Protein detail

ECE1

Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)

Protein symbol ECE1	UniProt ID P42892	EVMP score 0.25
Frequency 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71)

Protein Class

Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Peptidases:Metallopeptidases
Disease related genes

Transmembrane

69..89; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000117298

Entrez Gene Symbol

ECE1

Gene Synonym

ECE

Gene Description

Endothelin converting enzyme 1

Chromosome

Position

21217247-21345572

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificblood vesselCell SpecificDistal convoluted tubule cellsSingle-Nuclei Brain SpecificBergmann glia

Function & Pathway

Protein Function

Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
Potential drug targets
Enzymes
ENZYME proteins:Hydrolases
Peptidases:Metallopeptidases
Disease related genes

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Fusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

5 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
ECE1	CSNK2A1	P68400	S	20	phosphorylation	PhosphoSite
ECE1	CSNK2A1	P68400	S	18	phosphorylation	PhosphoSite
ECE1	CSNK2A1	P68400	T	9	phosphorylation	PhosphoSite
ECE1	CSNK1A1	P48729	S	36	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
ECE1	CSNK1A1	P48729	S	34	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling

31 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
cell_surface_peptidase	cell_surface_peptidase	HGNC	Yes	No	No	Yes	No
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	No	No	Yes	No
cell_surface_peptidase	cell_surface_peptidase	OmniPath	Yes	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

2 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
CSK21	P68400	ECE1	P42892	Yes	No	No	PhosphoSite_norefPhosphoSiteiPTMnet	PhosphoSite:32850305 PhosphoSite:26543229
KC1A	P48729	ECE1	P42892	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:12244060

Protein Complex Composition

6 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ECE1 EEF1E1 EFHD1 GMPPA GMPPB	O43324 P42892 Q96IJ6 Q9BUP0 Q9Y5P6	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9835
ECE1 GAA GGT1 GLA REXO2	P06280 P10253 P19440 P42892 Q9Y3B8	0:0:0:0:0	hu.MAP2
ECE1 GAA ME2 REXO2	P10253 P23368 P42892 Q9Y3B8	0:0:0:0	hu.MAP2
ECE1 GAA REXO2	P10253 P42892 Q9Y3B8	0:0:0	hu.MAP2
ECE1 TPI1	P42892 P60174	0:0	hu.MAP2
DNAJC5 ECE1 FKBP10	P42892 Q96AY3 Q9H3Z4	0:0:0	Havugimana2012	Havugimana2012:C_128

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Flow cytometry	1	27821849

Sequence, Structure & Domains

Sequences

Length

770

Mass

87,164

Sequence

MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=B; IsoId=P42892-1; Sequence=Displayed; Name=A; IsoId=P42892-2; Sequence=VSP_005502; Name=C; IsoId=P42892-3; Sequence=VSP_005504; Name=D; IsoId=P42892-4; Sequence=VSP_005503

Alternative Sequence

1..44; MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNG -> MPLQGLGLQRNPFLQGKRGPGLTSSPPLLPPS (in isoform A); 1..17; MRGVWPPPVSALLSALG -> M (in isoform C); 1..17; MRGVWPPPVSALLSALG -> MEALRESVLHLALQ (in isoform D)

3D Structural Models

Turn

121..123; 270..273; 547..550; 571..574; 585..587; 661..664

Helix

102..114; 125..136; 148..164; 173..186; 189..194; 197..205; 220..229; 266..269; 277..291; 297..317; 321..324; 327..330; 336..342; 348..355; 372..384; 387..402; 403..405; 408..418; 434..455; 458..479; 487..499; 508..511; 513..520; 530..546; 580..582; 594..599; 601..611; 617..619; 632..649; 665..689; 702..713; 720..729; 735..744; 747..753

Beta Strand

144..147; 235..244; 247..256; 261..264; 332..335; 366..370; 501..506; 568..570; 575..579; 653..658; 696..698; 716..718

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Domain (FT)

98..770; Peptidase M13

Protein Families

Peptidase M13 family

Sequence Similarities

Belongs to the peptidase M13 family.

Clinical Relevance

Disease Involvement

Disease variantHirschsprung disease

Drugs

DAGLUTRIL SLV-334 NULL APRIL BAFF BELANTAMAB MAFODOTIN-BLMF

Antibody

HPA001490 HPA013616

Interaction Protein

ENSG00000127022

Interaction Count

Interaction Dataset

biogrid_opencell