Protein detail
ECE1
Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)
Entry name ECE1 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)
Protein Class (7)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- Disease related genes
Transmembrane
69..89; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ECE
Gene Description
Endothelin converting enzyme 1
Chromosome
1
Position
21217247-21345572
Supporting publications (n)
1
EVMP confidence score
0.53
Fluorescence & Localization
Tissue Specificblood vesselCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain SpecificBergmann glia
Function & Pathway
Protein Function (7)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Potential drug targets
- Enzymes
- ENZYME proteins:Hydrolases
- Peptidases:Metallopeptidases
- Disease related genes
Cellular Component (11)
- GO:0005765 lysosomal membrane
- GO:0005768 endosome
- GO:0005769 early endosome
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0010008 endosome membrane
- GO:0016020 membrane
- GO:0031982 vesicle
- GO:0033093 Weibel-Palade body
- GO:0048471 perinuclear region of cytoplasm
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Molecular Function (6)
Biological Process (3)
Reactome (4)
Mediation Categories (3)
Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence45
Enzyme-Mediated Modification (5)
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ECE1 | CSNK2A1 | P68400 | S | 20 | phosphorylation | PhosphoSite | |
| ECE1 | CSNK2A1 | P68400 | S | 18 | phosphorylation | PhosphoSite | |
| ECE1 | CSNK2A1 | P68400 | T | 9 | phosphorylation | PhosphoSite | |
| ECE1 | CSNK1A1 | P48729 | S | 36 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| ECE1 | CSNK1A1 | P48729 | S | 34 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper |
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | Yes | Yes | |||
| receptor | receptor | OmniPath | Yes | Yes | |||
| extracellular | extracellular | DGIdb | Yes | ||||
| extracellular | extracellular | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | Yes | ||||
| intracellular | intracellular | GO_Intercell | Yes | ||||
| intracellular | intracellular | OmniPath | Yes | ||||
| cell_surface_enzyme | cell_surface_enzyme | Surfaceome | Yes | Yes | |||
| m13_metallopeptidase | cell_surface_peptidase | HGNC | Yes | Yes | |||
| cell_surface_enzyme | cell_surface_enzyme | HGNC | Yes | Yes |
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Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CSK21 | P68400 | ECE1 | P42892 | Yes | PhosphoSite_norefPhosphoSiteiPTMnet | PhosphoSite:32850305PhosphoSite:26543229 | ||
| KC1A | P48729 | ECE1 | P42892 | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:12244060 |
Protein Complex Composition (6)
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ECE1EEF1E1EFHD1GMPPAGMPPB | O43324P42892Q96IJ6Q9BUP0Q9Y5P6 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9835 | ||
| ECE1GAAGGT1GLAREXO2 | P06280P10253P19440P42892Q9Y3B8 | 0:0:0:0:0 | hu.MAP2 | |||
| ECE1GAAME2REXO2 | P10253P23368P42892Q9Y3B8 | 0:0:0:0 | hu.MAP2 | |||
| ECE1GAAREXO2 | P10253P42892Q9Y3B8 | 0:0:0 | hu.MAP2 | |||
| ECE1TPI1 | P42892P60174 | 0:0 | hu.MAP2 | |||
| DNAJC5ECE1FKBP10 | P42892Q96AY3Q9H3Z4 | 0:0:0 | Havugimana2012 | Havugimana2012:C_128 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Flow cytometry | 1 | 27821849 |
Sequence, Structure & Domains
Sequences
Length
770
Mass
87,164
Sequence
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=B; IsoId=P42892-1; Sequence=Displayed; Name=A; IsoId=P42892-2; Sequence=VSP_005502; Name=C; IsoId=P42892-3; Sequence=VSP_005504; Name=D; IsoId=P42892-4; Sequence=VSP_005503
Alternative Sequence
1..44; MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNG -> MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPS (in isoform A); 1..17; MRGVWPPPVSALLSALG -> M (in isoform C); 1..17; MRGVWPPPVSALLSALG -> MEALRESVLHLALQ (in isoform D)
3D Structural Models
Turn
121..123; 270..273; 547..550; 571..574; 585..587; 661..664
Helix
102..114; 125..136; 148..164; 173..186; 189..194; 197..205; 220..229; 266..269; 277..291; 297..317; 321..324; 327..330; 336..342; 348..355; 372..384; 387..402; 403..405; 408..418; 434..455; 458..479; 487..499; 508..511; 513..520; 530..546; 580..582; 594..599; 601..611; 617..619; 632..649; 665..689; 702..713; 720..729; 735..744; 747..753
Beta Strand
144..147; 235..244; 247..256; 261..264; 332..335; 366..370; 501..506; 568..570; 575..579; 653..658; 696..698; 716..718
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
98..770; Peptidase M13
Protein Families
Peptidase M13 family
Sequence Similarities
Belongs to the peptidase M13 family.
Clinical Relevance
Disease Involvement (2)
Disease variantHirschsprung disease
Related Diseases
Interaction Protein
ENSG00000127022
Interaction Count
1
Interaction Dataset
biogrid_opencell
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 37403840 | Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma. | No related sentences available |