Protein detail
PE2R3
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
Entry name PE2R3 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)
Protein Class (4)
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function (4)
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Transmembrane
54..78; Helical; Name=1; 92..112; Helical; Name=2; 132..153; Helical; Name=3; 176..197; Helical; Name=4; 228..253; Helical; Name=5; 284..307; Helical; Name=6; 328..349; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
EP3lnc003875
Gene Description
Prostaglandin E receptor 3
Chromosome
1
Position
70852353-71047816
Supporting publications (n)
1
EVMP confidence score
0.40
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificEndometrial glandular cellsSingle-Nuclei Brain Specificastrocyte
Function & Pathway
Protein Function (4)
- G-protein coupled receptors:GPCRs excl olfactory receptors
- Transporters
- FDA approved drug targets:Small molecule drugs
- FDA approved drug targets:Biotech drugs
Cellular Component (3)
Molecular Function (2)
Biological Process (3)
KEGG (6)
Reactome (6)
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence56
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | Yes | Yes | |||
| gpcr | receptor | GPCRdb | Yes | Yes | |||
| prostaglandin | receptor | HGNC | Yes | Yes | |||
| receptor | receptor | HGNC | Yes | Yes | |||
| transmembrane | transmembrane_predicted | Phobius | Yes |
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Regulatory Interaction Network (9)
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PE2R3 | P43115 | SRC | P12931 | Yes | Yes | SIGNOR | SIGNOR:15331179 | |
| PE2R3 | P43115 | EGFR | P00533 | Yes | Yes | SIGNOR | SIGNOR:28415726 | |
| PE2R3 | P43115 | GBB3 | P16520 | Yes | Yes | SIGNOR | SIGNOR:12038972 | |
| PE2R3 | P43115 | GBG12 | Q9UBI6 | Yes | Yes | SIGNOR | SIGNOR:12038972 | |
| PE2R3 | P43115 | GNAO | P09471 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| PE2R3 | P43115 | GNAI1 | P63096 | Yes | Yes | HINTSIGNOR | SIGNOR:12038972HINT:36103815HINT:37478163SIGNOR:31160049 | |
| PE2R3 | P43115 | GNAZ | P19086 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| PE2R3 | P43115 | GNAI3 | P08754 | Yes | Yes | SIGNOR | SIGNOR:31160049 | |
| PE2R3 | P43115 | GNA12 | Q03113 | Yes | Yes | SIGNOR | SIGNOR:31160049 |
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
390
Mass
43,310
Sequence
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
Alternative Products
Event=Alternative splicing; Named isoforms=12; Comment=Additional isoforms seem to exist.; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; Name=EP3-III; IsoId=P43115-8; Sequence=VSP_053774; Name=EP3-IV; IsoId=P43115-9; Sequence=VSP_053775; Name=EP3-V; IsoId=P43115-10; Sequence=VSP_053776; Name=EP3E2; IsoId=P43115-11; Sequence=VSP_053777; Name=12; IsoId=P43115-12; Sequence=VSP_058943
Alternative Sequence
360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQFWRPASSGSGCQQIRCLMESCSLTQTGVQWSDFRSLQPSPPPLTAIFASWVQVILLPQPPK (in isoform 12); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAEEFWGN (in isoform EP3-III); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEEFWGN (in isoform EP3-IV); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQEMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS (in isoform EP3-V); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EEFWGN (in isoform EP3B); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEA (in isoform EP3C); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQEEFWGN (in isoform EP3D); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQLICSLQNSQIQRATAHCGQVQTYRVLNREEMEVLVSSINVYTRISTVKTE (in isoform EP3E); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> VANAVSSCSNDGQKGQPISLSNEIIQTEAMRKRRLREQLICSLRTLRYRGQLHIVGKYKPIVC (in isoform EP3E2); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> MRKRRLREQAPLLPTPTVIDPSRFCAQPFRWFLDLSFPAMSSSHPQLPLTLASFKLLREPCSVQLS (in isoform EP3F); 360..390; IRYHTNNYASSSTSLPCQCSSTLMWSDHLER -> EMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS (in isoform EP3G)
3D Structural Models
Turn
47..49; 203..206
Helix
53..77; 86..115; 120..123; 128..160; 162..167; 172..189; 191..194; 225..258; 276..306; 324..346; 348..352
Beta Strand
125..127; 199..202; 207..210
3D Structure
Electron microscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases (6)
Biomarker
Discontinued in Phase 1; Discontinued in Phase 2; Phase 2; Investigative; Clinical trial
Drug Targets
FDA approved drug targets
Drugs (10)
Antibody
Supporting Publications1
| PMID | Title | Related sentences |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No related sentences available |