Protein detail

PI4KA

Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)

Protein symbol PI4KA	UniProt ID P42356	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)

Protein Class

Disease related genesEnzymesEssential proteinsHuman disease related genesMetabolic proteinsPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Enzymes
Disease related genes

Ensembl

ENSG00000241973

Entrez Gene Symbol

PI4KA

Gene Synonym

PI4K-ALPHApi4K230PIK4CA

Gene Description

Phosphatidylinositol 4-kinase alpha

Chromosome

Position

20707691-20859417

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificcervixCell SpecificAdrenal medulla cellsSingle-Nuclei Brain SpecificastrocyteBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationIntracellular and membraneSecretome FunctionEnzyme

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

12 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	scConnect	No	Yes	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EFR3B	Q9Y2G0	PI4KA	P42356	Yes	Yes	No	SIGNOR	SIGNOR:34504076
EFR3A	Q14156	PI4KA	P42356	Yes	Yes	No	SIGNOR	SIGNOR:34504076

Protein Complex Composition

5 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster448	PI4KA TDRD3 TOP3B	O95985 P42356 Q9H7E2	1:1:1	Compleat	Compleat:HC412	22036573
	CAND2 HEATR1 PI4KA	O75155 P42356 Q9H583	0:0:0	hu.MAP
	EIF2D G6PD HARS1 PI4KA	P11413 P12081 P41214 P42356	0:0:0:0	Havugimana2012	Havugimana2012:C_366
	PI4KA	P42356	0	hu.MAP2
	PI4KA PLBD1	P42356 Q6P4A8	0:0	hu.MAP2

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	38037300

Sequence, Structure & Domains

Sequences

Length

2,102

Mass

236,830

Sequence

MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARKGRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISVTNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPLRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEYMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDIPY

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PI4K230; IsoId=P42356-1; Sequence=Displayed; Name=2; Synonyms=PI4K97; IsoId=P42356-2; Sequence=VSP_008805

Alternative Sequence

1..1248; Missing (in isoform 2)

3D Structural Models

Turn

385..387; 581..583; 627..629; 842..844; 910..912; 1538..1540; 1706..1708; 1748..1750; 1905..1907

Helix

31..44; 50..59; 72..87; 93..106; 107..109; 127..145; 150..168; 177..182; 184..191; 204..208; 297..300; 326..339; 343..358; 370..384; 393..413; 434..447; 452..466; 479..495; 500..512; 516..522; 563..580; 587..600; 612..626; 634..643; 653..664; 669..685; 703..705; 707..718; 723..739; 768..770; 771..778; 789..804; 818..827; 858..872; 876..882; 887..906; 913..920; 923..927; 934..951; 959..973; 974..976; 981..996; 998..1000; 1006..1021; 1047..1071; 1073..1084; 1088..1092; 1098..1108; 1137..1156; 1170..1183; 1186..1201; 1208..1215; 1218..1220; 1224..1240; 1245..1262; 1276..1278; 1294..1312; 1316..1325; 1343..1345; 1347..1360; 1370..1385; 1401..1416; 1478..1507; 1520..1533; 1541..1550; 1552..1557; 1558..1560; 1567..1578; 1586..1589; 1590..1592; 1609..1611; 1617..1620; 1621..1624; 1632..1642; 1647..1652; 1654..1659; 1660..1663; 1668..1679; 1682..1693; 1709..1722; 1725..1747; 1755..1767; 1815..1823; 1857..1875; 1916..1924; 1930..1953; 1999..2003; 2011..2027; 2028..2030; 2031..2042; 2053..2060; 2067..2080

Beta Strand

45..47; 200..202; 303..305; 538..540; 630..632; 978..980; 1202..1205; 1241..1243; 1281..1283; 1333..1335; 1367..1369; 1598..1600; 1625..1628; 1696..1700; 1702..1704; 1782..1787; 1803..1811; 1842..1853; 1886..1890; 1893..1898; 1962..1965; 1967..1969; 1971..1973

3D Structure

Electron microscopy (3)

Domain & Motif Annotations

Domain (FT)

1530..1718; PIK helical; 1808..2086; PI3K/PI4K catalytic

Region

1814..1820; G-loop; 1954..1962; Catalytic loop; 1973..1997; Activation loop

Protein Families

PI3/PI4-kinase family
Type III PI4K subfamily

Sequence Similarities

Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

Clinical Relevance

Disease Involvement

Disease variantHereditary spastic paraplegiaNeurodegeneration

Drugs

ALPELISIB NULL

Antibody

CAB009092 HPA075515

Interaction Protein

ENSG00000122591ENSG00000165914

Interaction Count

Interaction Dataset

biogrid_opencell