.MAP | |||
| EIF2DG6PDHARS1PI4KA | P11413P12081P41214P42356 | 0:0:0:0 | Havugimana2012 | Havugimana2012:C_366 | ||
| PI4KA | P42356 | 0 | hu.MAP2 | |||
| PI4KAPLBD1 | P42356Q6P4A8 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
2,102
Mass
236,830
Sequence
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PI4K230; IsoId=P42356-1; Sequence=Displayed; Name=2; Synonyms=PI4K97; IsoId=P42356-2; Sequence=VSP_008805
Alternative Sequence
1..1248; Missing (in isoform 2)
3D Structural Models
Turn
385..387; 581..583; 627..629; 842..844; 910..912; 1538..1540; 1706..1708; 1748..1750; 1905..1907
Helix
31..44; 50..59; 72..87; 93..106; 107..109; 127..145; 150..168; 177..182; 184..191; 204..208; 297..300; 326..339; 343..358; 370..384; 393..413; 434..447; 452..466; 479..495; 500..512; 516..522; 563..580; 587..600; 612..626; 634..643; 653..664; 669..685; 703..705; 707..718; 723..739; 768..770; 771..778; 789..804; 818..827; 858..872; 876..882; 887..906; 913..920; 923..927; 934..951; 959..973; 974..976; 981..996; 998..1000; 1006..1021; 1047..1071; 1073..1084; 1088..1092; 1098..1108; 1137..1156; 1170..1183; 1186..1201; 1208..1215; 1218..1220; 1224..1240; 1245..1262; 1276..1278; 1294..1312; 1316..1325; 1343..1345; 1347..1360; 1370..1385; 1401..1416; 1478..1507; 1520..1533; 1541..1550; 1552..1557; 1558..1560; 1567..1578; 1586..1589; 1590..1592; 1609..1611; 1617..1620; 1621..1624; 1632..1642; 1647..1652; 1654..1659; 1660..1663; 1668..1679; 1682..1693; 1709..1722; 1725..1747; 1755..1767; 1815..1823; 1857..1875; 1916..1924; 1930..1953; 1999..2003; 2011..2027; 2028..2030; 2031..2042; 2053..2060; 2067..2080
Beta Strand
45..47; 200..202; 303..305; 538..540; 630..632; 978..980; 1202..1205; 1241..1243; 1281..1283; 1333..1335; 1367..1369; 1598..1600; 1625..1628; 1696..1700; 1702..1704; 1782..1787; 1803..1811; 1842..1853; 1886..1890; 1893..1898; 1962..1965; 1967..1969; 1971..1973
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Domain (FT)
1530..1718; PIK helical; 1808..2086; PI3K/PI4K catalytic
Region
1814..1820; G-loop; 1954..1962; Catalytic loop; 1973..1997; Activation loop
Protein Families
- PI3/PI4-kinase family
- Type III PI4K subfamily
Sequence Similarities
Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.