Protein detail

PE2R3

Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

Entry name PE2R3	UniProt ID P43115	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

Protein Class (4)

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function (4)

G-protein coupled receptors:GPCRs excl olfactory receptors
Transporters
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

54..78; Helical; Name=1; 92..112; Helical; Name=2; 132..153; Helical; Name=3; 176..197; Helical; Name=4; 228..253; Helical; Name=5; 284..307; Helical; Name=6; 328..349; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000050628

Entrez Gene Symbol

PTGER3

Gene Synonym (2)

EP3lnc003875

Gene Description

Prostaglandin E receptor 3

Chromosome

Position

70852353-71047816

Supporting publications (n)

EVMP confidence score

0.25

Fluorescence & Localization3

Tissue Specificbone marrowCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificastrocyte

Function & Pathway7

Protein Function (4)

G-protein coupled receptors:GPCRs excl olfactory receptors
Transporters
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component (3)

Molecular Function (2)

Biological Process (3)

KEGG (6)

Reactome (6)

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence56

Ligand-Receptor Signaling (45)

45 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
receptor	receptor	scConnect	No	Yes	No	Yes	No
receptor	receptor	CellCall	No	Yes	No	Yes	No

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Regulatory Interaction Network (9)

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PE2R3	P43115	SRC	P12931	Yes	Yes	No	SIGNOR	SIGNOR:15331179
PE2R3	P43115	EGFR	P00533	Yes	Yes	No	SIGNOR	SIGNOR:28415726
PE2R3	P43115	GBB3	P16520	Yes	Yes	No	SIGNOR	SIGNOR:12038972
PE2R3	P43115	GBG12	Q9UBI6	Yes	Yes	No	SIGNOR	SIGNOR:12038972
PE2R3	P43115	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PE2R3	P43115	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	SIGNOR:12038972 HINT:36103815 HINT:37478163 SIGNOR:31160049
PE2R3	P43115	GNAZ	P19086	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PE2R3	P43115	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
PE2R3	P43115	GNA12	Q03113	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTGER3	P43115	0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains11

Sequences

Length

390

Mass

43,310

Sequence

MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER

Alternative Products

Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; Name=EP3-III; IsoId=P43115-8; Sequence=VSP_053774; Name=EP3-IV; IsoId=P43115-9; Sequence=VSP_053775; Name=EP3-V; IsoId=P43115-10; Sequence=VSP_053776; Name=EP3E2; IsoId=P43115-11; Sequence=VSP_053777; Name=12; IsoId=P43115-12; Sequence=VSP_058943

Alternative Sequence

360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQVILLPQPPK (in isoform 12); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAEEFWGN (in isoform EP3-III); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEEFWGN (in isoform EP3-IV); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS (in isoform EP3-V); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EEFWGN (in isoform EP3B); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEA (in isoform EP3C); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQEEFWGN (in isoform EP3D); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE (in isoform EP3E); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQLICSLRTLRYRGQLHIVGKYKPIVC (in isoform EP3E2); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQAPLLPTPTVIDPSRFCAQPFRWFLDLSFPAMSSSHPQLPLTLASFKLLREPCSVQLS (in isoform EP3F); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS (in isoform EP3G)

3D Structural Models

Turn

47..49; 203..206

Helix

53..77; 86..115; 120..123; 128..160; 162..167; 172..189; 191..194; 225..258; 276..306; 324..346; 348..352

Beta Strand

125..127; 199..202; 207..210

3D Structure

Electron microscopy (2); X-ray crystallography (2)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance6

Disease Involvement

FDA approved drug targets

Related Diseases (6)

Asthma Chronic arterial occlusive disease Glaucoma Pain Solid tumour/cancer Transplanted organ/tissue

Biomarker

Discontinued in Phase 1; Discontinued in Phase 2; Phase 2; Investigative; Clinical trial

Drug Targets

FDA approved drug targets

Drugs (10)

DINOPROSTONE DINOPROST ASPIRIN BUTAPROST MISOPROSTOL BIMATOPROST DG041 16,16-DIMETHYL-PGE2 SEPETAPROST NULL

Antibody

HPA010689

Supporting Publications1

PMID	Title	Abstract
32384937	Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles.	No abstract available